Tertiary lymphoid structures correlate with the therapeutic efficacy and prognosis of resectable esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy plus immunotherapy

Tertiary lymphoid structures correlate with the therapeutic efficacy and prognosis of resectable esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy plus immunotherapy

BackgroundTertiary lymphoid structures (TLSs) are linked to prognosis in esophageal squamous cell carcinoma (ESCC), but whether the distribution, abundance, and maturity of TLSs affect therapeutic efficacy and prognosis in ESCC treated with neoadjuvant chemoradiotherapy plus immunotherapy (NRCI) rem...

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Bibliographic Details
Main Authors: Ke Zhai, Ru Xie, Kun Ru, Miaoqing Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
tertiary lymphoid structures
esophageal squamous cell carcinoma
neoadjuvant therapy
immunotherapy
chemoradiotherapy
multiplex immunofluorescence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616247/full
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