Solitary Subcutaneous Nodular Lymphoid Lesions in Dogs: Histopathologic and Immunophenotypic Comparison of B-Cell Pseudolymphoma and Subcutaneous Panniculitis-like T-Cell Lymphoma
This report describes two cases of solitary subcutaneous nodular lymphoid lesions in dogs. Case 1 involved a 6-year-old male Maltese and Case 2 a 5-year-old female Yorkshire Terrier. Both presented with firm, non-ulcerated dorsal subcutaneous nodules and were unresponsive to corticosteroids. Surgica...
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2025-05-01
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| author | Young-Hyun Koo Hyo-Sung Kim Woo-Jin Kim Hye-Ji Oh Byoung-Je Lee Chang-Kyun Im Sun-Hee Do |
| author_facet | Young-Hyun Koo Hyo-Sung Kim Woo-Jin Kim Hye-Ji Oh Byoung-Je Lee Chang-Kyun Im Sun-Hee Do |
| author_sort | Young-Hyun Koo |
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| description | This report describes two cases of solitary subcutaneous nodular lymphoid lesions in dogs. Case 1 involved a 6-year-old male Maltese and Case 2 a 5-year-old female Yorkshire Terrier. Both presented with firm, non-ulcerated dorsal subcutaneous nodules and were unresponsive to corticosteroids. Surgical excision was performed for diagnosis. Histopathology and immunohistochemistry revealed distinct patterns. Case 1 exhibited well-formed lymphoid follicles with CD20<sup>+</sup>/PAX5<sup>+</sup> B cells and strong BCL6 but absent BCL2 expression, consistent with B-cell pseudolymphoma. Case 2 demonstrated diffuse CD3<sup>+</sup> T-cell infiltrates with adipocyte rimming and minimal BCL2/BCL6 expression, diagnostic for SPTCL. Despite their similar clinical presentation, these two lesions were histopathologically and immunophenotypically distinct. These findings underscore the importance of histologic and immunophenotypic correlation in accurately distinguishing benign from malignant subcutaneous lymphoid proliferations in dogs. |
| format | Article |
| id | doaj-art-4cc43e2178d54d0d93cf40326f847b42 |
| institution | Kabale University |
| issn | 2306-7381 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj-art-4cc43e2178d54d0d93cf40326f847b422025-08-20T03:26:53ZengMDPI AGVeterinary Sciences2306-73812025-05-0112653210.3390/vetsci12060532Solitary Subcutaneous Nodular Lymphoid Lesions in Dogs: Histopathologic and Immunophenotypic Comparison of B-Cell Pseudolymphoma and Subcutaneous Panniculitis-like T-Cell LymphomaYoung-Hyun Koo0Hyo-Sung Kim1Woo-Jin Kim2Hye-Ji Oh3Byoung-Je Lee4Chang-Kyun Im5Sun-Hee Do6Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaDeok-Chun Animal Hospital, 119, Mandeok-daero, Buk-gu, Busan 46554, Republic of KoreaA-ji Animal Hospital, 289, Dokseodang-ro, Seongdong-gu, Seoul 04725, Republic of KoreaDepartment of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaThis report describes two cases of solitary subcutaneous nodular lymphoid lesions in dogs. Case 1 involved a 6-year-old male Maltese and Case 2 a 5-year-old female Yorkshire Terrier. Both presented with firm, non-ulcerated dorsal subcutaneous nodules and were unresponsive to corticosteroids. Surgical excision was performed for diagnosis. Histopathology and immunohistochemistry revealed distinct patterns. Case 1 exhibited well-formed lymphoid follicles with CD20<sup>+</sup>/PAX5<sup>+</sup> B cells and strong BCL6 but absent BCL2 expression, consistent with B-cell pseudolymphoma. Case 2 demonstrated diffuse CD3<sup>+</sup> T-cell infiltrates with adipocyte rimming and minimal BCL2/BCL6 expression, diagnostic for SPTCL. Despite their similar clinical presentation, these two lesions were histopathologically and immunophenotypically distinct. These findings underscore the importance of histologic and immunophenotypic correlation in accurately distinguishing benign from malignant subcutaneous lymphoid proliferations in dogs.https://www.mdpi.com/2306-7381/12/6/532cutaneous pseudolymphomasubcutaneous panniculitis-like T-cell lymphomaB-cell hyperplasiaT-cell lymphomalymhocyte-rich panniculitis |
| spellingShingle | Young-Hyun Koo Hyo-Sung Kim Woo-Jin Kim Hye-Ji Oh Byoung-Je Lee Chang-Kyun Im Sun-Hee Do Solitary Subcutaneous Nodular Lymphoid Lesions in Dogs: Histopathologic and Immunophenotypic Comparison of B-Cell Pseudolymphoma and Subcutaneous Panniculitis-like T-Cell Lymphoma Veterinary Sciences cutaneous pseudolymphoma subcutaneous panniculitis-like T-cell lymphoma B-cell hyperplasia T-cell lymphoma lymhocyte-rich panniculitis |
| title | Solitary Subcutaneous Nodular Lymphoid Lesions in Dogs: Histopathologic and Immunophenotypic Comparison of B-Cell Pseudolymphoma and Subcutaneous Panniculitis-like T-Cell Lymphoma |
| title_full | Solitary Subcutaneous Nodular Lymphoid Lesions in Dogs: Histopathologic and Immunophenotypic Comparison of B-Cell Pseudolymphoma and Subcutaneous Panniculitis-like T-Cell Lymphoma |
| title_fullStr | Solitary Subcutaneous Nodular Lymphoid Lesions in Dogs: Histopathologic and Immunophenotypic Comparison of B-Cell Pseudolymphoma and Subcutaneous Panniculitis-like T-Cell Lymphoma |
| title_full_unstemmed | Solitary Subcutaneous Nodular Lymphoid Lesions in Dogs: Histopathologic and Immunophenotypic Comparison of B-Cell Pseudolymphoma and Subcutaneous Panniculitis-like T-Cell Lymphoma |
| title_short | Solitary Subcutaneous Nodular Lymphoid Lesions in Dogs: Histopathologic and Immunophenotypic Comparison of B-Cell Pseudolymphoma and Subcutaneous Panniculitis-like T-Cell Lymphoma |
| title_sort | solitary subcutaneous nodular lymphoid lesions in dogs histopathologic and immunophenotypic comparison of b cell pseudolymphoma and subcutaneous panniculitis like t cell lymphoma |
| topic | cutaneous pseudolymphoma subcutaneous panniculitis-like T-cell lymphoma B-cell hyperplasia T-cell lymphoma lymhocyte-rich panniculitis |
| url | https://www.mdpi.com/2306-7381/12/6/532 |
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