Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia
BackgroundSepsis in the neonatal period is a major health challenge in neonatal medicine because of its potential for rapid progression to multi-organ dysfunction, leading to higher morbidity and mortality. Although efforts have been made to advance the outcomes of neonates admitted to hospitals, th...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1434803/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591571505119232 |
|---|---|
| author | Betelhem Gezahegn Ahmed Abdella Fentahun Meseret Ahmed Mohammed Mulualem Keneni Tesfaye Asfaw Diribsa Tizazu Assefa Desalew |
| author_facet | Betelhem Gezahegn Ahmed Abdella Fentahun Meseret Ahmed Mohammed Mulualem Keneni Tesfaye Asfaw Diribsa Tizazu Assefa Desalew |
| author_sort | Betelhem Gezahegn |
| collection | DOAJ |
| description | BackgroundSepsis in the neonatal period is a major health challenge in neonatal medicine because of its potential for rapid progression to multi-organ dysfunction, leading to higher morbidity and mortality. Although efforts have been made to advance the outcomes of neonates admitted to hospitals, there is a paucity of data regarding neonatal sepsis treatment outcomes in the study setting. Hence, the study aimed to assess outcomes and prognostic factors of sepsis among neonatal patients admitted to the neonatal intensive care unit in Hiwot Fana Comprehensive Specialized University Hospital in Ethiopia.MethodsA facility-based cross-sectional study was conducted among 311 neonates with sepsis admitted from 1 January 2021 to 30 December 2023. Neonates were selected using systematic random sampling. Relevant data were extracted from medical records using a checklist. The data were entered into EpiData version 4.6 and analyzed using STATA version 17. Bivariable and multivariable logistic regression analyses were performed to identify factors associated with the outcome variable.ResultsEighty-four of 311 patients (27.8%) (95% CI: 22.7%–32.9%) died, while 218 (72.2%) were discharged after improvement. In the multivariable logistic regression analysis, low white blood cell (WBC) count [adjusted odds ratio (AOR) = 4.24, 95% CI: 1.5–12.5], desaturation (aOR = 3.00, 95% CI: 1.6–5.5), pre-term birth (aOR = 2.14, 95% CI: 1.1–4.0), lack of maternal antenatal care (ANC) follow-up (aOR = 2.4, 95% CI: 1.2–4.7), and chorioamnionitis (aOR = 2.8, 95% CI: 1.2–6.5) were significantly associated with neonatal sepsis mortality.ConclusionApproximately one-quarter of patients with neonatal sepsis died. The significant prognostic factors for sepsis were found to be low WBC count, desaturation, lack of ANC visits, and chorioamnionitis. Implementing targeted therapeutic interventions and addressing these prognostic factors could improve treatment outcomes. |
| format | Article |
| id | doaj-art-4cf8e1c649aa43cda1d5d539eb73d0e0 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-4cf8e1c649aa43cda1d5d539eb73d0e02025-01-22T10:33:39ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.14348031434803Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, EthiopiaBetelhem Gezahegn0Ahmed Abdella1Fentahun Meseret2Ahmed Mohammed3Mulualem Keneni4Tesfaye Asfaw5Diribsa Tizazu6Assefa Desalew7Department of Pediatrics and Child Health, Sabian General Hospital, Dire Dawa, EthiopiaDepartment of Pediatrics and Child Health, School of Medicine, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaDepartment of Pediatrics and Child Health Nursing, School of Nursing, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaDepartment of Pediatrics and Child Health, School of Medicine, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaDepartment of Pediatrics and Child Health Nursing, School of Nursing, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaDepartment of Pediatrics and Child Health Nursing, School of Nursing, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaDepartment of Pediatrics and Child Health Nursing, School of Nursing, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaDepartment of Pediatrics and Child Health Nursing, School of Nursing, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaBackgroundSepsis in the neonatal period is a major health challenge in neonatal medicine because of its potential for rapid progression to multi-organ dysfunction, leading to higher morbidity and mortality. Although efforts have been made to advance the outcomes of neonates admitted to hospitals, there is a paucity of data regarding neonatal sepsis treatment outcomes in the study setting. Hence, the study aimed to assess outcomes and prognostic factors of sepsis among neonatal patients admitted to the neonatal intensive care unit in Hiwot Fana Comprehensive Specialized University Hospital in Ethiopia.MethodsA facility-based cross-sectional study was conducted among 311 neonates with sepsis admitted from 1 January 2021 to 30 December 2023. Neonates were selected using systematic random sampling. Relevant data were extracted from medical records using a checklist. The data were entered into EpiData version 4.6 and analyzed using STATA version 17. Bivariable and multivariable logistic regression analyses were performed to identify factors associated with the outcome variable.ResultsEighty-four of 311 patients (27.8%) (95% CI: 22.7%–32.9%) died, while 218 (72.2%) were discharged after improvement. In the multivariable logistic regression analysis, low white blood cell (WBC) count [adjusted odds ratio (AOR) = 4.24, 95% CI: 1.5–12.5], desaturation (aOR = 3.00, 95% CI: 1.6–5.5), pre-term birth (aOR = 2.14, 95% CI: 1.1–4.0), lack of maternal antenatal care (ANC) follow-up (aOR = 2.4, 95% CI: 1.2–4.7), and chorioamnionitis (aOR = 2.8, 95% CI: 1.2–6.5) were significantly associated with neonatal sepsis mortality.ConclusionApproximately one-quarter of patients with neonatal sepsis died. The significant prognostic factors for sepsis were found to be low WBC count, desaturation, lack of ANC visits, and chorioamnionitis. Implementing targeted therapeutic interventions and addressing these prognostic factors could improve treatment outcomes.https://www.frontiersin.org/articles/10.3389/fped.2024.1434803/fullneonatal sepsistreatment outcomesHiwot Fana Comprehensive Specialized University HospitalHararEthiopia |
| spellingShingle | Betelhem Gezahegn Ahmed Abdella Fentahun Meseret Ahmed Mohammed Mulualem Keneni Tesfaye Asfaw Diribsa Tizazu Assefa Desalew Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia Frontiers in Pediatrics neonatal sepsis treatment outcomes Hiwot Fana Comprehensive Specialized University Hospital Harar Ethiopia |
| title | Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia |
| title_full | Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia |
| title_fullStr | Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia |
| title_full_unstemmed | Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia |
| title_short | Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia |
| title_sort | treatment outcomes and its associated factors among neonates admitted with sepsis in hiwot fana comprehensive specialized university hospital harar ethiopia |
| topic | neonatal sepsis treatment outcomes Hiwot Fana Comprehensive Specialized University Hospital Harar Ethiopia |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1434803/full |
| work_keys_str_mv | AT betelhemgezahegn treatmentoutcomesanditsassociatedfactorsamongneonatesadmittedwithsepsisinhiwotfanacomprehensivespecializeduniversityhospitalhararethiopia AT ahmedabdella treatmentoutcomesanditsassociatedfactorsamongneonatesadmittedwithsepsisinhiwotfanacomprehensivespecializeduniversityhospitalhararethiopia AT fentahunmeseret treatmentoutcomesanditsassociatedfactorsamongneonatesadmittedwithsepsisinhiwotfanacomprehensivespecializeduniversityhospitalhararethiopia AT ahmedmohammed treatmentoutcomesanditsassociatedfactorsamongneonatesadmittedwithsepsisinhiwotfanacomprehensivespecializeduniversityhospitalhararethiopia AT mulualemkeneni treatmentoutcomesanditsassociatedfactorsamongneonatesadmittedwithsepsisinhiwotfanacomprehensivespecializeduniversityhospitalhararethiopia AT tesfayeasfaw treatmentoutcomesanditsassociatedfactorsamongneonatesadmittedwithsepsisinhiwotfanacomprehensivespecializeduniversityhospitalhararethiopia AT diribsatizazu treatmentoutcomesanditsassociatedfactorsamongneonatesadmittedwithsepsisinhiwotfanacomprehensivespecializeduniversityhospitalhararethiopia AT assefadesalew treatmentoutcomesanditsassociatedfactorsamongneonatesadmittedwithsepsisinhiwotfanacomprehensivespecializeduniversityhospitalhararethiopia |