Mapping striatal functional gradients and associated gene expression in Parkinson’s disease with continuous cognitive impairment

Mapping striatal functional gradients and associated gene expression in Parkinson’s disease with continuous cognitive impairment

Abstract Cognitive impairment in Parkinson’s disease is closely tied to striatal dysfunction, yet the neurobiological interface between macroscale connectivity and molecular signatures remains unexplored. This study characterizes striatal gradient organization and its genetic underpinnings across PD...

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Bibliographic Details
Main Authors: Xiaolu Li, Shuting Bu, Huize Pang, Hongmei Yu, Mengwan Zhao, Juzhou Wang, Yu Liu, Guoguang Fan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01002-2
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