Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes
Background. Regulatory T (Treg) cells play a protective role in atherosclerosis prone models and are related to the onset of acute coronary syndromes (ACS, including non-ST-elevation ACS (NSTEACS) and ST-elevation acute myocardial infarction (STEAMI)). CD4+LAP+ Treg cells are a novel subset of Tregs...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/764082 |
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| _version_ | 1832561908930052096 |
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| author | Ying-zhong Lin Shan-he Lu Zheng-de Lu Ying Huang Ying Shi Ling Liu Xiao-yan Wang Qing-wei Ji |
| author_facet | Ying-zhong Lin Shan-he Lu Zheng-de Lu Ying Huang Ying Shi Ling Liu Xiao-yan Wang Qing-wei Ji |
| author_sort | Ying-zhong Lin |
| collection | DOAJ |
| description | Background. Regulatory T (Treg) cells play a protective role in atherosclerosis prone models and are related to the onset of acute coronary syndromes (ACS, including non-ST-elevation ACS (NSTEACS) and ST-elevation acute myocardial infarction (STEAMI)). CD4+LAP+ Treg cells are a novel subset of Tregs that have been found to ameliorate atherosclerosis in ApoE-/- mice, and these cells also exist in humans. The present study was designed to investigate whether CD4+LAP+ Treg cells are involved in the onset of ACS. Methods. The frequencies of CD4+LAP+ and CD4+CD25+ Treg cells were detected using flow cytometric analysis, and the plasma IL-10 and TGF-β1 levels were measured using an ELISA in 29 stable angina (SA) patients, 30 NSTEACS patients, 27 STEAMI patients, and a control group (30 cases).
Results. The results revealed a significant decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells and in the levels of IL-10 and TGF-β1 in patients with ACS compared with those in the SA and control groups. Conclusions. The decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells may play a role in the onset of ACS. |
| format | Article |
| id | doaj-art-4ce57ffa82a84d129f927bc6f3669af5 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4ce57ffa82a84d129f927bc6f3669af52025-02-03T01:23:49ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/764082764082Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary SyndromesYing-zhong Lin0Shan-he Lu1Zheng-de Lu2Ying Huang3Ying Shi4Ling Liu5Xiao-yan Wang6Qing-wei Ji7Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Ultrasound, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Ultrasound, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaBackground. Regulatory T (Treg) cells play a protective role in atherosclerosis prone models and are related to the onset of acute coronary syndromes (ACS, including non-ST-elevation ACS (NSTEACS) and ST-elevation acute myocardial infarction (STEAMI)). CD4+LAP+ Treg cells are a novel subset of Tregs that have been found to ameliorate atherosclerosis in ApoE-/- mice, and these cells also exist in humans. The present study was designed to investigate whether CD4+LAP+ Treg cells are involved in the onset of ACS. Methods. The frequencies of CD4+LAP+ and CD4+CD25+ Treg cells were detected using flow cytometric analysis, and the plasma IL-10 and TGF-β1 levels were measured using an ELISA in 29 stable angina (SA) patients, 30 NSTEACS patients, 27 STEAMI patients, and a control group (30 cases). Results. The results revealed a significant decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells and in the levels of IL-10 and TGF-β1 in patients with ACS compared with those in the SA and control groups. Conclusions. The decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells may play a role in the onset of ACS.http://dx.doi.org/10.1155/2013/764082 |
| spellingShingle | Ying-zhong Lin Shan-he Lu Zheng-de Lu Ying Huang Ying Shi Ling Liu Xiao-yan Wang Qing-wei Ji Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes Mediators of Inflammation |
| title | Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes |
| title_full | Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes |
| title_fullStr | Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes |
| title_full_unstemmed | Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes |
| title_short | Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes |
| title_sort | downregulation of cd4 lap and cd4 cd25 regulatory t cells in acute coronary syndromes |
| url | http://dx.doi.org/10.1155/2013/764082 |
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