Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story
The larval stage of Echinococcus granulosus causes cystic echinococcosis, a neglected infectious disease that constitutes a major public health problem in developing countries. Despite being under constant barrage by the immune system, E. granulosus modulates antiparasite immune responses and persis...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/639362 |
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| _version_ | 1832549091203088384 |
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| author | Alessandra Siracusano Federica Delunardo Antonella Teggi Elena Ortona |
| author_facet | Alessandra Siracusano Federica Delunardo Antonella Teggi Elena Ortona |
| author_sort | Alessandra Siracusano |
| collection | DOAJ |
| description | The larval stage of Echinococcus granulosus causes cystic echinococcosis, a neglected infectious disease that constitutes a major public health problem in developing countries. Despite being under constant barrage by the immune system, E. granulosus modulates antiparasite immune responses and persists in the human hosts with detectable humoral and cellular responses against the parasite. In vitro and in vivo immunological approaches, together with molecular biology and immunoproteomic technologies, provided us exciting insights into the mechanisms involved in the initiation of E. granulosus infection and the consequent induction and regulation of the immune response. Although the last decade has clarified many aspects of host-parasite relationship in human cystic echinococcosis, establishing the full mechanisms that cause the disease requires more studies. Here, we review some of the recent developments and discuss new avenues in this evolving story of E. granulosus infection in man. |
| format | Article |
| id | doaj-art-4d1b8386424745ea9717ec399d1b6cc8 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-4d1b8386424745ea9717ec399d1b6cc82025-02-03T06:12:12ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/639362639362Host-Parasite Relationship in Cystic Echinococcosis: An Evolving StoryAlessandra Siracusano0Federica Delunardo1Antonella Teggi2Elena Ortona3Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, ItalyDipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, ItalyDipartimento di Malattie Infettive e Tropicali, Ospedale Sant'Andrea, Sapienza-Università di Roma, Via di Grottarossa, 00189 Roma, ItalyDipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, ItalyThe larval stage of Echinococcus granulosus causes cystic echinococcosis, a neglected infectious disease that constitutes a major public health problem in developing countries. Despite being under constant barrage by the immune system, E. granulosus modulates antiparasite immune responses and persists in the human hosts with detectable humoral and cellular responses against the parasite. In vitro and in vivo immunological approaches, together with molecular biology and immunoproteomic technologies, provided us exciting insights into the mechanisms involved in the initiation of E. granulosus infection and the consequent induction and regulation of the immune response. Although the last decade has clarified many aspects of host-parasite relationship in human cystic echinococcosis, establishing the full mechanisms that cause the disease requires more studies. Here, we review some of the recent developments and discuss new avenues in this evolving story of E. granulosus infection in man.http://dx.doi.org/10.1155/2012/639362 |
| spellingShingle | Alessandra Siracusano Federica Delunardo Antonella Teggi Elena Ortona Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story Clinical and Developmental Immunology |
| title | Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story |
| title_full | Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story |
| title_fullStr | Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story |
| title_full_unstemmed | Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story |
| title_short | Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story |
| title_sort | host parasite relationship in cystic echinococcosis an evolving story |
| url | http://dx.doi.org/10.1155/2012/639362 |
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