Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM).
Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to th...
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Public Library of Science (PLoS)
2015-01-01
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| author | Amir Ahmadi Jonathon Leipsic Gudrun Feuchtner Heidi Gransar Dan Kalra Ran Heo Stephan Achenbach Daniele Andreini Mouaz Al-Mallah Daniel S Berman Matthew Budoff Filippo Cademartiri Tracy Q Callister Hyuk-Jae Chang Kavitha Chinnaiyan Benjamin Chow Ricardo C Cury Augustin Delago Millie J Gomez Martin Hadamitzky Joerg Hausleiter Niree Hindoyan Philipp A Kaufmann Yong-Jin Kim Fay Lin Erica Maffei Gianluca Pontone Gilbert L Raff Leslee J Shaw Todd C Villines Allison Dunning James K Min |
| author_facet | Amir Ahmadi Jonathon Leipsic Gudrun Feuchtner Heidi Gransar Dan Kalra Ran Heo Stephan Achenbach Daniele Andreini Mouaz Al-Mallah Daniel S Berman Matthew Budoff Filippo Cademartiri Tracy Q Callister Hyuk-Jae Chang Kavitha Chinnaiyan Benjamin Chow Ricardo C Cury Augustin Delago Millie J Gomez Martin Hadamitzky Joerg Hausleiter Niree Hindoyan Philipp A Kaufmann Yong-Jin Kim Fay Lin Erica Maffei Gianluca Pontone Gilbert L Raff Leslee J Shaw Todd C Villines Allison Dunning James K Min |
| author_sort | Amir Ahmadi |
| collection | DOAJ |
| description | Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥ 64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n = 690) were matched 1:1:1 to those with 1 component (n = 690) and 2 components (n = 690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p < 0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p > 0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p = 0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p = 0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome. |
| format | Article |
| id | doaj-art-4ccd8c87bc6247368b2b9dce4394bc51 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-4ccd8c87bc6247368b2b9dce4394bc512025-08-20T03:10:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011899810.1371/journal.pone.0118998Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM).Amir AhmadiJonathon LeipsicGudrun FeuchtnerHeidi GransarDan KalraRan HeoStephan AchenbachDaniele AndreiniMouaz Al-MallahDaniel S BermanMatthew BudoffFilippo CademartiriTracy Q CallisterHyuk-Jae ChangKavitha ChinnaiyanBenjamin ChowRicardo C CuryAugustin DelagoMillie J GomezMartin HadamitzkyJoerg HausleiterNiree HindoyanPhilipp A KaufmannYong-Jin KimFay LinErica MaffeiGianluca PontoneGilbert L RaffLeslee J ShawTodd C VillinesAllison DunningJames K MinAlthough metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥ 64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n = 690) were matched 1:1:1 to those with 1 component (n = 690) and 2 components (n = 690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p < 0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p > 0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p = 0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p = 0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118998&type=printable |
| spellingShingle | Amir Ahmadi Jonathon Leipsic Gudrun Feuchtner Heidi Gransar Dan Kalra Ran Heo Stephan Achenbach Daniele Andreini Mouaz Al-Mallah Daniel S Berman Matthew Budoff Filippo Cademartiri Tracy Q Callister Hyuk-Jae Chang Kavitha Chinnaiyan Benjamin Chow Ricardo C Cury Augustin Delago Millie J Gomez Martin Hadamitzky Joerg Hausleiter Niree Hindoyan Philipp A Kaufmann Yong-Jin Kim Fay Lin Erica Maffei Gianluca Pontone Gilbert L Raff Leslee J Shaw Todd C Villines Allison Dunning James K Min Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM). PLoS ONE |
| title | Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM). |
| title_full | Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM). |
| title_fullStr | Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM). |
| title_full_unstemmed | Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM). |
| title_short | Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM). |
| title_sort | is metabolic syndrome predictive of prevalence extent and risk of coronary artery disease beyond its components results from the multinational coronary ct angiography evaluation for clinical outcome an international multicenter registry confirm |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118998&type=printable |
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