Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis Study
Introduction. The lactate/albumin ratio is an inflammatory biomarker that has been widely used and suggested as a predictor of mortality in patients with sepsis and septic shock. However, the results are inconsistent. This meta-analysis aimed to evaluate the prognostic value of lactate/albumin ratio...
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Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2022-09-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
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| Online Access: | http://www.jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/718/340 |
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| author | Fahri Ahmad Baihaqi Dinda Olinda Delarosa Rezki Ramadhan |
| author_facet | Fahri Ahmad Baihaqi Dinda Olinda Delarosa Rezki Ramadhan |
| author_sort | Fahri Ahmad Baihaqi |
| collection | DOAJ |
| description | Introduction. The lactate/albumin ratio is an inflammatory biomarker that has been widely used and suggested as a predictor of mortality in patients with sepsis and septic shock. However, the results are inconsistent. This meta-analysis aimed to evaluate the prognostic value of lactate/albumin ratio as a predictor of mortality in patients with sepsis and septic shock.
Methods. The study protocol was registered with PROSPERO (CRD42021286242). A literature search was performed using PubMed, Ovid EMBASE, Ovid MEDLINE, SCOPUS, and Web of Sciences to find all studies evaluating the association between lactate/albumin ratio and mortality in patients with sepsis and septic shock. Meta-analysis was performed to synthesize the overall Standardized Mean Difference (SMD) of the lactate/albumin ratio and the pooled Odds Ratio (OR) for mortality with 95% confidence intervals (95% CI). Heterogeneity was assessed using I2. Publication bias was assessed quantitatively with Egger’s test. Analysis was performed using Stata version 16.
Results. Seven studies (n=10,264 patients) were included in the meta-analysis. The meta-analysis results showed that non-survivor had a higher lactate/albumin ratio than survivor (random-effects model; SMD 1.47; 95% CI 0,91-2,04; p <0.001). Higher lactate/albumin ratio was associated with an increased mortality in sepsis and septic shock patients (fixed-effects model; OR 1.49 (95% CI 1.37-1.62); p <0.001).
Conclusions. High lactate/albumin ratio was associated with mortality in sepsis and septic shock patients. Thus, lactate/albumin ratio can be used as a predictor biomarker in predicting mortality for sepsis and septic shock patients. |
| format | Article |
| id | doaj-art-4d0dc75fa6624237b5e05d4df82d4c80 |
| institution | OA Journals |
| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2022-09-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-4d0dc75fa6624237b5e05d4df82d4c802025-08-20T02:01:09ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212022-09-0193146154http://dx.doi.org/10.7454/jpdi.v9i3.718Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis StudyFahri Ahmad Baihaqi0Dinda Olinda Delarosa1Rezki Ramadhan2RSUD Serui Kabupaten Kepulauan Yapen, Provinsi Papua IndonesiaRSUP dr. Sitanala, Tangerang, Banten IndonesiaFakultas Kedokteran Universitas YARSI, Jakarta IndonesiaIntroduction. The lactate/albumin ratio is an inflammatory biomarker that has been widely used and suggested as a predictor of mortality in patients with sepsis and septic shock. However, the results are inconsistent. This meta-analysis aimed to evaluate the prognostic value of lactate/albumin ratio as a predictor of mortality in patients with sepsis and septic shock. Methods. The study protocol was registered with PROSPERO (CRD42021286242). A literature search was performed using PubMed, Ovid EMBASE, Ovid MEDLINE, SCOPUS, and Web of Sciences to find all studies evaluating the association between lactate/albumin ratio and mortality in patients with sepsis and septic shock. Meta-analysis was performed to synthesize the overall Standardized Mean Difference (SMD) of the lactate/albumin ratio and the pooled Odds Ratio (OR) for mortality with 95% confidence intervals (95% CI). Heterogeneity was assessed using I2. Publication bias was assessed quantitatively with Egger’s test. Analysis was performed using Stata version 16. Results. Seven studies (n=10,264 patients) were included in the meta-analysis. The meta-analysis results showed that non-survivor had a higher lactate/albumin ratio than survivor (random-effects model; SMD 1.47; 95% CI 0,91-2,04; p <0.001). Higher lactate/albumin ratio was associated with an increased mortality in sepsis and septic shock patients (fixed-effects model; OR 1.49 (95% CI 1.37-1.62); p <0.001). Conclusions. High lactate/albumin ratio was associated with mortality in sepsis and septic shock patients. Thus, lactate/albumin ratio can be used as a predictor biomarker in predicting mortality for sepsis and septic shock patients.http://www.jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/718/340lactate/albumin ratiometa-analysismortalitysepsisseptic shock |
| spellingShingle | Fahri Ahmad Baihaqi Dinda Olinda Delarosa Rezki Ramadhan Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis Study Jurnal Penyakit Dalam Indonesia lactate/albumin ratio meta-analysis mortality sepsis septic shock |
| title | Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis Study |
| title_full | Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis Study |
| title_fullStr | Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis Study |
| title_full_unstemmed | Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis Study |
| title_short | Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis Study |
| title_sort | lactate albumin ratio as a predictor of mortality in patients with sepsis and septic shock a meta analysis study |
| topic | lactate/albumin ratio meta-analysis mortality sepsis septic shock |
| url | http://www.jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/718/340 |
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