Thrombocytosis – a Valuable Parameter for Assessing Severity of Crohn's Disease Patients
Background and aim: Capsule endoscopy is the most sensitive method for evaluating mucosal lesions in Crohn’s disease and recent studies show that capsule endoscopy could be used for disease staging and for careful monitoring to evaluate endoscopic activity on a regular basis. Over time, many platele...
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Bucharest College of Physicians
2021-09-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2021/09/Thrombocytosis-a-Valuable-Parameter-for-Assessing-Severity-of-Crohn-s-Disease-Patients.pdf |
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| author | Ana STEMATE Teodora SPATARU Delia NEGRU-VODA Lucian NEGREANU |
| author_facet | Ana STEMATE Teodora SPATARU Delia NEGRU-VODA Lucian NEGREANU |
| author_sort | Ana STEMATE |
| collection | DOAJ |
| description | Background and aim: Capsule endoscopy is the most sensitive method for evaluating mucosal lesions in Crohn’s disease and recent studies show that capsule endoscopy could be used for disease staging and for careful monitoring to evaluate endoscopic activity on a regular basis. Over time, many platelet changes have been described in IBD, including morphological and functional alteration and increased number. We determined whether platelets count correlates with the endoscopic activity measured using capsule endoscopy in Crohn’s disease patients from a single center. Methods: This is a retrospective observational study. There were enrolled patients with suspected or known Crohn’s disease that underwent evaluation with capsule endoscopy in our department, between 2011 and 2021. For the evaluation with capsule endoscopy, Pillcam SB3 or Pillcam Colon2 were used. For the evaluation of endoscopic activity, we used Lewis score calculated using RAPID 8 capsule-reading software. Platelets level was measured and correlated with the Lewis score, inflammatory biomarkers (C-reactive protein and fecal calprotectin) and anemic syndrome. Results: A total of 62 patients were included in the study, of whom 37 (59.67%) were with suspected Crohn’s disease and 25 (40.32%) were with known Crohn’s disease. Thrombocytosis was present in the majority of patients with severe endoscopic activity (Lewis score more than 790), elevated CRP, fecal calprotectin more than 250microg/g and anemic syndrome. Conclusion: To our knowledge, this is the first study that assess the correlation between thrombocytosis and severity of Crohn’s disease, evaluated with capsule endoscopy. Our data suggests that platelet count is a valuable, non-invasive, easy to use biomarker that is a good predictor of severity of Crohn’s disease and could have a prognostic value. It correlates well with Lewis score, CRP, fecal calprotectin and anemia. |
| format | Article |
| id | doaj-art-4d0b5add8bf549cd8c71a69644c749d1 |
| institution | OA Journals |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-4d0b5add8bf549cd8c71a69644c749d12025-08-20T02:17:40ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732021-09-01283301306https://doi.org/10.31689/rmm.2021.28.3.301Thrombocytosis – a Valuable Parameter for Assessing Severity of Crohn's Disease PatientsAna STEMATE0https://orcid.org/0000-0003-2935-5406Teodora SPATARU1Delia NEGRU-VODA2Lucian NEGREANU3https://orcid.org/0000-0003-3042-0754Department of Gastroenterology 2, Emergency University Hospital, „Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Gastroenterology 2, Emergency University Hospital, „Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Gastroenterology 2, Emergency University Hospital, „Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Gastroenterology 2, Emergency University Hospital, „Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaBackground and aim: Capsule endoscopy is the most sensitive method for evaluating mucosal lesions in Crohn’s disease and recent studies show that capsule endoscopy could be used for disease staging and for careful monitoring to evaluate endoscopic activity on a regular basis. Over time, many platelet changes have been described in IBD, including morphological and functional alteration and increased number. We determined whether platelets count correlates with the endoscopic activity measured using capsule endoscopy in Crohn’s disease patients from a single center. Methods: This is a retrospective observational study. There were enrolled patients with suspected or known Crohn’s disease that underwent evaluation with capsule endoscopy in our department, between 2011 and 2021. For the evaluation with capsule endoscopy, Pillcam SB3 or Pillcam Colon2 were used. For the evaluation of endoscopic activity, we used Lewis score calculated using RAPID 8 capsule-reading software. Platelets level was measured and correlated with the Lewis score, inflammatory biomarkers (C-reactive protein and fecal calprotectin) and anemic syndrome. Results: A total of 62 patients were included in the study, of whom 37 (59.67%) were with suspected Crohn’s disease and 25 (40.32%) were with known Crohn’s disease. Thrombocytosis was present in the majority of patients with severe endoscopic activity (Lewis score more than 790), elevated CRP, fecal calprotectin more than 250microg/g and anemic syndrome. Conclusion: To our knowledge, this is the first study that assess the correlation between thrombocytosis and severity of Crohn’s disease, evaluated with capsule endoscopy. Our data suggests that platelet count is a valuable, non-invasive, easy to use biomarker that is a good predictor of severity of Crohn’s disease and could have a prognostic value. It correlates well with Lewis score, CRP, fecal calprotectin and anemia.https://medicinamoderna.ro/wp-content/uploads/2021/09/Thrombocytosis-a-Valuable-Parameter-for-Assessing-Severity-of-Crohn-s-Disease-Patients.pdfcapsule endoscopyinflammatory bowel diseasecrohn’s diseasethrombocytosisplatelet count |
| spellingShingle | Ana STEMATE Teodora SPATARU Delia NEGRU-VODA Lucian NEGREANU Thrombocytosis – a Valuable Parameter for Assessing Severity of Crohn's Disease Patients Modern Medicine capsule endoscopy inflammatory bowel disease crohn’s disease thrombocytosis platelet count |
| title | Thrombocytosis – a Valuable Parameter for Assessing Severity of Crohn's Disease Patients |
| title_full | Thrombocytosis – a Valuable Parameter for Assessing Severity of Crohn's Disease Patients |
| title_fullStr | Thrombocytosis – a Valuable Parameter for Assessing Severity of Crohn's Disease Patients |
| title_full_unstemmed | Thrombocytosis – a Valuable Parameter for Assessing Severity of Crohn's Disease Patients |
| title_short | Thrombocytosis – a Valuable Parameter for Assessing Severity of Crohn's Disease Patients |
| title_sort | thrombocytosis a valuable parameter for assessing severity of crohn s disease patients |
| topic | capsule endoscopy inflammatory bowel disease crohn’s disease thrombocytosis platelet count |
| url | https://medicinamoderna.ro/wp-content/uploads/2021/09/Thrombocytosis-a-Valuable-Parameter-for-Assessing-Severity-of-Crohn-s-Disease-Patients.pdf |
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