Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer
BackgroundDespite advancements in cancer treatment, understanding the long-term mental health implications for nasopharyngeal carcinoma (NPC) survivors remains an underexplored area. This study aims to examine the prevalence of mental disorders and their correlations with age at diagnosis and time s...
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Frontiers Media S.A.
2024-12-01
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| author | Wen-Xuan Wang Wen-Xuan Wang Yi-Shan Wu Yi-Shan Wu Li-Ping Qi Li-Ping Qi Anise M. S. Wu Anise M. S. Wu Ying-Ying Zhu Wei-Jie Gong Shan-Shan Guo Shan-Shan Guo Yi-Jun Hua Yi-Jun Hua Dong-Hua Luo Dong-Hua Luo Qiu-Yan Chen Qiu-Yan Chen Yan-Qun Xiang Yan-Qun Xiang Jin-Xin Zhang Hai-Qiang Mai Hai-Qiang Mai Ji-Bin Li Ji-Bin Li |
| author_facet | Wen-Xuan Wang Wen-Xuan Wang Yi-Shan Wu Yi-Shan Wu Li-Ping Qi Li-Ping Qi Anise M. S. Wu Anise M. S. Wu Ying-Ying Zhu Wei-Jie Gong Shan-Shan Guo Shan-Shan Guo Yi-Jun Hua Yi-Jun Hua Dong-Hua Luo Dong-Hua Luo Qiu-Yan Chen Qiu-Yan Chen Yan-Qun Xiang Yan-Qun Xiang Jin-Xin Zhang Hai-Qiang Mai Hai-Qiang Mai Ji-Bin Li Ji-Bin Li |
| author_sort | Wen-Xuan Wang |
| collection | DOAJ |
| description | BackgroundDespite advancements in cancer treatment, understanding the long-term mental health implications for nasopharyngeal carcinoma (NPC) survivors remains an underexplored area. This study aims to examine the prevalence of mental disorders and their correlations with age at diagnosis and time since diagnosis among NPC survivors.MethodsA total of 1872 NPC patients were surveyed from September 2020 to June 2021 in this cross-sectional survey. Logistic regression models were used to analyze the associations of age at diagnosis and time since NPC diagnosis with the risk of mental disorders. Additionally, the potential nonlinear trend between these factors was examined using restricted cubic splines. Analyses were conducted both overall and stratified by gender. Gender interaction was also examined.ResultsThe prevalences of depression, anxiety, and sleep disorders were 32.4, 33.2, and 61.5%, respectively. Age at NPC diagnosis was significantly associated with an elevated risk of depression (adjusted OR (aOR): 1.75 for 30–39 years old; 2.33 for 50–59 years old; 2.59 for ≥60 years old) and sleep disorders (aOR: 2.41 for 40–49 years old; 1.95 for 50–59 years old; 2.26, for ≥60 years old), compared to patients diagnosed with NPC at age < 30 years. Conversely, the risk of depression, anxiety, and sleep disorders exhibited negative associations with the time since diagnosis, compared to patients <3 months. Notably, significant nonlinear associations were observed between time since diagnosis and the risk of depression, anxiety, and sleep disorders, which showed an initial increase, with the highest risk occurring at approximately 3.0 (ORmax: 2.7), 1.5 (ORmax: 2.1), and 4.0 (ORmax: 1.9) months since NPC diagnosis, followed by a gradual recovery to a lower risk level at around 12 months. No gender interactions were observed.ConclusionThe prevalence of mental disorders is notable among NPC survivors, showing a positive correlation with age at diagnosis while displaying a negative correlation with time since diagnosis, thus indicating the need for psychological support, especially within the initial several months following NPC diagnosis. |
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| spelling | doaj-art-4d2e8df68be346ffa76efcdaf1d8b7142025-08-20T02:38:30ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-12-011210.3389/fpubh.2024.14690011469001Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancerWen-Xuan Wang0Wen-Xuan Wang1Yi-Shan Wu2Yi-Shan Wu3Li-Ping Qi4Li-Ping Qi5Anise M. S. Wu6Anise M. S. Wu7Ying-Ying Zhu8Wei-Jie Gong9Shan-Shan Guo10Shan-Shan Guo11Yi-Jun Hua12Yi-Jun Hua13Dong-Hua Luo14Dong-Hua Luo15Qiu-Yan Chen16Qiu-Yan Chen17Yan-Qun Xiang18Yan-Qun Xiang19Jin-Xin Zhang20Hai-Qiang Mai21Hai-Qiang Mai22Ji-Bin Li23Ji-Bin Li24School of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Clinical Research, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Psychology, Faculty of Social Sciences, University of Macau, Taipa, Macao SAR, ChinaCentre for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Taipa, Macao SAR, ChinaClinical Research Design Division, Clinical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Family Medicine, Shenzhen University Medical School, Shenzhen University, Shenzhen, ChinaDepartment of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Clinical Research, Sun Yat-sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, ChinaBackgroundDespite advancements in cancer treatment, understanding the long-term mental health implications for nasopharyngeal carcinoma (NPC) survivors remains an underexplored area. This study aims to examine the prevalence of mental disorders and their correlations with age at diagnosis and time since diagnosis among NPC survivors.MethodsA total of 1872 NPC patients were surveyed from September 2020 to June 2021 in this cross-sectional survey. Logistic regression models were used to analyze the associations of age at diagnosis and time since NPC diagnosis with the risk of mental disorders. Additionally, the potential nonlinear trend between these factors was examined using restricted cubic splines. Analyses were conducted both overall and stratified by gender. Gender interaction was also examined.ResultsThe prevalences of depression, anxiety, and sleep disorders were 32.4, 33.2, and 61.5%, respectively. Age at NPC diagnosis was significantly associated with an elevated risk of depression (adjusted OR (aOR): 1.75 for 30–39 years old; 2.33 for 50–59 years old; 2.59 for ≥60 years old) and sleep disorders (aOR: 2.41 for 40–49 years old; 1.95 for 50–59 years old; 2.26, for ≥60 years old), compared to patients diagnosed with NPC at age < 30 years. Conversely, the risk of depression, anxiety, and sleep disorders exhibited negative associations with the time since diagnosis, compared to patients <3 months. Notably, significant nonlinear associations were observed between time since diagnosis and the risk of depression, anxiety, and sleep disorders, which showed an initial increase, with the highest risk occurring at approximately 3.0 (ORmax: 2.7), 1.5 (ORmax: 2.1), and 4.0 (ORmax: 1.9) months since NPC diagnosis, followed by a gradual recovery to a lower risk level at around 12 months. No gender interactions were observed.ConclusionThe prevalence of mental disorders is notable among NPC survivors, showing a positive correlation with age at diagnosis while displaying a negative correlation with time since diagnosis, thus indicating the need for psychological support, especially within the initial several months following NPC diagnosis.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1469001/fullnasopharyngeal carcinomadepressionanxietysleep disordersage at diagnosistime since diagnosis |
| spellingShingle | Wen-Xuan Wang Wen-Xuan Wang Yi-Shan Wu Yi-Shan Wu Li-Ping Qi Li-Ping Qi Anise M. S. Wu Anise M. S. Wu Ying-Ying Zhu Wei-Jie Gong Shan-Shan Guo Shan-Shan Guo Yi-Jun Hua Yi-Jun Hua Dong-Hua Luo Dong-Hua Luo Qiu-Yan Chen Qiu-Yan Chen Yan-Qun Xiang Yan-Qun Xiang Jin-Xin Zhang Hai-Qiang Mai Hai-Qiang Mai Ji-Bin Li Ji-Bin Li Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer Frontiers in Public Health nasopharyngeal carcinoma depression anxiety sleep disorders age at diagnosis time since diagnosis |
| title | Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer |
| title_full | Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer |
| title_fullStr | Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer |
| title_full_unstemmed | Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer |
| title_short | Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer |
| title_sort | prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer |
| topic | nasopharyngeal carcinoma depression anxiety sleep disorders age at diagnosis time since diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1469001/full |
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