The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds
Chronic refractory wounds (CRWs) represent a common and challenging issue in clinical practice, including diabetic foot ulcers, pressure ulcers, venous ulcers, and arterial ulcers. These wounds significantly impact patients' quality of life and may lead to severe consequences such as amputation...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825001781 |
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| author | Fengdan Xu Qiling Zhang Yuling Liu Ruying Tang Hui Li Hongjun Yang Longfei Lin |
| author_facet | Fengdan Xu Qiling Zhang Yuling Liu Ruying Tang Hui Li Hongjun Yang Longfei Lin |
| author_sort | Fengdan Xu |
| collection | DOAJ |
| description | Chronic refractory wounds (CRWs) represent a common and challenging issue in clinical practice, including diabetic foot ulcers, pressure ulcers, venous ulcers, and arterial ulcers. These wounds significantly impact patients' quality of life and may lead to severe consequences such as amputation. Their treatment requires a comprehensive consideration of both the patient's overall physical condition and the local wound situation. The major challenges in treatment include complex pathogenesis, a long treatment cycle, a high recurrence rate, and heavy economic pressure on the patients. Exosomes represent an emerging therapeutic modality with characteristics such as low immunogenicity, good biostability, and high targeting efficiency in the treatment of diseases. Exosomes derived from different sources exhibit heterogeneity, demonstrating their respective advantages and unique properties in treatment. This article delves into the potential applications and mechanisms of action of exosomes from various sources in the treatment of CRWs, aiming to provide new perspectives and ideas for the management of such wounds. |
| format | Article |
| id | doaj-art-4cf095f477494bcc98016acf577ccff8 |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-4cf095f477494bcc98016acf577ccff82025-08-20T02:32:19ZengElsevierPharmacological Research1096-11862025-06-0121610775310.1016/j.phrs.2025.107753The role of exosomes derived from various sources in facilitating the healing of chronic refractory woundsFengdan Xu0Qiling Zhang1Yuling Liu2Ruying Tang3Hui Li4Hongjun Yang5Longfei Lin6State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang 330000, China; Correspondence to: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.China Academy of Chinese Medical Sciences, Beijing 100700, China; Correspondence to: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Correspondence to: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Chronic refractory wounds (CRWs) represent a common and challenging issue in clinical practice, including diabetic foot ulcers, pressure ulcers, venous ulcers, and arterial ulcers. These wounds significantly impact patients' quality of life and may lead to severe consequences such as amputation. Their treatment requires a comprehensive consideration of both the patient's overall physical condition and the local wound situation. The major challenges in treatment include complex pathogenesis, a long treatment cycle, a high recurrence rate, and heavy economic pressure on the patients. Exosomes represent an emerging therapeutic modality with characteristics such as low immunogenicity, good biostability, and high targeting efficiency in the treatment of diseases. Exosomes derived from different sources exhibit heterogeneity, demonstrating their respective advantages and unique properties in treatment. This article delves into the potential applications and mechanisms of action of exosomes from various sources in the treatment of CRWs, aiming to provide new perspectives and ideas for the management of such wounds.http://www.sciencedirect.com/science/article/pii/S1043661825001781ExosomesChronic refractory woundsApplication prospectsWound healingDiabetic foot ulcers |
| spellingShingle | Fengdan Xu Qiling Zhang Yuling Liu Ruying Tang Hui Li Hongjun Yang Longfei Lin The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds Pharmacological Research Exosomes Chronic refractory wounds Application prospects Wound healing Diabetic foot ulcers |
| title | The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds |
| title_full | The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds |
| title_fullStr | The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds |
| title_full_unstemmed | The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds |
| title_short | The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds |
| title_sort | role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds |
| topic | Exosomes Chronic refractory wounds Application prospects Wound healing Diabetic foot ulcers |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825001781 |
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