The Impact of Helicobacter pylori on Lesion Type and Matrix Metalloproteinase-9 Expression in Laryngeal Tumors
Background: Helicobacter pylori and matrix metalloproteinase-9 (MMP-9) play a significant part in the pathophysiological processes and expression of carcinogenesis, particularly in laryngeal Squamous Cell Carcinoma (LSCC). Objective: Explore the link between the H. pylori bacterium, MMP-9 express...
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College of medicine/ University of Diyala
2025-04-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | https://djm.uodiyala.edu.iq/index.php/djm/article/view/1250 |
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| author | Wasan Abdul-elah Bakir Refif Sabih Al-Shawk Mais Ibrahim Alsikafi Shaimaa Rahem Al-Salihy |
| author_facet | Wasan Abdul-elah Bakir Refif Sabih Al-Shawk Mais Ibrahim Alsikafi Shaimaa Rahem Al-Salihy |
| author_sort | Wasan Abdul-elah Bakir |
| collection | DOAJ |
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Background: Helicobacter pylori and matrix metalloproteinase-9 (MMP-9) play a significant part in the pathophysiological processes and expression of carcinogenesis, particularly in laryngeal Squamous Cell Carcinoma (LSCC).
Objective: Explore the link between the H. pylori bacterium, MMP-9 expression, and laryngeal squamous cell carcinoma development by examining the role of chronic inflammation and extracellular matrix remodeling in laryngeal carcinogenesis.
Patients and Methods: This cross-sectional study recruited 118 tissue samples, including 58 malignant LSCC and 60 benign laryngeal polyps (BLP). Histopathological and immunohistochemical methods were used to assess the interplay of H. pylori, MMP-9, and smoking status in laryngeal tumors.
Results: The prevalence of H. pylori was significantly higher in malignant lesions (63.79%) as compared to benign lesions (51.66%) (p=0.1). A significant correlation was found in patients with benign lesions between the level of MMP-9 and smoking and H. pylori status (r = 0.46, p = 0.001), and (r = 0.5, p = 0.001), respectively. While in patients with malignant lesions, the correlation test revealed a significant negative correlation between the level of MMP-9 and smoking status (r = -0.41, p 0.001), while H. pylori is a highest positively correlated with MMP-9 expression (r = 0.5, p = 0.001). The logistic regression analysis revealed that H. pylori infection could significantly predict high MMP-9 expression (OR =3.08, 95% CI: 1.15-8.28, p = 0.02).
Conclusion: These findings highlight the crucial role of H. pylori infection and smoking in tumor progression through MMP-9-mediated extracellular matrix remodeling, inflammation, and immune modulation. Suggesting the potential impact of targeting H. pylori infection and MMP-9 activity for managing carcinogenesis.
Keywords: Helicobacter pylori, MMP-9, laryngeal squamous cell carcinoma, Benign laryngeal polyps.
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| format | Article |
| id | doaj-art-4cce440ce2ef40daa4207e58a3f71577 |
| institution | Kabale University |
| issn | 2219-9764 2617-8982 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj-art-4cce440ce2ef40daa4207e58a3f715772025-08-20T03:48:31ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822025-04-0128110.26505/djm.v28i1.1250The Impact of Helicobacter pylori on Lesion Type and Matrix Metalloproteinase-9 Expression in Laryngeal TumorsWasan Abdul-elah Bakir0Refif Sabih Al-Shawk1Mais Ibrahim Alsikafi2Shaimaa Rahem Al-Salihy3Department of Microbiology, College of Medicine, Mustansiriyah University, Baghdad, Iraq.Department of Microbiology, College of Medicine, Mustansiriyah University, Baghdad, Iraq.Department of Pathology, College of Medicine, Mustansiriyah University, Baghdad, Iraq.Department of Microbiology, College of Medicine, University of Diyala, Diyala, Iraq. Background: Helicobacter pylori and matrix metalloproteinase-9 (MMP-9) play a significant part in the pathophysiological processes and expression of carcinogenesis, particularly in laryngeal Squamous Cell Carcinoma (LSCC). Objective: Explore the link between the H. pylori bacterium, MMP-9 expression, and laryngeal squamous cell carcinoma development by examining the role of chronic inflammation and extracellular matrix remodeling in laryngeal carcinogenesis. Patients and Methods: This cross-sectional study recruited 118 tissue samples, including 58 malignant LSCC and 60 benign laryngeal polyps (BLP). Histopathological and immunohistochemical methods were used to assess the interplay of H. pylori, MMP-9, and smoking status in laryngeal tumors. Results: The prevalence of H. pylori was significantly higher in malignant lesions (63.79%) as compared to benign lesions (51.66%) (p=0.1). A significant correlation was found in patients with benign lesions between the level of MMP-9 and smoking and H. pylori status (r = 0.46, p = 0.001), and (r = 0.5, p = 0.001), respectively. While in patients with malignant lesions, the correlation test revealed a significant negative correlation between the level of MMP-9 and smoking status (r = -0.41, p 0.001), while H. pylori is a highest positively correlated with MMP-9 expression (r = 0.5, p = 0.001). The logistic regression analysis revealed that H. pylori infection could significantly predict high MMP-9 expression (OR =3.08, 95% CI: 1.15-8.28, p = 0.02). Conclusion: These findings highlight the crucial role of H. pylori infection and smoking in tumor progression through MMP-9-mediated extracellular matrix remodeling, inflammation, and immune modulation. Suggesting the potential impact of targeting H. pylori infection and MMP-9 activity for managing carcinogenesis. Keywords: Helicobacter pylori, MMP-9, laryngeal squamous cell carcinoma, Benign laryngeal polyps. https://djm.uodiyala.edu.iq/index.php/djm/article/view/1250Helicobacter pyloriMMP-9laryngeal Squamous Cell Carcinomabenign laryngeal polyps |
| spellingShingle | Wasan Abdul-elah Bakir Refif Sabih Al-Shawk Mais Ibrahim Alsikafi Shaimaa Rahem Al-Salihy The Impact of Helicobacter pylori on Lesion Type and Matrix Metalloproteinase-9 Expression in Laryngeal Tumors Diyala Journal of Medicine Helicobacter pylori MMP-9 laryngeal Squamous Cell Carcinoma benign laryngeal polyps |
| title | The Impact of Helicobacter pylori on Lesion Type and Matrix Metalloproteinase-9 Expression in Laryngeal Tumors |
| title_full | The Impact of Helicobacter pylori on Lesion Type and Matrix Metalloproteinase-9 Expression in Laryngeal Tumors |
| title_fullStr | The Impact of Helicobacter pylori on Lesion Type and Matrix Metalloproteinase-9 Expression in Laryngeal Tumors |
| title_full_unstemmed | The Impact of Helicobacter pylori on Lesion Type and Matrix Metalloproteinase-9 Expression in Laryngeal Tumors |
| title_short | The Impact of Helicobacter pylori on Lesion Type and Matrix Metalloproteinase-9 Expression in Laryngeal Tumors |
| title_sort | impact of helicobacter pylori on lesion type and matrix metalloproteinase 9 expression in laryngeal tumors |
| topic | Helicobacter pylori MMP-9 laryngeal Squamous Cell Carcinoma benign laryngeal polyps |
| url | https://djm.uodiyala.edu.iq/index.php/djm/article/view/1250 |
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