Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells
Hepatocellular carcinoma is the most common subtype of liver cancer. Protein arginine N-methyltransferase 1 was shown to be upregulated in various cancers. However, the role of protein arginine N-methyltransferase 1 in hepatocellular carcinoma progression remains incompletely understood. We investig...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-02-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317691419 |
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| _version_ | 1850052454292389888 |
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| author | Qing Gou ShuJiao He ZeJian Zhou |
| author_facet | Qing Gou ShuJiao He ZeJian Zhou |
| author_sort | Qing Gou |
| collection | DOAJ |
| description | Hepatocellular carcinoma is the most common subtype of liver cancer. Protein arginine N-methyltransferase 1 was shown to be upregulated in various cancers. However, the role of protein arginine N-methyltransferase 1 in hepatocellular carcinoma progression remains incompletely understood. We investigated the clinical and functional significance of protein arginine N-methyltransferase 1 in a series of clinical hepatocellular carcinoma samples and a panel of hepatocellular carcinoma cell lines. We performed suppression analysis of protein arginine N-methyltransferase 1 using small interfering RNA to determine the biological roles of protein arginine N-methyltransferase 1 in hepatocellular carcinoma. In addition, the expression of epithelial-mesenchymal transition indicators was verified by western blotting in hepatocellular carcinoma cell lines after small interfering RNA treatment. Protein arginine N-methyltransferase 1 expression was found to be significantly upregulated in hepatocellular carcinoma cell lines and clinical tissues. Moreover, downregulation of protein arginine N-methyltransferase 1 in hepatocellular carcinoma cells by small interfering RNA could inhibit cell proliferation, migration, and invasion in vitro. These results indicate that protein arginine N-methyltransferase 1 may contribute to hepatocellular carcinoma progression and serves as a promising target for the treatment of hepatocellular carcinoma patients. |
| format | Article |
| id | doaj-art-4d01ff3c927641b2a58bbaddb783e41a |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-4d01ff3c927641b2a58bbaddb783e41a2025-08-20T02:52:48ZengSAGE PublishingTumor Biology1423-03802017-02-013910.1177/1010428317691419Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cellsQing Gou0ShuJiao He1ZeJian Zhou2Department of Interventional Radiology, Cancer Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, P.R. ChinaDepartment of Cancer Center, Chinese Medicine-Integrated Hospital, Guangzhou, P.R. ChinaDepartment of Interventional Radiology, Cancer Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, P.R. ChinaHepatocellular carcinoma is the most common subtype of liver cancer. Protein arginine N-methyltransferase 1 was shown to be upregulated in various cancers. However, the role of protein arginine N-methyltransferase 1 in hepatocellular carcinoma progression remains incompletely understood. We investigated the clinical and functional significance of protein arginine N-methyltransferase 1 in a series of clinical hepatocellular carcinoma samples and a panel of hepatocellular carcinoma cell lines. We performed suppression analysis of protein arginine N-methyltransferase 1 using small interfering RNA to determine the biological roles of protein arginine N-methyltransferase 1 in hepatocellular carcinoma. In addition, the expression of epithelial-mesenchymal transition indicators was verified by western blotting in hepatocellular carcinoma cell lines after small interfering RNA treatment. Protein arginine N-methyltransferase 1 expression was found to be significantly upregulated in hepatocellular carcinoma cell lines and clinical tissues. Moreover, downregulation of protein arginine N-methyltransferase 1 in hepatocellular carcinoma cells by small interfering RNA could inhibit cell proliferation, migration, and invasion in vitro. These results indicate that protein arginine N-methyltransferase 1 may contribute to hepatocellular carcinoma progression and serves as a promising target for the treatment of hepatocellular carcinoma patients.https://doi.org/10.1177/1010428317691419 |
| spellingShingle | Qing Gou ShuJiao He ZeJian Zhou Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells Tumor Biology |
| title | Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells |
| title_full | Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells |
| title_fullStr | Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells |
| title_full_unstemmed | Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells |
| title_short | Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells |
| title_sort | protein arginine n methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells |
| url | https://doi.org/10.1177/1010428317691419 |
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