Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination
A next-generation STING agonist MSA-2 is a promising tumor immunotherapy strategy. However, the methods for improving the anti-tumor efficacy of MSA-2 are a lot of effort. We have demonstrated antitumor effect of platinum-modified MSA-2 (MSA-2-Pt) was better than MSA-2. Here, we combined lipid nanop...
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000043 |
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| author | Tian He Yating Li Weiqi Li Muqing Zhang Guishuan Wang Peng Zhou Guoqi Song Wenqing Li |
| author_facet | Tian He Yating Li Weiqi Li Muqing Zhang Guishuan Wang Peng Zhou Guoqi Song Wenqing Li |
| author_sort | Tian He |
| collection | DOAJ |
| description | A next-generation STING agonist MSA-2 is a promising tumor immunotherapy strategy. However, the methods for improving the anti-tumor efficacy of MSA-2 are a lot of effort. We have demonstrated antitumor effect of platinum-modified MSA-2 (MSA-2-Pt) was better than MSA-2. Here, we combined lipid nanoparticles delivering circular IL-23 mRNA (LNP@cIL-23) and MSA-2-Pt strategy, which showed good antitumor efficacy. Firstly, we synthesized a new series of ionizable phospholipids and formulated and optimized an LNP36 for delivering circular IL-23 mRNA. Then, the combination of LNP36@cIL-23 mRNA and MSA-2-Pt induced tumor cell death and immune activation in the tumor with a single i.t. injection. Finally, the combination of LNP36@cIL-23 mRNA and MSA-2-Pt significantly decreased the melanoma B16F10 tumor and prolonged the survival, demonstrating significant anti-tumor effects. This finding provides promising new avenues for STING activation strategies in tumor immunotherapy. |
| format | Article |
| id | doaj-art-4cf1d8e4a5524ab9b324f65f69199c69 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-4cf1d8e4a5524ab9b324f65f69199c692025-01-17T04:52:16ZengElsevierMaterials Today Bio2590-00642025-02-0130101446Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combinationTian He0Yating Li1Weiqi Li2Muqing Zhang3Guishuan Wang4Peng Zhou5Guoqi Song6Wenqing Li7Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, Jiangsu, 226000, ChinaInstitute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, Jiangsu, 226000, ChinaInstitute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, Jiangsu, 226000, ChinaInstitute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, Jiangsu, 226000, ChinaInstitute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, Jiangsu, 226000, China; Corresponding author.Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, Jiangsu, 226000, China; Corresponding authors.Department of Hematology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, 226000, China; Corresponding author.Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, Jiangsu, 226000, China; Corresponding authors.A next-generation STING agonist MSA-2 is a promising tumor immunotherapy strategy. However, the methods for improving the anti-tumor efficacy of MSA-2 are a lot of effort. We have demonstrated antitumor effect of platinum-modified MSA-2 (MSA-2-Pt) was better than MSA-2. Here, we combined lipid nanoparticles delivering circular IL-23 mRNA (LNP@cIL-23) and MSA-2-Pt strategy, which showed good antitumor efficacy. Firstly, we synthesized a new series of ionizable phospholipids and formulated and optimized an LNP36 for delivering circular IL-23 mRNA. Then, the combination of LNP36@cIL-23 mRNA and MSA-2-Pt induced tumor cell death and immune activation in the tumor with a single i.t. injection. Finally, the combination of LNP36@cIL-23 mRNA and MSA-2-Pt significantly decreased the melanoma B16F10 tumor and prolonged the survival, demonstrating significant anti-tumor effects. This finding provides promising new avenues for STING activation strategies in tumor immunotherapy.http://www.sciencedirect.com/science/article/pii/S2590006425000043STING agonistMSA-2Lipid nanoparticlesCircular IL-23 mRNAPlatinum-modified MSA-2 (MSA-2-Pt) |
| spellingShingle | Tian He Yating Li Weiqi Li Muqing Zhang Guishuan Wang Peng Zhou Guoqi Song Wenqing Li Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination Materials Today Bio STING agonist MSA-2 Lipid nanoparticles Circular IL-23 mRNA Platinum-modified MSA-2 (MSA-2-Pt) |
| title | Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination |
| title_full | Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination |
| title_fullStr | Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination |
| title_full_unstemmed | Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination |
| title_short | Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination |
| title_sort | enhanced antitumor efficacy of sting agonist msa 2 by lipid nanoparticles delivering circular il 23 mrna and platinum modified msa 2 combination |
| topic | STING agonist MSA-2 Lipid nanoparticles Circular IL-23 mRNA Platinum-modified MSA-2 (MSA-2-Pt) |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000043 |
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