Infiltration of local anesthetics into the surgical wound: effect on inflammation and fibrous scar in rats
Introduction: Pain relief after surgery remains one of the most significant medical challenges, mainly in aesthetic surgery. The infiltration of the surgical incision with local anesthetics has been increasingly used to reduce pain and other analgesic use. However, little is known about the effect o...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações Ltda.
2023-08-01
|
| Series: | Revista Brasileira de Cirurgia Plástica |
| Subjects: | |
| Online Access: | http://www.rbcp.org.br/export-pdf/3027/en_v36n4a09.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849246798950957056 |
|---|---|
| author | Maida Silva Calçado Élia Cláudia De Souza Almeida Luciano Alves Matias Silveira Gizele Costa Oliveira Ana Carolina Gonçalves Beatriz Junqueira Mattar Renata Margarida Etchebehere |
| author_facet | Maida Silva Calçado Élia Cláudia De Souza Almeida Luciano Alves Matias Silveira Gizele Costa Oliveira Ana Carolina Gonçalves Beatriz Junqueira Mattar Renata Margarida Etchebehere |
| author_sort | Maida Silva Calçado |
| collection | DOAJ |
| description | Introduction: Pain relief after surgery remains one of the most significant medical challenges, mainly in aesthetic surgery. The infiltration of the surgical incision with local anesthetics has been increasingly used to reduce pain and other analgesic use. However, little is known about the effect of this injection on healing. The objective is to evaluate the interference of local anesthetics in the area of inflammatory infiltrate and fibrosis scar in rats.
Methods: Two linear incisions each were made on the dorsal region of 40 Wistar rats. The left incision was infiltrated with doses of 1.8ml of bupivacaine, levobupivacaine, ropivacaine, or 0,9% saline solution infiltration. The right incision did not receive infiltration, serving as a control group. After seven days, samples of the incisions were collected for histological morphometric evaluation.
Results: When compared with the control groups, the area of inflammatory infiltrate was found larger in the bupivacaine, ropivacaine, and levobupivacaine groups. The bupivacaine group presented a larger inflammatory infiltrate than the levobupivacaine and ropivacaine. The fibrous scar area was larger in the levobupivacaine and ropivacaine groups. There was no difference between the groups that received anesthetic and saline solution.
Conclusion: As there was no difference between the anesthetics and saline solution groups, the volume applied, or the trauma may have been the cause of the larger areas of infiltrating and scar associated with local anesthetics application. |
| format | Article |
| id | doaj-art-4cd9648aeaaf40caa0148eb00ffb0ecc |
| institution | Kabale University |
| issn | 1983-5175 2177-1235 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Revista Brasileira de Cirurgia Plástica |
| spelling | doaj-art-4cd9648aeaaf40caa0148eb00ffb0ecc2025-08-20T03:58:23ZengThieme Revinter Publicações Ltda.Revista Brasileira de Cirurgia Plástica1983-51752177-12352023-08-01360443143610.5935/2177-1235.2021RBCP0128Infiltration of local anesthetics into the surgical wound: effect on inflammation and fibrous scar in ratsMaida Silva Calçado0Élia Cláudia De Souza Almeida1Luciano Alves Matias Silveira2Gizele Costa Oliveira3Ana Carolina Gonçalves4Beatriz Junqueira Mattar5Renata Margarida Etchebehere6Federal University of Triângulo Mineiro, Uberaba, MG, BrazilFederal University of Triângulo Mineiro, Uberaba, MG, BrazilFederal University of Triângulo Mineiro, Uberaba, MG, BrazilFederal University of Triângulo Mineiro, Uberaba, MG, BrazilFederal University of Triângulo Mineiro, Uberaba, MG, BrazilUniversity of Uberaba, Uberaba, MG, BrazilFederal University of Triângulo Mineiro, Uberaba, MG, BrazilIntroduction: Pain relief after surgery remains one of the most significant medical challenges, mainly in aesthetic surgery. The infiltration of the surgical incision with local anesthetics has been increasingly used to reduce pain and other analgesic use. However, little is known about the effect of this injection on healing. The objective is to evaluate the interference of local anesthetics in the area of inflammatory infiltrate and fibrosis scar in rats. Methods: Two linear incisions each were made on the dorsal region of 40 Wistar rats. The left incision was infiltrated with doses of 1.8ml of bupivacaine, levobupivacaine, ropivacaine, or 0,9% saline solution infiltration. The right incision did not receive infiltration, serving as a control group. After seven days, samples of the incisions were collected for histological morphometric evaluation. Results: When compared with the control groups, the area of inflammatory infiltrate was found larger in the bupivacaine, ropivacaine, and levobupivacaine groups. The bupivacaine group presented a larger inflammatory infiltrate than the levobupivacaine and ropivacaine. The fibrous scar area was larger in the levobupivacaine and ropivacaine groups. There was no difference between the groups that received anesthetic and saline solution. Conclusion: As there was no difference between the anesthetics and saline solution groups, the volume applied, or the trauma may have been the cause of the larger areas of infiltrating and scar associated with local anesthetics application.http://www.rbcp.org.br/export-pdf/3027/en_v36n4a09.pdf inflammationbupivacainelevobupivacaineropivacainecicatrix |
| spellingShingle | Maida Silva Calçado Élia Cláudia De Souza Almeida Luciano Alves Matias Silveira Gizele Costa Oliveira Ana Carolina Gonçalves Beatriz Junqueira Mattar Renata Margarida Etchebehere Infiltration of local anesthetics into the surgical wound: effect on inflammation and fibrous scar in rats Revista Brasileira de Cirurgia Plástica inflammation bupivacaine levobupivacaine ropivacaine cicatrix |
| title | Infiltration of local anesthetics into the surgical
wound: effect on inflammation and fibrous scar in rats |
| title_full | Infiltration of local anesthetics into the surgical
wound: effect on inflammation and fibrous scar in rats |
| title_fullStr | Infiltration of local anesthetics into the surgical
wound: effect on inflammation and fibrous scar in rats |
| title_full_unstemmed | Infiltration of local anesthetics into the surgical
wound: effect on inflammation and fibrous scar in rats |
| title_short | Infiltration of local anesthetics into the surgical
wound: effect on inflammation and fibrous scar in rats |
| title_sort | infiltration of local anesthetics into the surgical wound effect on inflammation and fibrous scar in rats |
| topic | inflammation bupivacaine levobupivacaine ropivacaine cicatrix |
| url | http://www.rbcp.org.br/export-pdf/3027/en_v36n4a09.pdf |
| work_keys_str_mv | AT maidasilvacalcado infiltrationoflocalanestheticsintothesurgicalwoundeffectoninflammationandfibrousscarinrats AT eliaclaudiadesouzaalmeida infiltrationoflocalanestheticsintothesurgicalwoundeffectoninflammationandfibrousscarinrats AT lucianoalvesmatiassilveira infiltrationoflocalanestheticsintothesurgicalwoundeffectoninflammationandfibrousscarinrats AT gizelecostaoliveira infiltrationoflocalanestheticsintothesurgicalwoundeffectoninflammationandfibrousscarinrats AT anacarolinagoncalves infiltrationoflocalanestheticsintothesurgicalwoundeffectoninflammationandfibrousscarinrats AT beatrizjunqueiramattar infiltrationoflocalanestheticsintothesurgicalwoundeffectoninflammationandfibrousscarinrats AT renatamargaridaetchebehere infiltrationoflocalanestheticsintothesurgicalwoundeffectoninflammationandfibrousscarinrats |