Microneedles with Interdigitated Electrodes for In Situ Impedimetric VEGF Sensing
Abstract Continuous monitoring of protein biomarkers in interstitial fluid (ISF) is essential for improving patient care and outcomes. This study presents a novel electrochemical impedance spectroscopy (EIS) sensor utilizing microneedles (MNs) patterned with interdigitated electrodes for the detecti...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-05-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202400789 |
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| author | Ritu Das Emin Istif Rumeysa Cebecioglu Mohsin Ali Yasin Atik Çağdaş Dağ Eda Celikbas Gozde Demirci FundaYagcı Acar Murat Hasanreisoğlu Levent Beker |
| author_facet | Ritu Das Emin Istif Rumeysa Cebecioglu Mohsin Ali Yasin Atik Çağdaş Dağ Eda Celikbas Gozde Demirci FundaYagcı Acar Murat Hasanreisoğlu Levent Beker |
| author_sort | Ritu Das |
| collection | DOAJ |
| description | Abstract Continuous monitoring of protein biomarkers in interstitial fluid (ISF) is essential for improving patient care and outcomes. This study presents a novel electrochemical impedance spectroscopy (EIS) sensor utilizing microneedles (MNs) patterned with interdigitated electrodes for the detection of vascular endothelial growth factor (VEGF). The MNs, are fabricated from flexible polylactide (PLA) using a simple molding technique, followed by metal deposition with an interdigitated pattern to serve as a platform for the EIS sensor. After functionalization with anti‐VEGF antibodies, impedance measurements are conducted to detect VEGF levels, demonstrating a significant change in impedance in response to varying concentrations of the target biomarker. The MNs can easily penetrate rat skin by hand, puncturing without mechanical breakage. This innovative approach enhances the sensitivity and specificity of biomarker detection and paves the way for continuous monitoring applications in diagnostics and preventative medicine. |
| format | Article |
| id | doaj-art-4d1fdfe43f414e10890e9edeb4849565 |
| institution | DOAJ |
| issn | 2196-7350 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj-art-4d1fdfe43f414e10890e9edeb48495652025-08-20T03:11:06ZengWiley-VCHAdvanced Materials Interfaces2196-73502025-05-01129n/an/a10.1002/admi.202400789Microneedles with Interdigitated Electrodes for In Situ Impedimetric VEGF SensingRitu Das0Emin Istif1Rumeysa Cebecioglu2Mohsin Ali3Yasin Atik4Çağdaş Dağ5Eda Celikbas6Gozde Demirci7FundaYagcı Acar8Murat Hasanreisoğlu9Levent Beker10Department of Mechanical Engineering Koç University Istanbul 34450 TurkeyDepartment of Mechanical Engineering Koç University Istanbul 34450 TurkeyDepartment of Biomedical Sciences and Engineering Koç University Istanbul 34450 TurkeyDepartment of Biomedical Sciences and Engineering Koç University Istanbul 34450 TurkeyDepartment of Mechanical Engineering Koç University Istanbul 34450 TurkeyNanofabrication and Nanocharacterization Centre for Scientific and Technological Advanced Research Koç University Istanbul 34450 TurkeyDepartment of Chemistry Koç University Istanbul 34450 TurkeyDepartment of Chemistry Koç University Istanbul 34450 TurkeyDepartment of Chemistry Koç University Istanbul 34450 TurkeyDepartment of Opthalmology School of Medicine Koç University Hospital Topkapı caddesi Zeytinburnu Istanbul 34010 TurkeyDepartment of Mechanical Engineering Koç University Istanbul 34450 TurkeyAbstract Continuous monitoring of protein biomarkers in interstitial fluid (ISF) is essential for improving patient care and outcomes. This study presents a novel electrochemical impedance spectroscopy (EIS) sensor utilizing microneedles (MNs) patterned with interdigitated electrodes for the detection of vascular endothelial growth factor (VEGF). The MNs, are fabricated from flexible polylactide (PLA) using a simple molding technique, followed by metal deposition with an interdigitated pattern to serve as a platform for the EIS sensor. After functionalization with anti‐VEGF antibodies, impedance measurements are conducted to detect VEGF levels, demonstrating a significant change in impedance in response to varying concentrations of the target biomarker. The MNs can easily penetrate rat skin by hand, puncturing without mechanical breakage. This innovative approach enhances the sensitivity and specificity of biomarker detection and paves the way for continuous monitoring applications in diagnostics and preventative medicine.https://doi.org/10.1002/admi.202400789biosensorcapacitivemicroneedleVEGF |
| spellingShingle | Ritu Das Emin Istif Rumeysa Cebecioglu Mohsin Ali Yasin Atik Çağdaş Dağ Eda Celikbas Gozde Demirci FundaYagcı Acar Murat Hasanreisoğlu Levent Beker Microneedles with Interdigitated Electrodes for In Situ Impedimetric VEGF Sensing Advanced Materials Interfaces biosensor capacitive microneedle VEGF |
| title | Microneedles with Interdigitated Electrodes for In Situ Impedimetric VEGF Sensing |
| title_full | Microneedles with Interdigitated Electrodes for In Situ Impedimetric VEGF Sensing |
| title_fullStr | Microneedles with Interdigitated Electrodes for In Situ Impedimetric VEGF Sensing |
| title_full_unstemmed | Microneedles with Interdigitated Electrodes for In Situ Impedimetric VEGF Sensing |
| title_short | Microneedles with Interdigitated Electrodes for In Situ Impedimetric VEGF Sensing |
| title_sort | microneedles with interdigitated electrodes for in situ impedimetric vegf sensing |
| topic | biosensor capacitive microneedle VEGF |
| url | https://doi.org/10.1002/admi.202400789 |
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