Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer: Insights from the ASKHER2 European survey
Background: Perceived risk and fear of recurrence in patients with breast cancer (BC) is a matter of concern and may affect their health behaviours and their ability to participate in decision making during their treatment. This survey aimed to examine perceptions and concerns of patients with HER2+...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977625004734 |
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| author | Matteo Lambertini Christian Jackisch Olivier Trédan Maria Vidal Mário Fontes-Sousa Antonios Valachis Rosanna D'Antona Marcelo Ruz Eugenia Krone Miriam Brice Erwan Berjonneau Soraia Matos Olivia Dialla Laure Guéroult-Accolas |
| author_facet | Matteo Lambertini Christian Jackisch Olivier Trédan Maria Vidal Mário Fontes-Sousa Antonios Valachis Rosanna D'Antona Marcelo Ruz Eugenia Krone Miriam Brice Erwan Berjonneau Soraia Matos Olivia Dialla Laure Guéroult-Accolas |
| author_sort | Matteo Lambertini |
| collection | DOAJ |
| description | Background: Perceived risk and fear of recurrence in patients with breast cancer (BC) is a matter of concern and may affect their health behaviours and their ability to participate in decision making during their treatment. This survey aimed to examine perceptions and concerns of patients with HER2+ BC. Materials and methods: A multi-country, non-interventional, direct-to-patient online survey was conducted between July 22, 2022 and March 1, 2023 in six European countries using a multi-modal recruitment approach. Results: Out of 622 included patients, 96.8 % desired involvement in treatment decisions, and 58.5 % felt they had significant influence in the decision-making process. A total of 20.9 % of patients were unaware of their personal risk of recurrence, and 19.5 % reported not discussing this risk with their healthcare providers. The fear of disease recurrence, death, and treatment failure were identified as the most important concerns. Moreover, 30.4 % perceived they had clear communication with healthcare providers on risk of recurrence. A total of 64.5 % were willing to take extra treatments, 60.2 % to undergo more surgery to reduce recurrence risk and 68.5 % were willing to accept further treatments even if recurrence risk decreased by less than 50 %. Conclusion: Results of this multinational direct-to-patient study examining the perceptions and concerns of women with HER2+ breast cancer underscore the need for physicians to proactively involve patients in their decision-making process, enabling them to participate in a patient-centred approach during treatment decisions. |
| format | Article |
| id | doaj-art-4cfd64da8c194e1bad96343ceda81b53 |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-4cfd64da8c194e1bad96343ceda81b532025-08-20T03:49:44ZengElsevierBreast1532-30802025-06-018110445610.1016/j.breast.2025.104456Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer: Insights from the ASKHER2 European surveyMatteo Lambertini0Christian Jackisch1Olivier Trédan2Maria Vidal3Mário Fontes-Sousa4Antonios Valachis5Rosanna D'Antona6Marcelo Ruz7Eugenia Krone8Miriam Brice9Erwan Berjonneau10Soraia Matos11Olivia Dialla12Laure Guéroult-Accolas13Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genoa, Italy; Department of Medical Oncology, U.O.C. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genoa, 16132, Italy; Corresponding author. Medical Oncology Department, U.O.C. Clinica di Oncologia Medica IRCCS Policlinico San Martino Hospital – University of Genova, Largo Rosanna Benzi 10 – 16132 Genova, Italy.Kliniken Essen Mitte gGmbH – KEM- Essen, GermanyCentre Léon Bérard, France; Cancer Research Center of Lyon (UMR Inserm 1052 – CNRS 5286), FranceIOB Institute of Oncology Barcelona, SpainCUF Tejo, Lisboa, Portugal; Hospital S. Francisco Xavier, ULSLO, Lisboa, PortugalDepartment of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, SwedenEuropa Donna Italia, ItalyAMOH, SpainMamazone, GermanyCareca Power, PortugalCerner Enviza / Oracle, FrancePierre Fabre Médicament, FrancePierre Fabre Médicament, FrancePatient en Réseau, FranceBackground: Perceived risk and fear of recurrence in patients with breast cancer (BC) is a matter of concern and may affect their health behaviours and their ability to participate in decision making during their treatment. This survey aimed to examine perceptions and concerns of patients with HER2+ BC. Materials and methods: A multi-country, non-interventional, direct-to-patient online survey was conducted between July 22, 2022 and March 1, 2023 in six European countries using a multi-modal recruitment approach. Results: Out of 622 included patients, 96.8 % desired involvement in treatment decisions, and 58.5 % felt they had significant influence in the decision-making process. A total of 20.9 % of patients were unaware of their personal risk of recurrence, and 19.5 % reported not discussing this risk with their healthcare providers. The fear of disease recurrence, death, and treatment failure were identified as the most important concerns. Moreover, 30.4 % perceived they had clear communication with healthcare providers on risk of recurrence. A total of 64.5 % were willing to take extra treatments, 60.2 % to undergo more surgery to reduce recurrence risk and 68.5 % were willing to accept further treatments even if recurrence risk decreased by less than 50 %. Conclusion: Results of this multinational direct-to-patient study examining the perceptions and concerns of women with HER2+ breast cancer underscore the need for physicians to proactively involve patients in their decision-making process, enabling them to participate in a patient-centred approach during treatment decisions.http://www.sciencedirect.com/science/article/pii/S0960977625004734HER2+Breast cancerRisk of recurrencePatient perceptionCommunicationIntervention |
| spellingShingle | Matteo Lambertini Christian Jackisch Olivier Trédan Maria Vidal Mário Fontes-Sousa Antonios Valachis Rosanna D'Antona Marcelo Ruz Eugenia Krone Miriam Brice Erwan Berjonneau Soraia Matos Olivia Dialla Laure Guéroult-Accolas Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer: Insights from the ASKHER2 European survey Breast HER2+ Breast cancer Risk of recurrence Patient perception Communication Intervention |
| title | Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer: Insights from the ASKHER2 European survey |
| title_full | Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer: Insights from the ASKHER2 European survey |
| title_fullStr | Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer: Insights from the ASKHER2 European survey |
| title_full_unstemmed | Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer: Insights from the ASKHER2 European survey |
| title_short | Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer: Insights from the ASKHER2 European survey |
| title_sort | patient perception on risk of recurrence and decision making in the management of her2 positive early breast cancer insights from the askher2 european survey |
| topic | HER2+ Breast cancer Risk of recurrence Patient perception Communication Intervention |
| url | http://www.sciencedirect.com/science/article/pii/S0960977625004734 |
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