Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women
Interleukin-17 (IL-17) is a proinflammatory cytokine that is associated with inflammation, autoimmune disorders, and even tumors. Previous studies revealed that a large group of human malignant tumors have abnormally high IL-17 expression. In the present study, we analyzed two single-nucleotide poly...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/258293 |
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| author | Yi Quan Bin Zhou Yanyun Wang Ruiqi Duan Kana Wang Qianqian Gao Shaoqing Shi Yaping Song Lin Zhang Mingrong Xi |
| author_facet | Yi Quan Bin Zhou Yanyun Wang Ruiqi Duan Kana Wang Qianqian Gao Shaoqing Shi Yaping Song Lin Zhang Mingrong Xi |
| author_sort | Yi Quan |
| collection | DOAJ |
| description | Interleukin-17 (IL-17) is a proinflammatory cytokine that is associated with inflammation, autoimmune disorders, and even tumors. Previous studies revealed that a large group of human malignant tumors have abnormally high IL-17 expression. In the present study, we analyzed two single-nucleotide polymorphisms (SNPs) in the IL17A (rs2275913) and IL17F (rs763780) in 311 cervical cancer patients and 463 controls using TaqMan assays. Our results indicated that the frequencies of AA genotype and A allele of rs2275913 were significantly different between the cervical cancer patients and controls (P=0.008, OR = 1.32, 95% CI, 1.07–1.62). Stratified analyses revealed that the polymorphism of rs2275913 was also associated with positive peritumor intravascular cancer emboli and high clinical stage. The genotype and allele frequencies of rs763780 did not show any difference between patients and controls or relate to patient clinical characteristics. Collectively, these findings suggested that IL17 gene polymorphism rs2275913 was associated with the susceptibility as well as positive peritumor intravascular cancer emboli and high clinical stage of cervical cancer in Chinese women. |
| format | Article |
| id | doaj-art-4cead69bd02445c6887a81895cdf82cd |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-4cead69bd02445c6887a81895cdf82cd2025-08-20T02:38:36ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/258293258293Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese WomenYi Quan0Bin Zhou1Yanyun Wang2Ruiqi Duan3Kana Wang4Qianqian Gao5Shaoqing Shi6Yaping Song7Lin Zhang8Mingrong Xi9Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaLaboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaLaboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaLaboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaLaboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaLaboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, ChinaInterleukin-17 (IL-17) is a proinflammatory cytokine that is associated with inflammation, autoimmune disorders, and even tumors. Previous studies revealed that a large group of human malignant tumors have abnormally high IL-17 expression. In the present study, we analyzed two single-nucleotide polymorphisms (SNPs) in the IL17A (rs2275913) and IL17F (rs763780) in 311 cervical cancer patients and 463 controls using TaqMan assays. Our results indicated that the frequencies of AA genotype and A allele of rs2275913 were significantly different between the cervical cancer patients and controls (P=0.008, OR = 1.32, 95% CI, 1.07–1.62). Stratified analyses revealed that the polymorphism of rs2275913 was also associated with positive peritumor intravascular cancer emboli and high clinical stage. The genotype and allele frequencies of rs763780 did not show any difference between patients and controls or relate to patient clinical characteristics. Collectively, these findings suggested that IL17 gene polymorphism rs2275913 was associated with the susceptibility as well as positive peritumor intravascular cancer emboli and high clinical stage of cervical cancer in Chinese women.http://dx.doi.org/10.1155/2012/258293 |
| spellingShingle | Yi Quan Bin Zhou Yanyun Wang Ruiqi Duan Kana Wang Qianqian Gao Shaoqing Shi Yaping Song Lin Zhang Mingrong Xi Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women Clinical and Developmental Immunology |
| title | Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women |
| title_full | Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women |
| title_fullStr | Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women |
| title_full_unstemmed | Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women |
| title_short | Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women |
| title_sort | association between il17 polymorphisms and risk of cervical cancer in chinese women |
| url | http://dx.doi.org/10.1155/2012/258293 |
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