T2 cytokine-driven alarmin and antiviral responses in asthma: insights into immune modulation and the role of IL-4Rα targeting

T2 cytokine-driven alarmin and antiviral responses in asthma: insights into immune modulation and the role of IL-4Rα targeting

IntroductionSevere asthma is a heterogeneous condition characterized by distinct phenotypes and endotypes based on clinical or biological characteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2 (T2) immune response, crucial for T2 inflammation. Biologic therapies targeting...

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Bibliographic Details
Main Authors: Jelena Pesic, Juan José Nieto-Fontarigo, Katerina Pardali, Stephen Delaney, Henric Olsson, Lena Uller
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Allergy
Subjects:
asthma
bronchial epithelial cells
IL-4
IL-13
IL-4Rα mAb
CCL26
Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2025.1576816/full
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