Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients
Background. Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers. lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown. Materials and...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/2645904 |
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| author | Dongxue Zhang Xin Liu Bojun Wei Guoliang Qiao Tao Jiang Zhenwen Chen |
| author_facet | Dongxue Zhang Xin Liu Bojun Wei Guoliang Qiao Tao Jiang Zhenwen Chen |
| author_sort | Dongxue Zhang |
| collection | DOAJ |
| description | Background. Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers. lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown. Materials and Methods. We investigated the expression profile of plasma GAS8-AS1 in 97 patients with PTC and 39 patients with nodular goiter by quantitative real-time polymerase chain reaction. Results. GAS8-AS1 expression in plasma was downregulated in patients with PTC in comparison with those in nodular goiters (P<0.001). A low level of plasma GAS8-AS1 expression was correlated with lymph node metastasis (LNM) (P<0.001). Multivariate analysis showed that a reduced GAS8-AS1 level in plasma was associated with LNM (P<0.05). The area under the receiver operating characteristic curve for GAS8-AS1 was 0.746 in LNM prediction (P<0.001). Conclusion. The present study indicates that circulating GAS8-AS1 is a potential biomarker for PTC diagnosis and LNM prediction. |
| format | Article |
| id | doaj-art-4cbba0ea0c84485aa263f641b237023d |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-4cbba0ea0c84485aa263f641b237023d2025-02-03T05:46:56ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/26459042645904Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese PatientsDongxue Zhang0Xin Liu1Bojun Wei2Guoliang Qiao3Tao Jiang4Zhenwen Chen5Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Medical Genetics and Developmental Biology, Capital Medical University, Beijing 100069, ChinaDepartment of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 10038, ChinaDepartment of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Medical Genetics and Developmental Biology, Capital Medical University, Beijing 100069, ChinaBackground. Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers. lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown. Materials and Methods. We investigated the expression profile of plasma GAS8-AS1 in 97 patients with PTC and 39 patients with nodular goiter by quantitative real-time polymerase chain reaction. Results. GAS8-AS1 expression in plasma was downregulated in patients with PTC in comparison with those in nodular goiters (P<0.001). A low level of plasma GAS8-AS1 expression was correlated with lymph node metastasis (LNM) (P<0.001). Multivariate analysis showed that a reduced GAS8-AS1 level in plasma was associated with LNM (P<0.05). The area under the receiver operating characteristic curve for GAS8-AS1 was 0.746 in LNM prediction (P<0.001). Conclusion. The present study indicates that circulating GAS8-AS1 is a potential biomarker for PTC diagnosis and LNM prediction.http://dx.doi.org/10.1155/2017/2645904 |
| spellingShingle | Dongxue Zhang Xin Liu Bojun Wei Guoliang Qiao Tao Jiang Zhenwen Chen Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients International Journal of Endocrinology |
| title | Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients |
| title_full | Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients |
| title_fullStr | Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients |
| title_full_unstemmed | Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients |
| title_short | Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients |
| title_sort | plasma lncrna gas8 as1 as a potential biomarker of papillary thyroid carcinoma in chinese patients |
| url | http://dx.doi.org/10.1155/2017/2645904 |
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