Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis—a pilot study in adult patients
Abstract Monitoring intraperitoneal pressure (IPP) offers valuable insights into changes of intraperitoneal volume (IPV) during peritoneal dialysis (PD). This study aims to investigate the relationship between IPV and IPP during a PD dwell. Thirteen patients were studied during a 2‐h dwell using 2 L...
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Wiley
2025-03-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70179 |
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| author | Fansan Zhu Laura Rosales Merlo Lela Tisdale Maricar Villarama Jun Yi Zahin Haq Xiaoling Wang Nadja Grobe Karsten Fischer Kulwinder Plahey Richard A. Lasher Paul Chamney Brigitte Schiller Peter Kotanko |
| author_facet | Fansan Zhu Laura Rosales Merlo Lela Tisdale Maricar Villarama Jun Yi Zahin Haq Xiaoling Wang Nadja Grobe Karsten Fischer Kulwinder Plahey Richard A. Lasher Paul Chamney Brigitte Schiller Peter Kotanko |
| author_sort | Fansan Zhu |
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| description | Abstract Monitoring intraperitoneal pressure (IPP) offers valuable insights into changes of intraperitoneal volume (IPV) during peritoneal dialysis (PD). This study aims to investigate the relationship between IPV and IPP during a PD dwell. Thirteen patients were studied during a 2‐h dwell using 2 L of dialysate containing 2.5% dextrose. IPP was measured using a pressure sensor integrated into an automated PD cycler. IPV was monitored concurrently by segmental bioimpedance (Hydra 4200). The density (ρ) of the PD dialysate was measured using a meter, and the creatinine and glucose concentrations in both dialysate (D) and serum (P) were measured pre‐ and post‐PD dwell. A physical model (IPP = ρ × g × h), was used to describe the relationship between IPP and IPV, where h is the apparent dialysate height and g is the gravitational acceleration. The change in IPP (ΔIPP, −21.2 ± 18%) was mainly determined by the change of h (Δh, −20.9 ± 18.5%), while the change ρ (Δρ, −0.34 ± 0.06%), was minor. The study demonstrated an association between ΔIPP and the ratio of D/P creatinine and D/D0 glucose, suggesting that ΔIPP may reflect membrane transport characteristics. Due to its noninvasive and seamless nature, the clinical utility of PD cycler‐based measurement of IPP warrants further exploration. |
| format | Article |
| id | doaj-art-4cfe4aa0ab4b4d4284c863ad89fa2457 |
| institution | DOAJ |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-4cfe4aa0ab4b4d4284c863ad89fa24572025-08-20T03:05:43ZengWileyPhysiological Reports2051-817X2025-03-01135n/an/a10.14814/phy2.70179Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis—a pilot study in adult patientsFansan Zhu0Laura Rosales Merlo1Lela Tisdale2Maricar Villarama3Jun Yi4Zahin Haq5Xiaoling Wang6Nadja Grobe7Karsten Fischer8Kulwinder Plahey9Richard A. Lasher10Paul Chamney11Brigitte Schiller12Peter Kotanko13Renal Research Institute New York City New York USARenal Research Institute New York City New York USARenal Research Institute New York City New York USAMount Sinai Hospital New York City New York USAFresenius Medical Care North America Waltham Massachusetts USARenal Research Institute New York City New York USARenal Research Institute New York City New York USARenal Research Institute New York City New York USAFresenius Medical Care North America Waltham Massachusetts USAFresenius Medical Care North America Waltham Massachusetts USAFresenius Medical Care North America Waltham Massachusetts USAFresenius Medical Care AG Bad Homburg GermanyFresenius Medical Care North America Waltham Massachusetts USARenal Research Institute New York City New York USAAbstract Monitoring intraperitoneal pressure (IPP) offers valuable insights into changes of intraperitoneal volume (IPV) during peritoneal dialysis (PD). This study aims to investigate the relationship between IPV and IPP during a PD dwell. Thirteen patients were studied during a 2‐h dwell using 2 L of dialysate containing 2.5% dextrose. IPP was measured using a pressure sensor integrated into an automated PD cycler. IPV was monitored concurrently by segmental bioimpedance (Hydra 4200). The density (ρ) of the PD dialysate was measured using a meter, and the creatinine and glucose concentrations in both dialysate (D) and serum (P) were measured pre‐ and post‐PD dwell. A physical model (IPP = ρ × g × h), was used to describe the relationship between IPP and IPV, where h is the apparent dialysate height and g is the gravitational acceleration. The change in IPP (ΔIPP, −21.2 ± 18%) was mainly determined by the change of h (Δh, −20.9 ± 18.5%), while the change ρ (Δρ, −0.34 ± 0.06%), was minor. The study demonstrated an association between ΔIPP and the ratio of D/P creatinine and D/D0 glucose, suggesting that ΔIPP may reflect membrane transport characteristics. Due to its noninvasive and seamless nature, the clinical utility of PD cycler‐based measurement of IPP warrants further exploration.https://doi.org/10.14814/phy2.70179bioimpedanceintraperitoneal pressureintraperitoneal volumeperitoneal dialysisultrafiltration |
| spellingShingle | Fansan Zhu Laura Rosales Merlo Lela Tisdale Maricar Villarama Jun Yi Zahin Haq Xiaoling Wang Nadja Grobe Karsten Fischer Kulwinder Plahey Richard A. Lasher Paul Chamney Brigitte Schiller Peter Kotanko Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis—a pilot study in adult patients Physiological Reports bioimpedance intraperitoneal pressure intraperitoneal volume peritoneal dialysis ultrafiltration |
| title | Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis—a pilot study in adult patients |
| title_full | Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis—a pilot study in adult patients |
| title_fullStr | Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis—a pilot study in adult patients |
| title_full_unstemmed | Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis—a pilot study in adult patients |
| title_short | Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis—a pilot study in adult patients |
| title_sort | relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis a pilot study in adult patients |
| topic | bioimpedance intraperitoneal pressure intraperitoneal volume peritoneal dialysis ultrafiltration |
| url | https://doi.org/10.14814/phy2.70179 |
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