A case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for recurrent malignant melanoma of the esophagus
Abstract Background The treatment strategy for metastatic lesions of primary malignant melanoma of the esophagus (PMME) is currently determined on a case-by-case basis, based on the National Comprehensive Cancer Network (NCCN) guidelines for cutaneous melanoma. The NCCN guidelines state that resecti...
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Japan Surgical Society
2022-11-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-022-01561-z |
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| author | Keita Hanada Shigeru Tsunoda Motoo Nomura Shintaro Fujimura Yojiro Yutaka Tatsuto Nishigori Shigeo Hisamori Hisatsugu Maekewa Nobuaki Hoshino Atsushi Itami Eiji Tanaka Kazutaka Obama |
| author_facet | Keita Hanada Shigeru Tsunoda Motoo Nomura Shintaro Fujimura Yojiro Yutaka Tatsuto Nishigori Shigeo Hisamori Hisatsugu Maekewa Nobuaki Hoshino Atsushi Itami Eiji Tanaka Kazutaka Obama |
| author_sort | Keita Hanada |
| collection | DOAJ |
| description | Abstract Background The treatment strategy for metastatic lesions of primary malignant melanoma of the esophagus (PMME) is currently determined on a case-by-case basis, based on the National Comprehensive Cancer Network (NCCN) guidelines for cutaneous melanoma. The NCCN guidelines state that resection should be considered in patients with resectable metastatic recurrence. Herein, we report a case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for the metastatic recurrence of PMME. Case presentation A 65-year-old female patient with PMME underwent thoracoscopic subtotal esophagectomy, gastric tube reconstruction via the posterior mediastinal route, and cervical esophagogastric anastomosis. Histopathological examination of the resected specimen revealed that the tumor was PMME with tumor invasion into the muscularis propria and no lymph node metastasis. At the age of 68 years, she developed intestinal invagination due to jejunal metastasis of malignant melanoma and underwent resection of the jejunum. Histopathological examination of the resected specimen revealed two metastases of malignant melanoma in the jejunum and one metastasis to the mesenteric lymph node. At the age of 75 years, a recurrence of malignant melanoma was found in the cervical esophagus. She underwent thoracoscopic mobilization of the gastric tube and esophagus followed by cervical esophagectomy and reconstruction with a free jejunum flap. She received 24 courses of nivolumab therapy for 1 year as a postoperative adjuvant therapy. Subsequently, at the age of 78 years, an enlarged left cervical lymph node and a mass in the right lower lobe of the lung were found. She underwent left cervical lymph node dissection and thoracoscopic wedge resection of the right lung. Histopathological examination of the resected specimens revealed that both tumors were metastases of malignant melanoma. At age 79 years, she received eight courses of nivolumab therapy as a second postoperative adjuvant therapy, with no sign of recurrence in a 9-month follow-up period after the third metastasectomy. Conclusion In cases of metastatic recurrence of PMME, aggressive resection of oligometastasis with postoperative adjuvant nivolumab therapy may result in long-term survival. |
| format | Article |
| id | doaj-art-4d2d665c52fd45bfa0069314a2004a13 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-4d2d665c52fd45bfa0069314a2004a132025-08-20T03:33:20ZengJapan Surgical SocietySurgical Case Reports2198-77932022-11-01811610.1186/s40792-022-01561-zA case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for recurrent malignant melanoma of the esophagusKeita Hanada0Shigeru Tsunoda1Motoo Nomura2Shintaro Fujimura3Yojiro Yutaka4Tatsuto Nishigori5Shigeo Hisamori6Hisatsugu Maekewa7Nobuaki Hoshino8Atsushi Itami9Eiji Tanaka10Kazutaka Obama11Department of Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Clinical Oncology, Kyoto University HospitalDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Thoracic Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Surgery, Graduate School of Medicine, Kyoto UniversityAbstract Background The treatment strategy for metastatic lesions of primary malignant melanoma of the esophagus (PMME) is currently determined on a case-by-case basis, based on the National Comprehensive Cancer Network (NCCN) guidelines for cutaneous melanoma. The NCCN guidelines state that resection should be considered in patients with resectable metastatic recurrence. Herein, we report a case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for the metastatic recurrence of PMME. Case presentation A 65-year-old female patient with PMME underwent thoracoscopic subtotal esophagectomy, gastric tube reconstruction via the posterior mediastinal route, and cervical esophagogastric anastomosis. Histopathological examination of the resected specimen revealed that the tumor was PMME with tumor invasion into the muscularis propria and no lymph node metastasis. At the age of 68 years, she developed intestinal invagination due to jejunal metastasis of malignant melanoma and underwent resection of the jejunum. Histopathological examination of the resected specimen revealed two metastases of malignant melanoma in the jejunum and one metastasis to the mesenteric lymph node. At the age of 75 years, a recurrence of malignant melanoma was found in the cervical esophagus. She underwent thoracoscopic mobilization of the gastric tube and esophagus followed by cervical esophagectomy and reconstruction with a free jejunum flap. She received 24 courses of nivolumab therapy for 1 year as a postoperative adjuvant therapy. Subsequently, at the age of 78 years, an enlarged left cervical lymph node and a mass in the right lower lobe of the lung were found. She underwent left cervical lymph node dissection and thoracoscopic wedge resection of the right lung. Histopathological examination of the resected specimens revealed that both tumors were metastases of malignant melanoma. At age 79 years, she received eight courses of nivolumab therapy as a second postoperative adjuvant therapy, with no sign of recurrence in a 9-month follow-up period after the third metastasectomy. Conclusion In cases of metastatic recurrence of PMME, aggressive resection of oligometastasis with postoperative adjuvant nivolumab therapy may result in long-term survival.https://doi.org/10.1186/s40792-022-01561-zPrimary malignant melanoma of the esophagusMetastasisRecurrenceNivolumab |
| spellingShingle | Keita Hanada Shigeru Tsunoda Motoo Nomura Shintaro Fujimura Yojiro Yutaka Tatsuto Nishigori Shigeo Hisamori Hisatsugu Maekewa Nobuaki Hoshino Atsushi Itami Eiji Tanaka Kazutaka Obama A case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for recurrent malignant melanoma of the esophagus Surgical Case Reports Primary malignant melanoma of the esophagus Metastasis Recurrence Nivolumab |
| title | A case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for recurrent malignant melanoma of the esophagus |
| title_full | A case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for recurrent malignant melanoma of the esophagus |
| title_fullStr | A case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for recurrent malignant melanoma of the esophagus |
| title_full_unstemmed | A case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for recurrent malignant melanoma of the esophagus |
| title_short | A case of long-term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for recurrent malignant melanoma of the esophagus |
| title_sort | case of long term survival treated with three metastasectomies and two subsequent adjuvant nivolumab therapies for recurrent malignant melanoma of the esophagus |
| topic | Primary malignant melanoma of the esophagus Metastasis Recurrence Nivolumab |
| url | https://doi.org/10.1186/s40792-022-01561-z |
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