Sex related disparities after complex percutaneous coronary interventions
IntroductionComplex Percutaneous coronary intervention (PCI) for the treatment of ischemic heart disease has increased significantly. We aimed to evaluate sex-related differences in patients undergoing complex PCI.Methodssingle-center prospective observational study including patients undergoing com...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1382585/full |
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| author | Alberto Alperi Alberto Alperi Marcel Almendárez Marcel Almendárez Marcel Almendárez Isaac Pascual Isaac Pascual Isaac Pascual Rut Alvarez Jose Luis Betanzos Daniel Hernández-Vaquero Daniel Hernández-Vaquero Daniel Hernández-Vaquero Raul Ptaszynski Raul Ptaszynski Juan Francisco Ortiz Cesar Moris Cesar Moris Cesar Moris Pablo Avanzas Pablo Avanzas Pablo Avanzas Pablo Avanzas |
| author_facet | Alberto Alperi Alberto Alperi Marcel Almendárez Marcel Almendárez Marcel Almendárez Isaac Pascual Isaac Pascual Isaac Pascual Rut Alvarez Jose Luis Betanzos Daniel Hernández-Vaquero Daniel Hernández-Vaquero Daniel Hernández-Vaquero Raul Ptaszynski Raul Ptaszynski Juan Francisco Ortiz Cesar Moris Cesar Moris Cesar Moris Pablo Avanzas Pablo Avanzas Pablo Avanzas Pablo Avanzas |
| author_sort | Alberto Alperi |
| collection | DOAJ |
| description | IntroductionComplex Percutaneous coronary intervention (PCI) for the treatment of ischemic heart disease has increased significantly. We aimed to evaluate sex-related differences in patients undergoing complex PCI.Methodssingle-center prospective observational study including patients undergoing complex PCI between 2017 and 2023. Baseline and procedural features, and mid-term outcomes were compared according to the gender distribution. The combined primary endpoint included stroke, myocardial infarction, need for a new coronary revascularization, and all-cause mortality. Propensity score (PS) matching with an inverse probability of treatment weight (IPW) approach was used to adjust for differences in baseline characteristics.Results1,283 patients were included, 983 (76.6%) male and 300 (23.4%) female. Median follow-up was 2.4 (IQR: 1–3.8) years. There was a higher rate of no-reflow phenomenon (4% vs. 1.8%, p = 0.03) among female patients. In the overall cohort, female patients had a greater risk for the combined primary endpoint (HR 1.28, 95% CI: 1.02–1.59). In the matched cohort, female patients exhibited a higher risk for the combined primary endpoint (HR 1.23, 95% CI: 1.06–1.42), as well as for myocardial infarction (HR 1.34, 95% CI 1.03–1.75), and all-cause mortality (HR 1.21, 95% CI 1.02–1.45), and a trend towards a higher risk for the need of a new coronary revascularization (HR 1.22, 95% CI 0.92–1.61).Conclusionsin a contemporary cohort of patients undergoing complex PCI procedures, female patients are associated with a higher risk of early complications. |
| format | Article |
| id | doaj-art-4cd4489680d14575b02861b8be17bd28 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-4cd4489680d14575b02861b8be17bd282025-08-20T02:12:42ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-11-011110.3389/fcvm.2024.13825851382585Sex related disparities after complex percutaneous coronary interventionsAlberto Alperi0Alberto Alperi1Marcel Almendárez2Marcel Almendárez3Marcel Almendárez4Isaac Pascual5Isaac Pascual6Isaac Pascual7Rut Alvarez8Jose Luis Betanzos9Daniel Hernández-Vaquero10Daniel Hernández-Vaquero11Daniel Hernández-Vaquero12Raul Ptaszynski13Raul Ptaszynski14Juan Francisco Ortiz15Cesar Moris16Cesar Moris17Cesar Moris18Pablo Avanzas19Pablo Avanzas20Pablo Avanzas21Pablo Avanzas22Department of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Health Research Institute of Asturias (Instituto de Iinvestigación Sanitaria del Principado de Asturias), Oviedo, SpainDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Health Research Institute of Asturias (Instituto de Iinvestigación Sanitaria del Principado de Asturias), Oviedo, SpainDepartment of Medicine, Faculty of Medicine, University of Oviedo, Oviedo, SpainDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Health Research Institute of Asturias (Instituto de Iinvestigación Sanitaria del Principado de Asturias), Oviedo, SpainDepartment of Medicine, Faculty of Medicine, University of Oviedo, Oviedo, SpainDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Health Research Institute of Asturias (Instituto de Iinvestigación Sanitaria del Principado de Asturias), Oviedo, SpainDepartment of Medicine, Faculty of Medicine, University of Oviedo, Oviedo, SpainDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Health Research Institute of Asturias (Instituto de Iinvestigación Sanitaria del Principado de Asturias), Oviedo, SpainDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Health Research Institute of Asturias (Instituto de Iinvestigación Sanitaria del Principado de Asturias), Oviedo, SpainDepartment of Medicine, Faculty of Medicine, University of Oviedo, Oviedo, SpainDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, SpainDepartment of Cardiology, Health Research Institute of Asturias (Instituto de Iinvestigación Sanitaria del Principado de Asturias), Oviedo, SpainDepartment of Medicine, Faculty of Medicine, University of Oviedo, Oviedo, SpainDepartment of Cardiology, Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, SpainIntroductionComplex Percutaneous coronary intervention (PCI) for the treatment of ischemic heart disease has increased significantly. We aimed to evaluate sex-related differences in patients undergoing complex PCI.Methodssingle-center prospective observational study including patients undergoing complex PCI between 2017 and 2023. Baseline and procedural features, and mid-term outcomes were compared according to the gender distribution. The combined primary endpoint included stroke, myocardial infarction, need for a new coronary revascularization, and all-cause mortality. Propensity score (PS) matching with an inverse probability of treatment weight (IPW) approach was used to adjust for differences in baseline characteristics.Results1,283 patients were included, 983 (76.6%) male and 300 (23.4%) female. Median follow-up was 2.4 (IQR: 1–3.8) years. There was a higher rate of no-reflow phenomenon (4% vs. 1.8%, p = 0.03) among female patients. In the overall cohort, female patients had a greater risk for the combined primary endpoint (HR 1.28, 95% CI: 1.02–1.59). In the matched cohort, female patients exhibited a higher risk for the combined primary endpoint (HR 1.23, 95% CI: 1.06–1.42), as well as for myocardial infarction (HR 1.34, 95% CI 1.03–1.75), and all-cause mortality (HR 1.21, 95% CI 1.02–1.45), and a trend towards a higher risk for the need of a new coronary revascularization (HR 1.22, 95% CI 0.92–1.61).Conclusionsin a contemporary cohort of patients undergoing complex PCI procedures, female patients are associated with a higher risk of early complications.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1382585/fullcoronary artery diseasepercutaneous coronary interventioncomplex PCImyocardial infarctionsex-related differences inverse probability of treatment weight |
| spellingShingle | Alberto Alperi Alberto Alperi Marcel Almendárez Marcel Almendárez Marcel Almendárez Isaac Pascual Isaac Pascual Isaac Pascual Rut Alvarez Jose Luis Betanzos Daniel Hernández-Vaquero Daniel Hernández-Vaquero Daniel Hernández-Vaquero Raul Ptaszynski Raul Ptaszynski Juan Francisco Ortiz Cesar Moris Cesar Moris Cesar Moris Pablo Avanzas Pablo Avanzas Pablo Avanzas Pablo Avanzas Sex related disparities after complex percutaneous coronary interventions Frontiers in Cardiovascular Medicine coronary artery disease percutaneous coronary intervention complex PCI myocardial infarction sex-related differences inverse probability of treatment weight |
| title | Sex related disparities after complex percutaneous coronary interventions |
| title_full | Sex related disparities after complex percutaneous coronary interventions |
| title_fullStr | Sex related disparities after complex percutaneous coronary interventions |
| title_full_unstemmed | Sex related disparities after complex percutaneous coronary interventions |
| title_short | Sex related disparities after complex percutaneous coronary interventions |
| title_sort | sex related disparities after complex percutaneous coronary interventions |
| topic | coronary artery disease percutaneous coronary intervention complex PCI myocardial infarction sex-related differences inverse probability of treatment weight |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1382585/full |
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