Manejo de niños con Hepatitis Autoinmune en un Hospital de Especialidades Pediátricas. Serie de casos
Introduction: Autoimmune Hepatitis (AIH) a rare dis-ease. Defined as a chronic, progressive inflammatory liver disease characterized by inflammation and fibrosis of the liver parenchyma and the intra-and/or extrahepatic biliary tree associated with the presence of autoantibodies and ele...
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Colegio Médico de Honduras
2025-03-01
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| Series: | Revista Médica Hondureña |
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| Online Access: | https://www.camjol.info/index.php/RMH/article/view/19508 |
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| author | Dina Raquel Álvarez Corrales Delia Gertrudys Padilla Dilcia Esperanza Sauceda Acosta Nazaret Celeste Yanes Reyes Rosa de Lourdes Aguilar Ordóñez |
| author_facet | Dina Raquel Álvarez Corrales Delia Gertrudys Padilla Dilcia Esperanza Sauceda Acosta Nazaret Celeste Yanes Reyes Rosa de Lourdes Aguilar Ordóñez |
| author_sort | Dina Raquel Álvarez Corrales |
| collection | DOAJ |
| description | Introduction: Autoimmune Hepatitis (AIH) a rare dis-ease. Defined as a chronic, progressive inflammatory liver disease characterized by inflammation and fibrosis of the liver parenchyma and the intra-and/or extrahepatic biliary tree associated with the presence of autoantibodies and elevation of immunoglobulin G (IgG). The clinical presentation is variable. The diagnosis requires the combination of clinical, laboratory, immunological and histo-logical criteria presented in the diagnostic guide of the International Autoimmune Hepatitis Group (IAIHG). Honduras has few publica-tions on the frequency of HAI, so this study was carried out to describe the experience in the management of patients with HAI at the Hospital María, Pediatric Specialties (HMEP) from 2017-2022. Case description: 19 cases were found; the mean age was 10 years (standard deviation SD of 4.6). The female sex was the most affected. In 10.5% (2/19) of patients, a first degree relative with au-toimmune disease was identified. 42.1% (8/19) had comorbidities of 50% (4/8) suffered from Systemic Lupus Erythematosus. The initial levels were found to be high and the biopsy performed in all cases was of typical histology for AIH in 63.5% (12/19) and 36.8% (7/19) compatible for AIH. All patients were treated with a combina-tion of oral steroid and immunosuppressant mainly azathioprine. No mortality was recorded. Conclusion: AIH in pediatrics should be suspected and diagnostic aid criteria applied. A favorable clini-cal response was obtained in this group of patients. |
| format | Article |
| id | doaj-art-4cc8525da1394d78b46446b08f841bd3 |
| institution | OA Journals |
| issn | 0375-1112 1995-7068 |
| language | Spanish |
| publishDate | 2025-03-01 |
| publisher | Colegio Médico de Honduras |
| record_format | Article |
| series | Revista Médica Hondureña |
| spelling | doaj-art-4cc8525da1394d78b46446b08f841bd32025-08-20T02:27:22ZspaColegio Médico de HondurasRevista Médica Hondureña0375-11121995-70682025-03-0192Suplemento 2333810.5377/rmh.v92iSupl.2.19508Manejo de niños con Hepatitis Autoinmune en un Hospital de Especialidades Pediátricas. Serie de casosDina Raquel Álvarez Corrales0https://orcid.org/0000-0001-8778-3869Delia Gertrudys Padilla1https://orcid.org/0000-0001-6582-1377Dilcia Esperanza Sauceda Acosta2https://orcid.org/0000-0001-6824-5723Nazaret Celeste Yanes Reyes3https://orcid.org/0009-0005-4680-9168Rosa de Lourdes Aguilar Ordóñez4https://orcid.org/0009-0004-5607-5826Hospital María, Especialidades Pediátricas, Docencia e Investigación; Tegucigalpa, Honduras.Hospital María, Especialidades Pediátricas, Servicio de Gastroenterología; Tegucigalpa, Honduras.Hospital María, Especialidades Pediátricas, Docencia e Investigación; Tegucigalpa, Honduras. Universidad Nacional Autónoma de Honduras, Departamento de Salud Pública; Tegucigalpa, Honduras.Universidad Católica de Honduras “Nuestra Señora de la Paz”; Tegucigalpa, Honduras.Hospital María, Especialidades Pediátricas, Servicio de Inmunología y Alergia; Tegucigalpa, Honduras.Introduction: Autoimmune Hepatitis (AIH) a rare dis-ease. Defined as a chronic, progressive inflammatory liver disease characterized by inflammation and fibrosis of the liver parenchyma and the intra-and/or extrahepatic biliary tree associated with the presence of autoantibodies and elevation of immunoglobulin G (IgG). The clinical presentation is variable. The diagnosis requires the combination of clinical, laboratory, immunological and histo-logical criteria presented in the diagnostic guide of the International Autoimmune Hepatitis Group (IAIHG). Honduras has few publica-tions on the frequency of HAI, so this study was carried out to describe the experience in the management of patients with HAI at the Hospital María, Pediatric Specialties (HMEP) from 2017-2022. Case description: 19 cases were found; the mean age was 10 years (standard deviation SD of 4.6). The female sex was the most affected. In 10.5% (2/19) of patients, a first degree relative with au-toimmune disease was identified. 42.1% (8/19) had comorbidities of 50% (4/8) suffered from Systemic Lupus Erythematosus. The initial levels were found to be high and the biopsy performed in all cases was of typical histology for AIH in 63.5% (12/19) and 36.8% (7/19) compatible for AIH. All patients were treated with a combina-tion of oral steroid and immunosuppressant mainly azathioprine. No mortality was recorded. Conclusion: AIH in pediatrics should be suspected and diagnostic aid criteria applied. A favorable clini-cal response was obtained in this group of patients. https://www.camjol.info/index.php/RMH/article/view/19508autoantibodiesautoimmune hepatitispediatrics |
| spellingShingle | Dina Raquel Álvarez Corrales Delia Gertrudys Padilla Dilcia Esperanza Sauceda Acosta Nazaret Celeste Yanes Reyes Rosa de Lourdes Aguilar Ordóñez Manejo de niños con Hepatitis Autoinmune en un Hospital de Especialidades Pediátricas. Serie de casos Revista Médica Hondureña autoantibodies autoimmune hepatitis pediatrics |
| title | Manejo de niños con Hepatitis Autoinmune en un Hospital de Especialidades Pediátricas. Serie de casos |
| title_full | Manejo de niños con Hepatitis Autoinmune en un Hospital de Especialidades Pediátricas. Serie de casos |
| title_fullStr | Manejo de niños con Hepatitis Autoinmune en un Hospital de Especialidades Pediátricas. Serie de casos |
| title_full_unstemmed | Manejo de niños con Hepatitis Autoinmune en un Hospital de Especialidades Pediátricas. Serie de casos |
| title_short | Manejo de niños con Hepatitis Autoinmune en un Hospital de Especialidades Pediátricas. Serie de casos |
| title_sort | manejo de ninos con hepatitis autoinmune en un hospital de especialidades pediatricas serie de casos |
| topic | autoantibodies autoimmune hepatitis pediatrics |
| url | https://www.camjol.info/index.php/RMH/article/view/19508 |
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