Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA Methylation
Alzheimer’s disease (AD) is a chronic neurodegenerative disease in the central nervous system that has complex pathogenesis in the elderly. The current review focuses on the epigenetic mechanisms of AD, according to the latest findings. One of the best-characterized chromatin modifications in epigen...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2020/8438602 |
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| author | Tingting Pi Bo Liu Jingshan Shi |
| author_facet | Tingting Pi Bo Liu Jingshan Shi |
| author_sort | Tingting Pi |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a chronic neurodegenerative disease in the central nervous system that has complex pathogenesis in the elderly. The current review focuses on the epigenetic mechanisms of AD, according to the latest findings. One of the best-characterized chromatin modifications in epigenetic mechanisms is DNA methylation. Highly replicable data shows that AD occurrence is often accompanied by methylation level changes of the AD-related gene. Homocysteine (Hcy) is not only an intermediate product of one-carbon metabolism but also an important independent risk factor of AD; it can affect the cognitive function of the brain by changing the one-carbon metabolism and interfering with the DNA methylation process, resulting in cerebrovascular disease. In general, Hcy may be an environmental factor that affects AD via the DNA methylation pathway with a series of changes in AD-related substance. This review will concentrate on the relation between DNA methylation and Hcy and try to figure out their rule in the pathophysiology of AD. |
| format | Article |
| id | doaj-art-4d09b2d6dee54271802cffec39655433 |
| institution | OA Journals |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-4d09b2d6dee54271802cffec396554332025-08-20T02:38:38ZengWileyBehavioural Neurology0953-41801875-85842020-01-01202010.1155/2020/84386028438602Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA MethylationTingting Pi0Bo Liu1Jingshan Shi2Department of Pharmacology and the Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Pharmacology and the Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Pharmacology and the Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi 563000, ChinaAlzheimer’s disease (AD) is a chronic neurodegenerative disease in the central nervous system that has complex pathogenesis in the elderly. The current review focuses on the epigenetic mechanisms of AD, according to the latest findings. One of the best-characterized chromatin modifications in epigenetic mechanisms is DNA methylation. Highly replicable data shows that AD occurrence is often accompanied by methylation level changes of the AD-related gene. Homocysteine (Hcy) is not only an intermediate product of one-carbon metabolism but also an important independent risk factor of AD; it can affect the cognitive function of the brain by changing the one-carbon metabolism and interfering with the DNA methylation process, resulting in cerebrovascular disease. In general, Hcy may be an environmental factor that affects AD via the DNA methylation pathway with a series of changes in AD-related substance. This review will concentrate on the relation between DNA methylation and Hcy and try to figure out their rule in the pathophysiology of AD.http://dx.doi.org/10.1155/2020/8438602 |
| spellingShingle | Tingting Pi Bo Liu Jingshan Shi Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA Methylation Behavioural Neurology |
| title | Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA Methylation |
| title_full | Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA Methylation |
| title_fullStr | Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA Methylation |
| title_full_unstemmed | Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA Methylation |
| title_short | Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA Methylation |
| title_sort | abnormal homocysteine metabolism an insight of alzheimer s disease from dna methylation |
| url | http://dx.doi.org/10.1155/2020/8438602 |
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