NAT10 promotes hepatocellular carcinoma progression by modulating the ac4C-DDIAS-PI3K-Akt axis

NAT10 promotes hepatocellular carcinoma progression by modulating the ac4C-DDIAS-PI3K-Akt axis

Abstract Primary liver cancer (PLC) is a prevalent tumor globally, ranking third in cancer-related mortality. The role of N4-acetylcysteine (ac4C) and N-acetyltransferase 10 (NAT10) in hepatocellular carcinoma (HCC) progression, migration, and invasion requires further elucidation. High NAT10 expres...

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Bibliographic Details
Main Authors: Yue Tao, Leisheng Wang, Enhong Chen, Shuo Zhang, Dongjie Yang, Wuqiang Chen, Youzhao He, Yuanlong Gu, Yong Mao, Hao Hu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Hepatocellular carcinoma
NAT10
Acetylation
ac4C
DDIAS
PI3K-AKT
Online Access:https://doi.org/10.1038/s41598-025-00707-x
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