A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives
Some[Arylidenamino]-1,3,4-thiadiazino[6,5b] indoles have been synthesized starting from indole-2,3-dione, thiosemicarbazide and aromatic aldehydes with activating and deactivating groups. Inclusion complexes of these compounds have been prepared with β-cyclodextrin so as increase the solubility and...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/156346 |
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| author | Sunakar Panda Jagat Krushna Tripathy |
| author_facet | Sunakar Panda Jagat Krushna Tripathy |
| author_sort | Sunakar Panda |
| collection | DOAJ |
| description | Some[Arylidenamino]-1,3,4-thiadiazino[6,5b] indoles have been synthesized starting from indole-2,3-dione, thiosemicarbazide and aromatic aldehydes with activating and deactivating groups. Inclusion complexes of these compounds have been prepared with β-cyclodextrin so as increase the solubility and bioaccessibility. Thermodynamic properties like change in free energy, change in enthalpy, change in entropy and stability constant of the inclusion complexes have been determined to know whether the inclusion complex formation is thermodynamically allowed or not. The compounds and their inclusion complexes are also screened againt S.aureus and E.coli.to know the antibacterial activity change after inclusion complex formation The antioxidant activities are also studied. |
| format | Article |
| id | doaj-art-4cc030a03da6430e8f4cb81f9624ea9b |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | E-Journal of Chemistry |
| spelling | doaj-art-4cc030a03da6430e8f4cb81f9624ea9b2025-08-20T03:34:19ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01931213122210.1155/2012/156346A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole DerivativesSunakar Panda0Jagat Krushna Tripathy1P.G. Department of Chemistry, Berhampur University, Bhanja Bihar, Odisha, IndiaP.G. Department of Chemistry, Berhampur University, Bhanja Bihar, Odisha, IndiaSome[Arylidenamino]-1,3,4-thiadiazino[6,5b] indoles have been synthesized starting from indole-2,3-dione, thiosemicarbazide and aromatic aldehydes with activating and deactivating groups. Inclusion complexes of these compounds have been prepared with β-cyclodextrin so as increase the solubility and bioaccessibility. Thermodynamic properties like change in free energy, change in enthalpy, change in entropy and stability constant of the inclusion complexes have been determined to know whether the inclusion complex formation is thermodynamically allowed or not. The compounds and their inclusion complexes are also screened againt S.aureus and E.coli.to know the antibacterial activity change after inclusion complex formation The antioxidant activities are also studied.http://dx.doi.org/10.1155/2012/156346 |
| spellingShingle | Sunakar Panda Jagat Krushna Tripathy A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives E-Journal of Chemistry |
| title | A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives |
| title_full | A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives |
| title_fullStr | A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives |
| title_full_unstemmed | A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives |
| title_short | A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives |
| title_sort | comparative study of inclusion complexes of orthosubstituted arylidenamino 1 3 4 thiadiazino 6 5b indole derivatives |
| url | http://dx.doi.org/10.1155/2012/156346 |
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