The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients
Objective. In this study, we aimed to investigate the possible role of serum cytokines in the development of hepatic osteodystrophy. Matherial and Methods. 44 consecutive male cirrhotic patients (17 alcoholic, 20 hepatitis B, 7 hepatitis C), 15 age- and sex-matched chronic alcoholics without liver d...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/425079 |
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| author | Ali Riza Soylu Cengiz Tuglu Ender Arikan Tarkan Yetisyigit Hakan Kunduracılar Ibrahim Hakki Koker Gulbin Unsal Ahmet Huseyin Tezel Hasan Umit Sakir Berkarda |
| author_facet | Ali Riza Soylu Cengiz Tuglu Ender Arikan Tarkan Yetisyigit Hakan Kunduracılar Ibrahim Hakki Koker Gulbin Unsal Ahmet Huseyin Tezel Hasan Umit Sakir Berkarda |
| author_sort | Ali Riza Soylu |
| collection | DOAJ |
| description | Objective. In this study, we aimed to investigate the possible role of serum cytokines in the development of hepatic osteodystrophy. Matherial and Methods. 44 consecutive male cirrhotic patients (17 alcoholic, 20 hepatitis B, 7 hepatitis C), 15 age- and sex-matched chronic alcoholics without liver disease, and 17 age- and sex-matched healthy controls were included in the study during one year period. Bone mineral density was measured by dual X-ray absorptiometry in the lumbar vertebrate and femoral neck. Serum interleukin levels were measured by ELISA method. Results. Although osteopenia frequency between our cirrhotic patients was 20%, there was no difference in T-scores among the controls and other groups. Serum interleukin-1, interleukin-8, and tumor necrosis factor-alpha levels were not different between all groups. Serum interleukin-2 and interleukin-6 levels were higher in the cirrhotics than controls (P<0.001). However, there were no significant difference between osteopenic and nonosteopenic cirrhotics. Conclusion. According to the results of the study in this small population of 44 male cirrhotic patients, frequency of hepatic osteopenia is small and serum interleukins 1, 2, 6, 8, and tumor necrosis factor-alpha may not play a role in the pathogenesis of hepatic osteodystrophy. Further studies in which large number of patients involved are necessary in this field. |
| format | Article |
| id | doaj-art-4cda562250f443ae9625a2ea3167a12b |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-4cda562250f443ae9625a2ea3167a12b2025-02-03T06:01:22ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/425079425079The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic PatientsAli Riza Soylu0Cengiz Tuglu1Ender Arikan2Tarkan Yetisyigit3Hakan Kunduracılar4Ibrahim Hakki Koker5Gulbin Unsal6Ahmet Huseyin Tezel7Hasan Umit8Sakir Berkarda9Department of Gastroenterology, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Psychiatry, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Endocrinology and Metabolism, Faculty of Medicine, Acıbadem University, 34848 Istanbul, TurkeyDepartment of Oncology, Ankara Oncology Hospital, 06200 Ankara, TurkeyHealth Services Vocational School, Trakya University, 22030 Edirne, TurkeyDepartment of Gastroenterology, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Gastroenterology, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Gastroenterology, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Gastroenterology, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Nuclear Medicine, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyObjective. In this study, we aimed to investigate the possible role of serum cytokines in the development of hepatic osteodystrophy. Matherial and Methods. 44 consecutive male cirrhotic patients (17 alcoholic, 20 hepatitis B, 7 hepatitis C), 15 age- and sex-matched chronic alcoholics without liver disease, and 17 age- and sex-matched healthy controls were included in the study during one year period. Bone mineral density was measured by dual X-ray absorptiometry in the lumbar vertebrate and femoral neck. Serum interleukin levels were measured by ELISA method. Results. Although osteopenia frequency between our cirrhotic patients was 20%, there was no difference in T-scores among the controls and other groups. Serum interleukin-1, interleukin-8, and tumor necrosis factor-alpha levels were not different between all groups. Serum interleukin-2 and interleukin-6 levels were higher in the cirrhotics than controls (P<0.001). However, there were no significant difference between osteopenic and nonosteopenic cirrhotics. Conclusion. According to the results of the study in this small population of 44 male cirrhotic patients, frequency of hepatic osteopenia is small and serum interleukins 1, 2, 6, 8, and tumor necrosis factor-alpha may not play a role in the pathogenesis of hepatic osteodystrophy. Further studies in which large number of patients involved are necessary in this field.http://dx.doi.org/10.1155/2012/425079 |
| spellingShingle | Ali Riza Soylu Cengiz Tuglu Ender Arikan Tarkan Yetisyigit Hakan Kunduracılar Ibrahim Hakki Koker Gulbin Unsal Ahmet Huseyin Tezel Hasan Umit Sakir Berkarda The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients Gastroenterology Research and Practice |
| title | The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients |
| title_full | The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients |
| title_fullStr | The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients |
| title_full_unstemmed | The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients |
| title_short | The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients |
| title_sort | role of serum cytokines in the pathogenesis of hepatic osteodystrophy in male cirrhotic patients |
| url | http://dx.doi.org/10.1155/2012/425079 |
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