Single-Lung Transplant Results in Position Dependent Changes in Regional Ventilation: An Observational Case Series Using Electrical Impedance Tomography
Background. Lung transplantation is the optimal treatment for end stage lung disease. Donor shortage necessitates single-lung transplants (SLT), yet minimal data exists regarding regional ventilation in diseased versus transplanted lung measured by Electrical Impedance Tomography (EIT). Method. We a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/2471207 |
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| author | Kollengode Ramanathan Hend Mohammed Peter Hopkins Amanda Corley Lawrence Caruana Kimble Dunster Adrian G. Barnett John F. Fraser |
| author_facet | Kollengode Ramanathan Hend Mohammed Peter Hopkins Amanda Corley Lawrence Caruana Kimble Dunster Adrian G. Barnett John F. Fraser |
| author_sort | Kollengode Ramanathan |
| collection | DOAJ |
| description | Background. Lung transplantation is the optimal treatment for end stage lung disease. Donor shortage necessitates single-lung transplants (SLT), yet minimal data exists regarding regional ventilation in diseased versus transplanted lung measured by Electrical Impedance Tomography (EIT). Method. We aimed to determine regional ventilation in six SLT outpatients using EIT. We assessed end expiratory volume and tidal volumes. End expiratory lung impedance (EELI) and Global Tidal Variation of Impedance were assessed in supine, right lateral, left lateral, sitting, and standing positions in transplanted and diseased lungs. A mixed model with random intercept per subject was used for statistical analysis. Results. EELI was significantly altered between diseased and transplanted lungs whilst lying on right and left side. One patient demonstrated pendelluft between lungs and was therefore excluded for further comparison of tidal variation. Tidal variation was significantly higher in the transplanted lung for the remaining five patients in all positions, except when lying on the right side. Conclusion. Ventilation to transplanted lung is better than diseased lung, especially in lateral positions. Positioning in patients with active unilateral lung pathologies will be implicated. This is the first study demonstrating changes in regional ventilation, associated with changes of position between transplanted and diseased lung. |
| format | Article |
| id | doaj-art-4d2c97d7885847a6bf183d5f6e465fbb |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-4d2c97d7885847a6bf183d5f6e465fbb2025-02-03T05:45:48ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/24712072471207Single-Lung Transplant Results in Position Dependent Changes in Regional Ventilation: An Observational Case Series Using Electrical Impedance TomographyKollengode Ramanathan0Hend Mohammed1Peter Hopkins2Amanda Corley3Lawrence Caruana4Kimble Dunster5Adrian G. Barnett6John F. Fraser7The Critical Care Research Group, The Prince Charles Hospital and the University of Queensland, Brisbane, QLD 4032, AustraliaThe Critical Care Research Group, The Prince Charles Hospital and the University of Queensland, Brisbane, QLD 4032, AustraliaThe Critical Care Research Group, The Prince Charles Hospital and the University of Queensland, Brisbane, QLD 4032, AustraliaThe Critical Care Research Group, The Prince Charles Hospital and the University of Queensland, Brisbane, QLD 4032, AustraliaThe Critical Care Research Group, The Prince Charles Hospital and the University of Queensland, Brisbane, QLD 4032, AustraliaThe Critical Care Research Group, The Prince Charles Hospital and the University of Queensland, Brisbane, QLD 4032, AustraliaInstitute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4059, AustraliaThe Critical Care Research Group, The Prince Charles Hospital and the University of Queensland, Brisbane, QLD 4032, AustraliaBackground. Lung transplantation is the optimal treatment for end stage lung disease. Donor shortage necessitates single-lung transplants (SLT), yet minimal data exists regarding regional ventilation in diseased versus transplanted lung measured by Electrical Impedance Tomography (EIT). Method. We aimed to determine regional ventilation in six SLT outpatients using EIT. We assessed end expiratory volume and tidal volumes. End expiratory lung impedance (EELI) and Global Tidal Variation of Impedance were assessed in supine, right lateral, left lateral, sitting, and standing positions in transplanted and diseased lungs. A mixed model with random intercept per subject was used for statistical analysis. Results. EELI was significantly altered between diseased and transplanted lungs whilst lying on right and left side. One patient demonstrated pendelluft between lungs and was therefore excluded for further comparison of tidal variation. Tidal variation was significantly higher in the transplanted lung for the remaining five patients in all positions, except when lying on the right side. Conclusion. Ventilation to transplanted lung is better than diseased lung, especially in lateral positions. Positioning in patients with active unilateral lung pathologies will be implicated. This is the first study demonstrating changes in regional ventilation, associated with changes of position between transplanted and diseased lung.http://dx.doi.org/10.1155/2016/2471207 |
| spellingShingle | Kollengode Ramanathan Hend Mohammed Peter Hopkins Amanda Corley Lawrence Caruana Kimble Dunster Adrian G. Barnett John F. Fraser Single-Lung Transplant Results in Position Dependent Changes in Regional Ventilation: An Observational Case Series Using Electrical Impedance Tomography Canadian Respiratory Journal |
| title | Single-Lung Transplant Results in Position Dependent Changes in Regional Ventilation: An Observational Case Series Using Electrical Impedance Tomography |
| title_full | Single-Lung Transplant Results in Position Dependent Changes in Regional Ventilation: An Observational Case Series Using Electrical Impedance Tomography |
| title_fullStr | Single-Lung Transplant Results in Position Dependent Changes in Regional Ventilation: An Observational Case Series Using Electrical Impedance Tomography |
| title_full_unstemmed | Single-Lung Transplant Results in Position Dependent Changes in Regional Ventilation: An Observational Case Series Using Electrical Impedance Tomography |
| title_short | Single-Lung Transplant Results in Position Dependent Changes in Regional Ventilation: An Observational Case Series Using Electrical Impedance Tomography |
| title_sort | single lung transplant results in position dependent changes in regional ventilation an observational case series using electrical impedance tomography |
| url | http://dx.doi.org/10.1155/2016/2471207 |
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