Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment
Aging is a general biological process inherent in all living organisms. It is characterized by progressive cellular dysfunction. For many years, aging has been widely recognized as a highly effective mechanism for suppressing the progression of malignant neoplasms. However, in recent years, increasi...
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MDPI AG
2025-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/2/199 |
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| author | Yulia Aleksandrova Margarita Neganova |
| author_facet | Yulia Aleksandrova Margarita Neganova |
| author_sort | Yulia Aleksandrova |
| collection | DOAJ |
| description | Aging is a general biological process inherent in all living organisms. It is characterized by progressive cellular dysfunction. For many years, aging has been widely recognized as a highly effective mechanism for suppressing the progression of malignant neoplasms. However, in recent years, increasing evidence suggests a “double-edged” role of aging in cancer development. According to these data, aging is not only a tumor suppressor that leads to cell cycle arrest in neoplastic cells, but also a cancer promoter that ensures a chronic proinflammatory and immunosuppressive microenvironment. In this regard, in our review, we discuss recent data on the destructive role of senescent cells in the pathogenesis of cancer. We also identify for the first time correlations between the modulation of the senescence-associated secretory phenotype and the antitumor effects of naturally occurring molecules. |
| format | Article |
| id | doaj-art-4ce6fd76550f40a28d2e95a1eeb527ca |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-4ce6fd76550f40a28d2e95a1eeb527ca2025-08-20T02:44:40ZengMDPI AGAntioxidants2076-39212025-02-0114219910.3390/antiox14020199Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer TreatmentYulia Aleksandrova0Margarita Neganova1Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, RussiaNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, RussiaAging is a general biological process inherent in all living organisms. It is characterized by progressive cellular dysfunction. For many years, aging has been widely recognized as a highly effective mechanism for suppressing the progression of malignant neoplasms. However, in recent years, increasing evidence suggests a “double-edged” role of aging in cancer development. According to these data, aging is not only a tumor suppressor that leads to cell cycle arrest in neoplastic cells, but also a cancer promoter that ensures a chronic proinflammatory and immunosuppressive microenvironment. In this regard, in our review, we discuss recent data on the destructive role of senescent cells in the pathogenesis of cancer. We also identify for the first time correlations between the modulation of the senescence-associated secretory phenotype and the antitumor effects of naturally occurring molecules.https://www.mdpi.com/2076-3921/14/2/199senescent cellscellular senescencesenescence-associated secretory phenotypesenotherapysenolytic agentsantioxidant drugs |
| spellingShingle | Yulia Aleksandrova Margarita Neganova Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment Antioxidants senescent cells cellular senescence senescence-associated secretory phenotype senotherapy senolytic agents antioxidant drugs |
| title | Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment |
| title_full | Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment |
| title_fullStr | Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment |
| title_full_unstemmed | Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment |
| title_short | Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment |
| title_sort | antioxidant senotherapy by natural compounds a beneficial partner in cancer treatment |
| topic | senescent cells cellular senescence senescence-associated secretory phenotype senotherapy senolytic agents antioxidant drugs |
| url | https://www.mdpi.com/2076-3921/14/2/199 |
| work_keys_str_mv | AT yuliaaleksandrova antioxidantsenotherapybynaturalcompoundsabeneficialpartnerincancertreatment AT margaritaneganova antioxidantsenotherapybynaturalcompoundsabeneficialpartnerincancertreatment |