Epidemiologic profile of hemoglobinopathies in Benin
Background: Sickle cell disease is the most common inherited blood disorder in the world with the birth of approximately 300,000 newborns screened each year. In 2009, the World Health Organization ranked the fight against sickle cell disease among the priorities for the Africa regions. The best way...
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Elsevier
2024-12-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137924028153 |
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| author | Selma Gomez Adjile Edjide Roukiyath Amoussa Edwige Dedjinou Manasse Kakpo Pélagie Gbédji Nouhoum Amossou Soulé Bernice Quenum |
| author_facet | Selma Gomez Adjile Edjide Roukiyath Amoussa Edwige Dedjinou Manasse Kakpo Pélagie Gbédji Nouhoum Amossou Soulé Bernice Quenum |
| author_sort | Selma Gomez |
| collection | DOAJ |
| description | Background: Sickle cell disease is the most common inherited blood disorder in the world with the birth of approximately 300,000 newborns screened each year. In 2009, the World Health Organization ranked the fight against sickle cell disease among the priorities for the Africa regions. The best way to prevent this incurable disease remains, on one hand systematic screening at birth, and on the other the proscription of risky union between heterozygous subjects. Aim: The aim of this study was to analyze the epidemiological profile of sickle cell disease and other hemoglobinopathies in Benin and determine more up-to-date prevalence rates of the disease within the population. Methods: The hemoglobin profiles of 2910 study participants were determined by quantitative electrophoresis. Samples with abnormal hemoglobin results were subjected to a complete blood count. Results: Our study population was balanced between males (1528) and females (1382) with a sex ratio of 1.1. The mean age ranged from eight years in the pediatric group to 26 years in adults. The hemoglobin electrophoresis profiles found were as follows: 59.7 % Hb AA (normal), 21.7 % Hb AS, 10.2 % Hb AC, 3.1 % Hb SS, 3.7 % Hb SC, and 1.6 % of the rare phenotypes (Hb AD, Hb AE, Hb AF, Hb A/β-thal, Hb SD, Hb SF, Hb CC and Hb C/β-thal). Participants with abnormal hemoglobin presented a normochromic normocytic anemia. A total of 356 (12 %) people knew their profile compared to 2554 (88 %) who did not. Conclusion: The high prevalence of hemoglobinopathies found in this study highlights in importance of screening in the Benin population. |
| format | Article |
| id | doaj-art-4d24eeb019454d62bc35ab45d8abea24 |
| institution | OA Journals |
| issn | 2531-1379 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-4d24eeb019454d62bc35ab45d8abea242025-08-20T01:57:00ZengElsevierHematology, Transfusion and Cell Therapy2531-13792024-12-0146S257S26210.1016/j.htct.2024.07.008Epidemiologic profile of hemoglobinopathies in BeninSelma Gomez0Adjile Edjide Roukiyath Amoussa1Edwige Dedjinou2Manasse Kakpo3Pélagie Gbédji4Nouhoum Amossou Soulé5Bernice Quenum6Centre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose (CPMI-NFED), Benin; Laboratory of Biology and Molecular Typing in Microbiology, University of Abomey-Calavi, Benin; Corresponding author at: Centre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose (CPMI-NFED), Cotonou, Benin.Centre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose (CPMI-NFED), Benin; Laboratory of Cell Biology, Physiology and Immunology, Faculty of Sciences and Technology, University of Abomey-Calavi, BeninCentre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose (CPMI-NFED), BeninCentre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose (CPMI-NFED), BeninCentre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose (CPMI-NFED), BeninCentre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose (CPMI-NFED), BeninCentre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose (CPMI-NFED), BeninBackground: Sickle cell disease is the most common inherited blood disorder in the world with the birth of approximately 300,000 newborns screened each year. In 2009, the World Health Organization ranked the fight against sickle cell disease among the priorities for the Africa regions. The best way to prevent this incurable disease remains, on one hand systematic screening at birth, and on the other the proscription of risky union between heterozygous subjects. Aim: The aim of this study was to analyze the epidemiological profile of sickle cell disease and other hemoglobinopathies in Benin and determine more up-to-date prevalence rates of the disease within the population. Methods: The hemoglobin profiles of 2910 study participants were determined by quantitative electrophoresis. Samples with abnormal hemoglobin results were subjected to a complete blood count. Results: Our study population was balanced between males (1528) and females (1382) with a sex ratio of 1.1. The mean age ranged from eight years in the pediatric group to 26 years in adults. The hemoglobin electrophoresis profiles found were as follows: 59.7 % Hb AA (normal), 21.7 % Hb AS, 10.2 % Hb AC, 3.1 % Hb SS, 3.7 % Hb SC, and 1.6 % of the rare phenotypes (Hb AD, Hb AE, Hb AF, Hb A/β-thal, Hb SD, Hb SF, Hb CC and Hb C/β-thal). Participants with abnormal hemoglobin presented a normochromic normocytic anemia. A total of 356 (12 %) people knew their profile compared to 2554 (88 %) who did not. Conclusion: The high prevalence of hemoglobinopathies found in this study highlights in importance of screening in the Benin population.http://www.sciencedirect.com/science/article/pii/S2531137924028153Sickle cell diseaseScreeningPreventionMortalityMorbidity |
| spellingShingle | Selma Gomez Adjile Edjide Roukiyath Amoussa Edwige Dedjinou Manasse Kakpo Pélagie Gbédji Nouhoum Amossou Soulé Bernice Quenum Epidemiologic profile of hemoglobinopathies in Benin Hematology, Transfusion and Cell Therapy Sickle cell disease Screening Prevention Mortality Morbidity |
| title | Epidemiologic profile of hemoglobinopathies in Benin |
| title_full | Epidemiologic profile of hemoglobinopathies in Benin |
| title_fullStr | Epidemiologic profile of hemoglobinopathies in Benin |
| title_full_unstemmed | Epidemiologic profile of hemoglobinopathies in Benin |
| title_short | Epidemiologic profile of hemoglobinopathies in Benin |
| title_sort | epidemiologic profile of hemoglobinopathies in benin |
| topic | Sickle cell disease Screening Prevention Mortality Morbidity |
| url | http://www.sciencedirect.com/science/article/pii/S2531137924028153 |
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