Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRI
Abstract Purpose To investigate the utility of qualitative and semi-quantitative evaluation of DCE-MRI for detecting clinically significant prostate cancer (csPC). Methods This retrospective study analyzed 307 lesions in 231 patients who underwent 3.0T MRI. Experienced radiologists assessed PI-RADS...
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| Format: | Article |
| Language: | English |
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Springer
2024-12-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01668-9 |
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| author | Tsutomu Tamada Mitsuru Takeuchi Hiroyuki Watanabe Atsushi Higaki Kazunori Moriya Akihiko Kanki Yoshihiko Fukukura Akira Yamamoto |
| author_facet | Tsutomu Tamada Mitsuru Takeuchi Hiroyuki Watanabe Atsushi Higaki Kazunori Moriya Akihiko Kanki Yoshihiko Fukukura Akira Yamamoto |
| author_sort | Tsutomu Tamada |
| collection | DOAJ |
| description | Abstract Purpose To investigate the utility of qualitative and semi-quantitative evaluation of DCE-MRI for detecting clinically significant prostate cancer (csPC). Methods This retrospective study analyzed 307 lesions in 231 patients who underwent 3.0T MRI. Experienced radiologists assessed PI-RADS v 2.1 assessment category, qualitative contrast enhancement (QCE), contrast enhancement pattern (CEP: type 1, 2, 3), tumor contrast ratio, and tumor size of PC lesions in consensus. Mean and 0–10th-percentile ADC value of the lesion (ADCmean and ADC0−10) were calculated. Specimens obtained from MRI–ultrasound fusion-guided prostate biopsy were used as the pathological reference standard. Results In assessment of tumor aggressiveness, PI-RADS assessment category, QCE, tumor size, and ratio of CEP 2 + 3 were significantly higher in PC with Gleason score (GS) ≥ 3 + 4 (n = 256) than in PC with GS = 6 (n = 51) (P ≤ 0.001). Tumor ADCmean and tumor ADC0−10 were comparable between PC with GS ≥ 3 + 4 and PC with GS = 6 (P = 0.164 to 0.504). Regarding diagnostic performance of csPC in 45 PI-RADS 3 transition zone lesions, only ratio of CEP 2 + 3 was significantly higher in PC with GS ≥ 3 + 4 (n = 31) than in PC with GS = 6 (n = 14) (P = 0.008). Conclusion Qualitative DCE-MRI indices may contribute to PC aggressiveness and improve detection of csPC in PI-RADS assessment category 3 lesions. |
| format | Article |
| id | doaj-art-4cf5b73da8614ae3ae3d650a8cdbfe68 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-4cf5b73da8614ae3ae3d650a8cdbfe682025-08-20T02:31:48ZengSpringerDiscover Oncology2730-60112024-12-0115111410.1007/s12672-024-01668-9Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRITsutomu Tamada0Mitsuru Takeuchi1Hiroyuki Watanabe2Atsushi Higaki3Kazunori Moriya4Akihiko Kanki5Yoshihiko Fukukura6Akira Yamamoto7Department of Radiology, Kawasaki Medical SchoolDepartment of Radiology, Kawasaki Medical SchoolDepartment of Radiology, Kawasaki Medical SchoolDepartment of Radiology, Kawasaki Medical SchoolDepartment of Radiology, Kawasaki Medical SchoolDepartment of Radiology, Kawasaki Medical SchoolDepartment of Radiology, Kawasaki Medical SchoolDepartment of Radiology, Kawasaki Medical SchoolAbstract Purpose To investigate the utility of qualitative and semi-quantitative evaluation of DCE-MRI for detecting clinically significant prostate cancer (csPC). Methods This retrospective study analyzed 307 lesions in 231 patients who underwent 3.0T MRI. Experienced radiologists assessed PI-RADS v 2.1 assessment category, qualitative contrast enhancement (QCE), contrast enhancement pattern (CEP: type 1, 2, 3), tumor contrast ratio, and tumor size of PC lesions in consensus. Mean and 0–10th-percentile ADC value of the lesion (ADCmean and ADC0−10) were calculated. Specimens obtained from MRI–ultrasound fusion-guided prostate biopsy were used as the pathological reference standard. Results In assessment of tumor aggressiveness, PI-RADS assessment category, QCE, tumor size, and ratio of CEP 2 + 3 were significantly higher in PC with Gleason score (GS) ≥ 3 + 4 (n = 256) than in PC with GS = 6 (n = 51) (P ≤ 0.001). Tumor ADCmean and tumor ADC0−10 were comparable between PC with GS ≥ 3 + 4 and PC with GS = 6 (P = 0.164 to 0.504). Regarding diagnostic performance of csPC in 45 PI-RADS 3 transition zone lesions, only ratio of CEP 2 + 3 was significantly higher in PC with GS ≥ 3 + 4 (n = 31) than in PC with GS = 6 (n = 14) (P = 0.008). Conclusion Qualitative DCE-MRI indices may contribute to PC aggressiveness and improve detection of csPC in PI-RADS assessment category 3 lesions.https://doi.org/10.1007/s12672-024-01668-9Prostate cancerTumor aggressivenessMRIDynamic contrast-enhanced MRIPI-RADS |
| spellingShingle | Tsutomu Tamada Mitsuru Takeuchi Hiroyuki Watanabe Atsushi Higaki Kazunori Moriya Akihiko Kanki Yoshihiko Fukukura Akira Yamamoto Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRI Discover Oncology Prostate cancer Tumor aggressiveness MRI Dynamic contrast-enhanced MRI PI-RADS |
| title | Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRI |
| title_full | Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRI |
| title_fullStr | Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRI |
| title_full_unstemmed | Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRI |
| title_short | Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRI |
| title_sort | differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi quantitative indices of dynamic contrast enhanced mri |
| topic | Prostate cancer Tumor aggressiveness MRI Dynamic contrast-enhanced MRI PI-RADS |
| url | https://doi.org/10.1007/s12672-024-01668-9 |
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