Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat
Objective: This study aims to map the distribution of the Aspartate 614 to Glycine (Asp614Gly) mutation in the spike protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) circulating in West Sumatra, to understand the extent of its spread within the local population. Methods: R...
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| Format: | Article |
| Language: | English |
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Universitas Andalas
2024-05-01
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| Series: | Majalah Kedokteran Andalas |
| Online Access: | https://jurnalmka.fk.unand.ac.id/index.php/art/article/view/1529 |
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| author | Dede Rahman Agustian Andani Eka Putra Dessy Arisanty |
| author_facet | Dede Rahman Agustian Andani Eka Putra Dessy Arisanty |
| author_sort | Dede Rahman Agustian |
| collection | DOAJ |
| description | Objective: This study aims to map the distribution of the Aspartate 614 to Glycine (Asp614Gly) mutation in the spike protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) circulating in West Sumatra, to understand the extent of its spread within the local population. Methods: RNA samples were taken from 98 confirmed COVID-19 cases across various area in West Sumatra. Genetic amplification and next-generation sequencing (NGS) were performed to identify the presence of the Asp614Gly mutation. The frequency of mutations was analyzed using bioinformatics software. Results: Out of the 98 samples analyzed, approximately 97% exhibited the Asp614Gly mutation. The geographic distribution of this mutation showed significant variation among the districts of West Sumatra, with the highest prevalence in urban areas. Conclusion: These findings indicate that the Asp614Gly mutation is highly prevalent in West Sumatra. Associated with increased virus transmissibility, this mutation dominates the circulating virus strains in the region, highlighting the need for ongoing genetic surveillance to guide public health interventions and vaccination strategies. |
| format | Article |
| id | doaj-art-4cd30a3e9baf47e8bf444093ef0b3446 |
| institution | Kabale University |
| issn | 0126-2092 2442-5230 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Universitas Andalas |
| record_format | Article |
| series | Majalah Kedokteran Andalas |
| spelling | doaj-art-4cd30a3e9baf47e8bf444093ef0b34462024-11-12T02:06:22ZengUniversitas AndalasMajalah Kedokteran Andalas0126-20922442-52302024-05-0146101724173310.25077/mka.v46.i10.p1724-1733.2024861Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera BaratDede Rahman Agustian0Andani Eka PutraDessy ArisantyDoctoral Program Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia/ Department of Medical Laboratory Technology, STIKES Syedza Saintika, Padang, IndonesiaObjective: This study aims to map the distribution of the Aspartate 614 to Glycine (Asp614Gly) mutation in the spike protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) circulating in West Sumatra, to understand the extent of its spread within the local population. Methods: RNA samples were taken from 98 confirmed COVID-19 cases across various area in West Sumatra. Genetic amplification and next-generation sequencing (NGS) were performed to identify the presence of the Asp614Gly mutation. The frequency of mutations was analyzed using bioinformatics software. Results: Out of the 98 samples analyzed, approximately 97% exhibited the Asp614Gly mutation. The geographic distribution of this mutation showed significant variation among the districts of West Sumatra, with the highest prevalence in urban areas. Conclusion: These findings indicate that the Asp614Gly mutation is highly prevalent in West Sumatra. Associated with increased virus transmissibility, this mutation dominates the circulating virus strains in the region, highlighting the need for ongoing genetic surveillance to guide public health interventions and vaccination strategies.https://jurnalmka.fk.unand.ac.id/index.php/art/article/view/1529 |
| spellingShingle | Dede Rahman Agustian Andani Eka Putra Dessy Arisanty Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat Majalah Kedokteran Andalas |
| title | Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat |
| title_full | Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat |
| title_fullStr | Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat |
| title_full_unstemmed | Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat |
| title_short | Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat |
| title_sort | distribusi mutasi asp614gly pada spike protein sars cov 2 di sumatera barat |
| url | https://jurnalmka.fk.unand.ac.id/index.php/art/article/view/1529 |
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