Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages
ABSTRACT: Both tea polyphenols and selenium (Se) have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation, which make Se-enriched oolong tea a promising beverage as an anti-inflammatory diet. The aim of this study is to investigate the anti-inflammatory...
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Tsinghua University Press
2022-05-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021001488 |
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| author | Qi Wang Juqing Huang Yafeng Zheng Xuefang Guan Chenchun Lai Huiying Gao Chi-Tang Ho Bin Lin |
| author_facet | Qi Wang Juqing Huang Yafeng Zheng Xuefang Guan Chenchun Lai Huiying Gao Chi-Tang Ho Bin Lin |
| author_sort | Qi Wang |
| collection | DOAJ |
| description | ABSTRACT: Both tea polyphenols and selenium (Se) have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation, which make Se-enriched oolong tea a promising beverage as an anti-inflammatory diet. The aim of this study is to investigate the anti-inflammatory effects of Se-enriched oolong tea extract (Se-TE) and underlying mechanism in lipopolysaccharide (LPS)-induced RAW264.7 cells. Se-TE treatments (50 and 150 μg/mL) significantly suppressed the over-production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, Se-TEs also effectively inhibited the productions of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). Furthermore, Se-TE could block mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways through the inhibition of the phosphorylation of key proteins (IκB-α, p65, p38, ERK, and JNK) and the translocation of the p65 subunit into the nucleus. Collectively, our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases. |
| format | Article |
| id | doaj-art-4d287b6d67fb4c5bb4f22c42d53cafab |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-4d287b6d67fb4c5bb4f22c42d53cafab2025-02-03T05:14:30ZengTsinghua University PressFood Science and Human Wellness2213-45302022-05-01113635642Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophagesQi Wang0Juqing Huang1Yafeng Zheng2Xuefang Guan3Chenchun Lai4Huiying Gao5Chi-Tang Ho6Bin Lin7Institute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, ChinaInstitute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaInstitute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, ChinaInstitute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, ChinaInstitute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, ChinaDepartment of Food Science, Rutgers University, New Brunswick, NJ 08901, USAInstitute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, China; Corresponding author at: Institute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China.ABSTRACT: Both tea polyphenols and selenium (Se) have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation, which make Se-enriched oolong tea a promising beverage as an anti-inflammatory diet. The aim of this study is to investigate the anti-inflammatory effects of Se-enriched oolong tea extract (Se-TE) and underlying mechanism in lipopolysaccharide (LPS)-induced RAW264.7 cells. Se-TE treatments (50 and 150 μg/mL) significantly suppressed the over-production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, Se-TEs also effectively inhibited the productions of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). Furthermore, Se-TE could block mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways through the inhibition of the phosphorylation of key proteins (IκB-α, p65, p38, ERK, and JNK) and the translocation of the p65 subunit into the nucleus. Collectively, our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases.http://www.sciencedirect.com/science/article/pii/S2213453021001488Oolong teaSeleniumAnti-inflammatoryNF-κB and MAPK pathways |
| spellingShingle | Qi Wang Juqing Huang Yafeng Zheng Xuefang Guan Chenchun Lai Huiying Gao Chi-Tang Ho Bin Lin Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages Food Science and Human Wellness Oolong tea Selenium Anti-inflammatory NF-κB and MAPK pathways |
| title | Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages |
| title_full | Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages |
| title_fullStr | Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages |
| title_full_unstemmed | Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages |
| title_short | Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages |
| title_sort | selenium enriched oolong tea camellia sinensis extract exerts anti inflammatory potential via targeting nf κb and mapk pathways in macrophages |
| topic | Oolong tea Selenium Anti-inflammatory NF-κB and MAPK pathways |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021001488 |
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