Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale
In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/484979 |
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| _version_ | 1849412833469530112 |
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| author | Alessio Rungatscher Maddalena Tessari Chiara Stranieri Erika Solani Daniele Linardi Elisabetta Milani Alessio Montresor Flavia Merigo Beatrice Salvetti Tiziano Menon Giuseppe Faggian |
| author_facet | Alessio Rungatscher Maddalena Tessari Chiara Stranieri Erika Solani Daniele Linardi Elisabetta Milani Alessio Montresor Flavia Merigo Beatrice Salvetti Tiziano Menon Giuseppe Faggian |
| author_sort | Alessio Rungatscher |
| collection | DOAJ |
| description | In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction. The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics. |
| format | Article |
| id | doaj-art-4cf2ce8b51cd4865afa18e68c5f42293 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4cf2ce8b51cd4865afa18e68c5f422932025-08-20T03:34:20ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/484979484979Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary TaleAlessio Rungatscher0Maddalena Tessari1Chiara Stranieri2Erika Solani3Daniele Linardi4Elisabetta Milani5Alessio Montresor6Flavia Merigo7Beatrice Salvetti8Tiziano Menon9Giuseppe Faggian10Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, ItalyDepartment of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, ItalySection of General Pathology, Department of Pathology and Diagnostics, University of Verona, 37126 Verona, ItalySection of General Pathology, Department of Pathology and Diagnostics, University of Verona, 37126 Verona, ItalyDepartment of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, ItalyDepartment of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, ItalySection of General Pathology, Department of Pathology and Diagnostics, University of Verona, 37126 Verona, ItalyDepartment of Neurological and Movement Sciences, University of Verona, 37126 Verona, ItalyDepartment of Neurological and Movement Sciences, University of Verona, 37126 Verona, ItalyDepartment of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, ItalyDepartment of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, ItalyIn order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction. The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics.http://dx.doi.org/10.1155/2015/484979 |
| spellingShingle | Alessio Rungatscher Maddalena Tessari Chiara Stranieri Erika Solani Daniele Linardi Elisabetta Milani Alessio Montresor Flavia Merigo Beatrice Salvetti Tiziano Menon Giuseppe Faggian Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale Mediators of Inflammation |
| title | Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale |
| title_full | Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale |
| title_fullStr | Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale |
| title_full_unstemmed | Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale |
| title_short | Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale |
| title_sort | oxygenator is the main responsible for leukocyte activation in experimental model of extracorporeal circulation a cautionary tale |
| url | http://dx.doi.org/10.1155/2015/484979 |
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