Manejo de niños con Hepatitis Autoinmune en un Hospital de Especialidades Pediátricas. Serie de casos
Introduction: Autoimmune Hepatitis (AIH) a rare dis-ease. Defined as a chronic, progressive inflammatory liver disease characterized by inflammation and fibrosis of the liver parenchyma and the intra-and/or extrahepatic biliary tree associated with the presence of autoantibodies and ele...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Colegio Médico de Honduras
2025-03-01
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| Series: | Revista Médica Hondureña |
| Subjects: | |
| Online Access: | https://www.camjol.info/index.php/RMH/article/view/19508 |
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| Summary: | Introduction: Autoimmune Hepatitis (AIH) a rare dis-ease. Defined as a chronic, progressive inflammatory liver disease characterized by inflammation and fibrosis of the liver parenchyma and the intra-and/or extrahepatic biliary tree associated with the presence of autoantibodies and elevation of immunoglobulin G (IgG). The clinical presentation is variable. The diagnosis requires the combination of clinical, laboratory, immunological and histo-logical criteria presented in the diagnostic guide of the International Autoimmune Hepatitis Group (IAIHG). Honduras has few publica-tions on the frequency of HAI, so this study was carried out to describe the experience in the management of patients with HAI at the Hospital María, Pediatric Specialties (HMEP) from 2017-2022. Case description: 19 cases were found; the mean age was 10 years (standard deviation SD of 4.6). The female sex was the most affected. In 10.5% (2/19) of patients, a first degree relative with au-toimmune disease was identified. 42.1% (8/19) had comorbidities of 50% (4/8) suffered from Systemic Lupus Erythematosus. The initial levels were found to be high and the biopsy performed in all cases was of typical histology for AIH in 63.5% (12/19) and 36.8% (7/19) compatible for AIH. All patients were treated with a combina-tion of oral steroid and immunosuppressant mainly azathioprine. No mortality was recorded. Conclusion: AIH in pediatrics should be suspected and diagnostic aid criteria applied. A favorable clini-cal response was obtained in this group of patients. |
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| ISSN: | 0375-1112 1995-7068 |