Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single‐center retrospective study
Abstract Introduction Systemic inflammatory and nutritional markers are associated with the prognosis of various cancers. However, their association with sinonasal squamous cell carcinoma (SNSCC) prognosis remains unclear. This study aimed to identify systemic inflammatory and nutritional markers as...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Laryngoscope Investigative Otolaryngology |
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| Online Access: | https://doi.org/10.1002/lio2.70046 |
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| author | Ce Wu Zhiyu Qi Jiahong Chen Xudong Yan Shunke Li Lin Wang Longgang Yu Yan Jiang |
| author_facet | Ce Wu Zhiyu Qi Jiahong Chen Xudong Yan Shunke Li Lin Wang Longgang Yu Yan Jiang |
| author_sort | Ce Wu |
| collection | DOAJ |
| description | Abstract Introduction Systemic inflammatory and nutritional markers are associated with the prognosis of various cancers. However, their association with sinonasal squamous cell carcinoma (SNSCC) prognosis remains unclear. This study aimed to identify systemic inflammatory and nutritional markers associated with the postoperative prognosis of patients with SNSCC and to clarify the clinical value of these markers. Materials and methods Data from 129 patients with SNSCC were included. The optimal prognostic systemic inflammatory and nutritional markers were identified using the area under the curve. The prognostic value was evaluated using COX regression and subgroup analyses; a nomogram was built based on these data. Results The advanced lung cancer inflammation index (ALI) and systemic immune‐inflammatory index (SII) had higher prognostic values than the other indices; their cut‐off values were 27.80 and 791.35, respectively. The nomogram included tumor stage, ALI, and tumor primary site; the calibration and decision curves indicated that the model had good clinical value. Conclusion The ALI and SII have potential prognostic value for postoperative patients with SNSCC. The nomogram constructed in this study could be used as a tool to assist physicians in making clinical decisions. Level of evidence 4. |
| format | Article |
| id | doaj-art-4d12da2105c144ff87c4c68a357cd8cd |
| institution | DOAJ |
| issn | 2378-8038 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj-art-4d12da2105c144ff87c4c68a357cd8cd2025-08-20T02:45:14ZengWileyLaryngoscope Investigative Otolaryngology2378-80382025-02-01101n/an/a10.1002/lio2.70046Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single‐center retrospective studyCe Wu0Zhiyu Qi1Jiahong Chen2Xudong Yan3Shunke Li4Lin Wang5Longgang Yu6Yan Jiang7Department of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao ChinaDepartment of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao ChinaDepartment of Otolaryngology Qingdao Women and Children's Hospital Qingdao ChinaDepartment of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao ChinaDepartment of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao ChinaDepartment of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao ChinaDepartment of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao ChinaDepartment of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao ChinaAbstract Introduction Systemic inflammatory and nutritional markers are associated with the prognosis of various cancers. However, their association with sinonasal squamous cell carcinoma (SNSCC) prognosis remains unclear. This study aimed to identify systemic inflammatory and nutritional markers associated with the postoperative prognosis of patients with SNSCC and to clarify the clinical value of these markers. Materials and methods Data from 129 patients with SNSCC were included. The optimal prognostic systemic inflammatory and nutritional markers were identified using the area under the curve. The prognostic value was evaluated using COX regression and subgroup analyses; a nomogram was built based on these data. Results The advanced lung cancer inflammation index (ALI) and systemic immune‐inflammatory index (SII) had higher prognostic values than the other indices; their cut‐off values were 27.80 and 791.35, respectively. The nomogram included tumor stage, ALI, and tumor primary site; the calibration and decision curves indicated that the model had good clinical value. Conclusion The ALI and SII have potential prognostic value for postoperative patients with SNSCC. The nomogram constructed in this study could be used as a tool to assist physicians in making clinical decisions. Level of evidence 4.https://doi.org/10.1002/lio2.70046advanced lung cancer inflammation indexnomogramoverall survivalsinonasal cancersquamous cell carcinoma |
| spellingShingle | Ce Wu Zhiyu Qi Jiahong Chen Xudong Yan Shunke Li Lin Wang Longgang Yu Yan Jiang Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single‐center retrospective study Laryngoscope Investigative Otolaryngology advanced lung cancer inflammation index nomogram overall survival sinonasal cancer squamous cell carcinoma |
| title | Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single‐center retrospective study |
| title_full | Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single‐center retrospective study |
| title_fullStr | Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single‐center retrospective study |
| title_full_unstemmed | Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single‐center retrospective study |
| title_short | Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single‐center retrospective study |
| title_sort | prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma a single center retrospective study |
| topic | advanced lung cancer inflammation index nomogram overall survival sinonasal cancer squamous cell carcinoma |
| url | https://doi.org/10.1002/lio2.70046 |
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