Cytokine Levels in the Serum of Healthy Subjects
Growing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response. Indeed, when the cytokine production is deregulated, diseases...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/434010 |
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| _version_ | 1832564257188741120 |
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| author | Giulio Kleiner Annalisa Marcuzzi Valentina Zanin Lorenzo Monasta Giorgio Zauli |
| author_facet | Giulio Kleiner Annalisa Marcuzzi Valentina Zanin Lorenzo Monasta Giorgio Zauli |
| author_sort | Giulio Kleiner |
| collection | DOAJ |
| description | Growing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response. Indeed, when the cytokine production is deregulated, diseases often occur. The understanding of the physiological mechanism of the cytokine network would be useful to better comprehend pathological conditions. Moreover, since the immune system and response change their properties with development, differences in patients' age should be taken into account, both in physiological and in pathological conditions. In this study, we analyzed the profile of 48 cytokines and chemokines in the serum of healthy subjects, comparing adults (≥18 years) with young children and children (1–6 and 7–17 years). We found that a certain number of cytokines were not being produced in healthy subjects; others showed a constant serum level amongst the groups. Certain cytokines exhibited a downward or an upward trend with increasing age. The remaining cytokines were up- or downregulated in the group of the children with respect to the other groups. In conclusion, we drew some kinds of guidelines about the physiological production of cytokines and chemokines, underling the difference caused by aging. |
| format | Article |
| id | doaj-art-4ccd717322274a9fb236e50a36c57cac |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4ccd717322274a9fb236e50a36c57cac2025-02-03T01:11:29ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/434010434010Cytokine Levels in the Serum of Healthy SubjectsGiulio Kleiner0Annalisa Marcuzzi1Valentina Zanin2Lorenzo Monasta3Giorgio Zauli4Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” Via dell'Istria, 65/1, 34137 Trieste, ItalyInstitute for Maternal and Child Health, IRCCS “Burlo Garofolo,” Via dell'Istria, 65/1, 34137 Trieste, ItalyInstitute for Maternal and Child Health, IRCCS “Burlo Garofolo,” Via dell'Istria, 65/1, 34137 Trieste, ItalyInstitute for Maternal and Child Health, IRCCS “Burlo Garofolo,” Via dell'Istria, 65/1, 34137 Trieste, ItalyInstitute for Maternal and Child Health, IRCCS “Burlo Garofolo,” Via dell'Istria, 65/1, 34137 Trieste, ItalyGrowing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response. Indeed, when the cytokine production is deregulated, diseases often occur. The understanding of the physiological mechanism of the cytokine network would be useful to better comprehend pathological conditions. Moreover, since the immune system and response change their properties with development, differences in patients' age should be taken into account, both in physiological and in pathological conditions. In this study, we analyzed the profile of 48 cytokines and chemokines in the serum of healthy subjects, comparing adults (≥18 years) with young children and children (1–6 and 7–17 years). We found that a certain number of cytokines were not being produced in healthy subjects; others showed a constant serum level amongst the groups. Certain cytokines exhibited a downward or an upward trend with increasing age. The remaining cytokines were up- or downregulated in the group of the children with respect to the other groups. In conclusion, we drew some kinds of guidelines about the physiological production of cytokines and chemokines, underling the difference caused by aging.http://dx.doi.org/10.1155/2013/434010 |
| spellingShingle | Giulio Kleiner Annalisa Marcuzzi Valentina Zanin Lorenzo Monasta Giorgio Zauli Cytokine Levels in the Serum of Healthy Subjects Mediators of Inflammation |
| title | Cytokine Levels in the Serum of Healthy Subjects |
| title_full | Cytokine Levels in the Serum of Healthy Subjects |
| title_fullStr | Cytokine Levels in the Serum of Healthy Subjects |
| title_full_unstemmed | Cytokine Levels in the Serum of Healthy Subjects |
| title_short | Cytokine Levels in the Serum of Healthy Subjects |
| title_sort | cytokine levels in the serum of healthy subjects |
| url | http://dx.doi.org/10.1155/2013/434010 |
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