Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

Etoposide, an anticancer drug that inhibits topoisomerase II, is commonly used in combination chemotherapy. However, the impact of O‐GlcNAcylation regulation on etoposide's anticancer effects has rarely been investigated. This study evaluated the effect of etoposide on cellular O‐GlcNAcylation...

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Bibliographic Details
Main Authors: Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:FEBS Open Bio
Subjects:
anticancer
apoptosis
chemotherapy
etoposide
O‐GlcNAc transferase inhibitor
p53
Online Access:https://doi.org/10.1002/2211-5463.70028
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