NO Pain! No Cancer? The Crosstalk Between Nociception, ROS, and Cancer Development
Transient receptor potential (TRP) channels, particularly those involved in nociception (nociceptive TRP channels), are implicated in both pain and cancer development. Activation of these channels by diverse stimuli triggers calcium influx, leading to mitochondrial oxidative stress and reactive oxyg...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-03-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/3/10.31083/FBL31328 |
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| author | Tzu-Yin Chen Tohru Yoshioka Wen-Li Hsu |
| author_facet | Tzu-Yin Chen Tohru Yoshioka Wen-Li Hsu |
| author_sort | Tzu-Yin Chen |
| collection | DOAJ |
| description | Transient receptor potential (TRP) channels, particularly those involved in nociception (nociceptive TRP channels), are implicated in both pain and cancer development. Activation of these channels by diverse stimuli triggers calcium influx, leading to mitochondrial oxidative stress and reactive oxygen species (ROS) accumulation. This ROS production contributes to both nociceptive signaling (causing pain) and aging processes, including genomic instability, a key driver of carcinogenesis. Although a direct causal link between pain and cancer onset remains elusive, the shared involvement of nociceptive TRP channels strongly suggests a correlation. This opinion article proposes targeting the crosstalk between nociceptive TRP channels and ROS as a promising therapeutic strategy to mitigate cancer and cancer-associated pain simultaneously. While further research is needed to definitively establish a causal relationship between pain and cancer risk, the available evidence suggests that inhibiting this pathway may offer significant benefits for both cancer prevention and treatment. |
| format | Article |
| id | doaj-art-4cd71b618fe7421b8c4e57a89f076002 |
| institution | Kabale University |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-4cd71b618fe7421b8c4e57a89f0760022025-08-20T03:42:25ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-03-013033132810.31083/FBL31328S2768-6701(25)01657-0NO Pain! No Cancer? The Crosstalk Between Nociception, ROS, and Cancer DevelopmentTzu-Yin Chen0Tohru Yoshioka1Wen-Li Hsu2National Center for Geriatrics and Welfare Research, National Health Research Institutes, 632007 Yunlin, TaiwanRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, 80708 Kaohsiung, TaiwanNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 632007 Yunlin, TaiwanTransient receptor potential (TRP) channels, particularly those involved in nociception (nociceptive TRP channels), are implicated in both pain and cancer development. Activation of these channels by diverse stimuli triggers calcium influx, leading to mitochondrial oxidative stress and reactive oxygen species (ROS) accumulation. This ROS production contributes to both nociceptive signaling (causing pain) and aging processes, including genomic instability, a key driver of carcinogenesis. Although a direct causal link between pain and cancer onset remains elusive, the shared involvement of nociceptive TRP channels strongly suggests a correlation. This opinion article proposes targeting the crosstalk between nociceptive TRP channels and ROS as a promising therapeutic strategy to mitigate cancer and cancer-associated pain simultaneously. While further research is needed to definitively establish a causal relationship between pain and cancer risk, the available evidence suggests that inhibiting this pathway may offer significant benefits for both cancer prevention and treatment.https://www.imrpress.com/journal/FBL/30/3/10.31083/FBL31328nociceptive transient receptor potential channelcancer progressionpainmitochondrial ca2+ overloadros |
| spellingShingle | Tzu-Yin Chen Tohru Yoshioka Wen-Li Hsu NO Pain! No Cancer? The Crosstalk Between Nociception, ROS, and Cancer Development Frontiers in Bioscience-Landmark nociceptive transient receptor potential channel cancer progression pain mitochondrial ca2+ overload ros |
| title | NO Pain! No Cancer? The Crosstalk Between Nociception, ROS, and Cancer Development |
| title_full | NO Pain! No Cancer? The Crosstalk Between Nociception, ROS, and Cancer Development |
| title_fullStr | NO Pain! No Cancer? The Crosstalk Between Nociception, ROS, and Cancer Development |
| title_full_unstemmed | NO Pain! No Cancer? The Crosstalk Between Nociception, ROS, and Cancer Development |
| title_short | NO Pain! No Cancer? The Crosstalk Between Nociception, ROS, and Cancer Development |
| title_sort | no pain no cancer the crosstalk between nociception ros and cancer development |
| topic | nociceptive transient receptor potential channel cancer progression pain mitochondrial ca2+ overload ros |
| url | https://www.imrpress.com/journal/FBL/30/3/10.31083/FBL31328 |
| work_keys_str_mv | AT tzuyinchen nopainnocancerthecrosstalkbetweennociceptionrosandcancerdevelopment AT tohruyoshioka nopainnocancerthecrosstalkbetweennociceptionrosandcancerdevelopment AT wenlihsu nopainnocancerthecrosstalkbetweennociceptionrosandcancerdevelopment |