THE ROLE OF MICROBIOTA IN CELLULAR HOMEOSTASIS AND MUTAGENESIS
The human body is currently considered as a meta-organism, evolutionarily inhabited by numerous microbes which populations evolve and adapt according to the changing conditions. The advent of high-throughput genomic and metabolomic approaches uncovered the complexity of interactions between the host...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2018-12-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/121 |
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| author | VLADIMIR G. Druzhinin VLADISLAV YU. Buslaev ELIZAVETA D. Baranova LYUBOV V. Nacheva |
| author_facet | VLADIMIR G. Druzhinin VLADISLAV YU. Buslaev ELIZAVETA D. Baranova LYUBOV V. Nacheva |
| author_sort | VLADIMIR G. Druzhinin |
| collection | DOAJ |
| description | The human body is currently considered as a meta-organism, evolutionarily inhabited by numerous microbes which populations evolve and adapt according to the changing conditions. The advent of high-throughput genomic and metabolomic approaches uncovered the complexity of interactions between the host and its microbiota, primarily mediated by synthesis of microbial bioactive compounds including mutagens. Alter-ations in microenvironment may disturb homeostasis of microbiota leading to the increased production of hazardous metabolites that, in turn, may initiate or promote disease development. Here we evaluate existing data on the role of human microbiota in physiological and pathological processes, with a particular focus on metabolomics. |
| format | Article |
| id | doaj-art-4ce122caa2724424ae9fe6e0a2bfa58f |
| institution | Kabale University |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2018-12-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-4ce122caa2724424ae9fe6e0a2bfa58f2025-08-20T03:57:40ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412018-12-01348392120THE ROLE OF MICROBIOTA IN CELLULAR HOMEOSTASIS AND MUTAGENESISVLADIMIR G. Druzhinin0VLADISLAV YU. Buslaev1ELIZAVETA D. Baranova2LYUBOV V. Nacheva3Kemerovo State UniversityKemerovo State UniversityKemerovo State UniversityKemerovo State Medical UniversityThe human body is currently considered as a meta-organism, evolutionarily inhabited by numerous microbes which populations evolve and adapt according to the changing conditions. The advent of high-throughput genomic and metabolomic approaches uncovered the complexity of interactions between the host and its microbiota, primarily mediated by synthesis of microbial bioactive compounds including mutagens. Alter-ations in microenvironment may disturb homeostasis of microbiota leading to the increased production of hazardous metabolites that, in turn, may initiate or promote disease development. Here we evaluate existing data on the role of human microbiota in physiological and pathological processes, with a particular focus on metabolomics.https://fcm.kemsmu.ru/jour/article/view/121микробиотагенотоксичностьмутагенезканцерогенезгомеостазmicrobiotagenotoxicitymutagenesiscarcinogenesishomeostasis |
| spellingShingle | VLADIMIR G. Druzhinin VLADISLAV YU. Buslaev ELIZAVETA D. Baranova LYUBOV V. Nacheva THE ROLE OF MICROBIOTA IN CELLULAR HOMEOSTASIS AND MUTAGENESIS Фундаментальная и клиническая медицина микробиота генотоксичность мутагенез канцерогенез гомеостаз microbiota genotoxicity mutagenesis carcinogenesis homeostasis |
| title | THE ROLE OF MICROBIOTA IN CELLULAR HOMEOSTASIS AND MUTAGENESIS |
| title_full | THE ROLE OF MICROBIOTA IN CELLULAR HOMEOSTASIS AND MUTAGENESIS |
| title_fullStr | THE ROLE OF MICROBIOTA IN CELLULAR HOMEOSTASIS AND MUTAGENESIS |
| title_full_unstemmed | THE ROLE OF MICROBIOTA IN CELLULAR HOMEOSTASIS AND MUTAGENESIS |
| title_short | THE ROLE OF MICROBIOTA IN CELLULAR HOMEOSTASIS AND MUTAGENESIS |
| title_sort | role of microbiota in cellular homeostasis and mutagenesis |
| topic | микробиота генотоксичность мутагенез канцерогенез гомеостаз microbiota genotoxicity mutagenesis carcinogenesis homeostasis |
| url | https://fcm.kemsmu.ru/jour/article/view/121 |
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