Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure

Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure

Abstract Pressure overload initiates a series of alterations in the human heart that predate macroscopic organ-level remodeling and downstream heart failure. We study aortic stenosis through integrated proteomic, tissue transcriptomic, and genetic methods to prioritize targets causal in human heart...

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Main Authors: Brian R. Lindman, Andrew S. Perry, Michelle L. Lance, Kaushik Amancherla, Namju Kim, Quanhu Sheng, Phillip Lin, Ryan D. Pfeiffer, Eric Farber-Eger, William F. Fearon, Samir Kapadia, Dharam J. Kumbhani, Linda Gillam, Ravinder R. Mallugari, Deepak K. Gupta, Francis J. Miller, Anna Vatterott, Natalie Jackson, Yan Ru Su, Kelsey Tomasek, Tarek Absi, Jane E. Freedman, Matthew Nayor, Saumya Das, Quinn S. Wells, Marc R. Dweck, Robert E. Gerszten, Eric R. Gamazon, Nathan R. Tucker, Ravi Shah, Sammy Elmariah
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62201-2
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