Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation
Apical constriction is a basic mechanism for epithelial morphogenesis, making columnar cells into wedge shape and bending a flat cell sheet. It has long been thought that an apically localized myosin generates a contractile force and drives the cell deformation. However, when we tested the increased...
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| Format: | Article |
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eLife Sciences Publications Ltd
2025-04-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/93496 |
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| author | Satoshi Yamashita Shuji Ishihara François Graner |
| author_facet | Satoshi Yamashita Shuji Ishihara François Graner |
| author_sort | Satoshi Yamashita |
| collection | DOAJ |
| description | Apical constriction is a basic mechanism for epithelial morphogenesis, making columnar cells into wedge shape and bending a flat cell sheet. It has long been thought that an apically localized myosin generates a contractile force and drives the cell deformation. However, when we tested the increased apical surface contractility in a cellular Potts model simulation, the constriction increased pressure inside the cell and pushed its lateral surface outward, making the cells adopt a drop shape instead of the expected wedge shape. To keep the lateral surface straight, we considered an alternative model in which the cell shape was determined by cell membrane elasticity and endocytosis, and the increased pressure is balanced among the cells. The cellular Potts model simulation succeeded in reproducing the apical constriction, and it also suggested that a too strong apical surface tension might prevent the tissue invagination. |
| format | Article |
| id | doaj-art-4cdc7ecfbb2c447ca9946b536108cb67 |
| institution | DOAJ |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-4cdc7ecfbb2c447ca9946b536108cb672025-08-20T03:18:05ZengeLife Sciences Publications LtdeLife2050-084X2025-04-011310.7554/eLife.93496Apical constriction requires patterned apical surface remodeling to synchronize cellular deformationSatoshi Yamashita0https://orcid.org/0000-0002-1271-4911Shuji Ishihara1François Graner2Laboratory for Morphogenetic Signaling, RIKEN Center for Biosystems Dynamics Research, Kobe, JapanGraduate School of Arts and Sciences, The University of Tokyo, Tokyo, JapanUniversité Paris Cité, CNRS, MSC, Paris, FranceApical constriction is a basic mechanism for epithelial morphogenesis, making columnar cells into wedge shape and bending a flat cell sheet. It has long been thought that an apically localized myosin generates a contractile force and drives the cell deformation. However, when we tested the increased apical surface contractility in a cellular Potts model simulation, the constriction increased pressure inside the cell and pushed its lateral surface outward, making the cells adopt a drop shape instead of the expected wedge shape. To keep the lateral surface straight, we considered an alternative model in which the cell shape was determined by cell membrane elasticity and endocytosis, and the increased pressure is balanced among the cells. The cellular Potts model simulation succeeded in reproducing the apical constriction, and it also suggested that a too strong apical surface tension might prevent the tissue invagination.https://elifesciences.org/articles/93496apical constrictionsimulationcellular Potts model |
| spellingShingle | Satoshi Yamashita Shuji Ishihara François Graner Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation eLife apical constriction simulation cellular Potts model |
| title | Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation |
| title_full | Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation |
| title_fullStr | Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation |
| title_full_unstemmed | Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation |
| title_short | Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation |
| title_sort | apical constriction requires patterned apical surface remodeling to synchronize cellular deformation |
| topic | apical constriction simulation cellular Potts model |
| url | https://elifesciences.org/articles/93496 |
| work_keys_str_mv | AT satoshiyamashita apicalconstrictionrequirespatternedapicalsurfaceremodelingtosynchronizecellulardeformation AT shujiishihara apicalconstrictionrequirespatternedapicalsurfaceremodelingtosynchronizecellulardeformation AT francoisgraner apicalconstrictionrequirespatternedapicalsurfaceremodelingtosynchronizecellulardeformation |