Ultrasound viscoelastic imaging in the noninvasive quantitative assessment of chronic kidney disease
Background This study aims to evaluate the clinical application value of ultrasound viscoelastic imaging in noninvasive quantitative assessment of chronic kidney disease (CKD).Methods A total of 332 patients with CKD and 190 healthy adults as a control group were prospectively enrolled. Before kidne...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2407882 |
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| author | Han Yuan Qun Huang Jing Wen Yong Gao |
| author_facet | Han Yuan Qun Huang Jing Wen Yong Gao |
| author_sort | Han Yuan |
| collection | DOAJ |
| description | Background This study aims to evaluate the clinical application value of ultrasound viscoelastic imaging in noninvasive quantitative assessment of chronic kidney disease (CKD).Methods A total of 332 patients with CKD and 190 healthy adults as a control group were prospectively enrolled. Before kidney biopsy, ultrasound viscoelastic imaging was performed to measure the mean stiffness value (Emean), mean viscosity coefficient (Vmean), and mean dispersion coefficient (Dmean) of the renal. CKD patients were divided into three groups based on estimated glomerular filtration rate. The differences in clinic, pathology, ultrasound image parameters between the control and patient groups, or among different CKD groups were compared. The correlation between viscoelastic parameters and pathology were analyzed.Results Emean, Vmean, and Dmean in the control group were less than the CKD group (p < 0.05). In the identification of CKD from control groups, the area under curve of Vmean, Dmean, Emean, and combining the three parameters is 0.90, 0.79, 0.69, 0.91, respectively. Dmean and Vmean were increased with the decline of renal function (p < 0.05). Vmean and Dmean were positively correlated with white blood cell, urea, serum creatinine, and uric acid (p < 0.05). Vmean is positively correlated with interstitial fibrosis and inflammatory cell infiltration grades (p < 0.001).Conclusions Ultrasound viscoelastic imaging has advantages in noninvasive quantitative identification and evaluating renal function of CKD. Emean > 6.61 kPa, Vmean > 1.86 Pa·s, or Dmean > 7.51 m/s/kHz may suggest renal dysfunction. Combining Vmean, Dmean, and Emean can improve the efficiency of identifying CKD. |
| format | Article |
| id | doaj-art-4cbc6c240eb84363b9ccf54ed50b7d78 |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-4cbc6c240eb84363b9ccf54ed50b7d782025-08-20T03:05:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2407882Ultrasound viscoelastic imaging in the noninvasive quantitative assessment of chronic kidney diseaseHan Yuan0Qun Huang1Jing Wen2Yong Gao3Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Guangxi, ChinaDepartment of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Guangxi, ChinaDepartment of Hematology and Rheumatology, First Affiliated Hospital of Guangxi Medical University, Guangxi, ChinaDepartment of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Guangxi, ChinaBackground This study aims to evaluate the clinical application value of ultrasound viscoelastic imaging in noninvasive quantitative assessment of chronic kidney disease (CKD).Methods A total of 332 patients with CKD and 190 healthy adults as a control group were prospectively enrolled. Before kidney biopsy, ultrasound viscoelastic imaging was performed to measure the mean stiffness value (Emean), mean viscosity coefficient (Vmean), and mean dispersion coefficient (Dmean) of the renal. CKD patients were divided into three groups based on estimated glomerular filtration rate. The differences in clinic, pathology, ultrasound image parameters between the control and patient groups, or among different CKD groups were compared. The correlation between viscoelastic parameters and pathology were analyzed.Results Emean, Vmean, and Dmean in the control group were less than the CKD group (p < 0.05). In the identification of CKD from control groups, the area under curve of Vmean, Dmean, Emean, and combining the three parameters is 0.90, 0.79, 0.69, 0.91, respectively. Dmean and Vmean were increased with the decline of renal function (p < 0.05). Vmean and Dmean were positively correlated with white blood cell, urea, serum creatinine, and uric acid (p < 0.05). Vmean is positively correlated with interstitial fibrosis and inflammatory cell infiltration grades (p < 0.001).Conclusions Ultrasound viscoelastic imaging has advantages in noninvasive quantitative identification and evaluating renal function of CKD. Emean > 6.61 kPa, Vmean > 1.86 Pa·s, or Dmean > 7.51 m/s/kHz may suggest renal dysfunction. Combining Vmean, Dmean, and Emean can improve the efficiency of identifying CKD.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2407882Ultrasound viscoelastic imagingchronic kidney diseaserenal functioninterstitial fibrosisinflammation |
| spellingShingle | Han Yuan Qun Huang Jing Wen Yong Gao Ultrasound viscoelastic imaging in the noninvasive quantitative assessment of chronic kidney disease Renal Failure Ultrasound viscoelastic imaging chronic kidney disease renal function interstitial fibrosis inflammation |
| title | Ultrasound viscoelastic imaging in the noninvasive quantitative assessment of chronic kidney disease |
| title_full | Ultrasound viscoelastic imaging in the noninvasive quantitative assessment of chronic kidney disease |
| title_fullStr | Ultrasound viscoelastic imaging in the noninvasive quantitative assessment of chronic kidney disease |
| title_full_unstemmed | Ultrasound viscoelastic imaging in the noninvasive quantitative assessment of chronic kidney disease |
| title_short | Ultrasound viscoelastic imaging in the noninvasive quantitative assessment of chronic kidney disease |
| title_sort | ultrasound viscoelastic imaging in the noninvasive quantitative assessment of chronic kidney disease |
| topic | Ultrasound viscoelastic imaging chronic kidney disease renal function interstitial fibrosis inflammation |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2407882 |
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