Isolated Synchronous Splenic Metastasis from Endometrial Carcinoma: Case Report
Endometrial carcinoma is the most prevalent malignancy of the female reproductive system. However, splenic metastasis remains an infrequent occurrence due to the spleen's distinct anatomical and microenvironmental characteristics. This case report described a 66-year-old female patient diagnose...
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Duzce University
2025-08-01
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| Series: | Düzce Tıp Fakültesi Dergisi |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/4549301 |
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| author | Atike Pinar Erdoğan Hanife Seda Mavili Mustafa Şahbazlar Gonca Akdere Ateş Mehmet Gürdal Savsar Nagihan Kolkıran |
| author_facet | Atike Pinar Erdoğan Hanife Seda Mavili Mustafa Şahbazlar Gonca Akdere Ateş Mehmet Gürdal Savsar Nagihan Kolkıran |
| author_sort | Atike Pinar Erdoğan |
| collection | DOAJ |
| description | Endometrial carcinoma is the most prevalent malignancy of the female reproductive system. However, splenic metastasis remains an infrequent occurrence due to the spleen's distinct anatomical and microenvironmental characteristics. This case report described a 66-year-old female patient diagnosed with endometrial carcinoma, who underwent total hysterectomy, bilateral salpingo-oophorectomy, pelvic peritonectomy, omentectomy, and splenectomy following the intraoperative detection of splenic metastasis. The histopathological evaluation confirmed high-grade serous carcinoma with a Ki-67 proliferation index of 90%, as well as metastatic involvement of the ovaries, peritoneum, and spleen. The patient subsequently received adjuvant carboplatin-paclitaxel chemotherapy, radiotherapy, and multiple-step systemic therapy due to disease progression. No significant adverse effects were observed in multi-step chemotherapy. The present case demonstrates the diagnostic challenges and treatment strategies encountered in a rare occurrence of endometrial carcinoma with splenic metastasis. |
| format | Article |
| id | doaj-art-4cb8ee03c8ff46088b382f1a4d8d1b8e |
| institution | Kabale University |
| issn | 1307-671X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Duzce University |
| record_format | Article |
| series | Düzce Tıp Fakültesi Dergisi |
| spelling | doaj-art-4cb8ee03c8ff46088b382f1a4d8d1b8e2025-08-25T14:57:47ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2025-08-0127222722910.18678/dtfd.162628897Isolated Synchronous Splenic Metastasis from Endometrial Carcinoma: Case ReportAtike Pinar Erdoğan0https://orcid.org/0000-0003-4859-7574Hanife Seda Mavili1https://orcid.org/0000-0003-3741-8489Mustafa Şahbazlar2https://orcid.org/0000-0003-1857-593XGonca Akdere Ateş3https://orcid.org/0000-0003-0373-7561Mehmet Gürdal Savsar4https://orcid.org/0000-0002-3406-9888Nagihan Kolkıran5https://orcid.org/0000-0001-9344-7212CELAL BAYAR UNIVERSITY, FACULTY OF MEDICINEMANISA CELAL BAYAR UNIVERSITY, SCHOOL OF MEDICINEMANISA CELAL BAYAR UNIVERSITY, SCHOOL OF MEDICINEMANISA CELAL BAYAR UNIVERSITY, SCHOOL OF MEDICINEMANISA CELAL BAYAR UNIVERSITY, SCHOOL OF MEDICINEMANISA CELAL BAYAR UNIVERSITY, SCHOOL OF MEDICINEEndometrial carcinoma is the most prevalent malignancy of the female reproductive system. However, splenic metastasis remains an infrequent occurrence due to the spleen's distinct anatomical and microenvironmental characteristics. This case report described a 66-year-old female patient diagnosed with endometrial carcinoma, who underwent total hysterectomy, bilateral salpingo-oophorectomy, pelvic peritonectomy, omentectomy, and splenectomy following the intraoperative detection of splenic metastasis. The histopathological evaluation confirmed high-grade serous carcinoma with a Ki-67 proliferation index of 90%, as well as metastatic involvement of the ovaries, peritoneum, and spleen. The patient subsequently received adjuvant carboplatin-paclitaxel chemotherapy, radiotherapy, and multiple-step systemic therapy due to disease progression. No significant adverse effects were observed in multi-step chemotherapy. The present case demonstrates the diagnostic challenges and treatment strategies encountered in a rare occurrence of endometrial carcinoma with splenic metastasis.https://dergipark.org.tr/en/download/article-file/4549301endometrial carcinomametastasisspleenendometrial karsinommetastazdalak |
| spellingShingle | Atike Pinar Erdoğan Hanife Seda Mavili Mustafa Şahbazlar Gonca Akdere Ateş Mehmet Gürdal Savsar Nagihan Kolkıran Isolated Synchronous Splenic Metastasis from Endometrial Carcinoma: Case Report Düzce Tıp Fakültesi Dergisi endometrial carcinoma metastasis spleen endometrial karsinom metastaz dalak |
| title | Isolated Synchronous Splenic Metastasis from Endometrial Carcinoma: Case Report |
| title_full | Isolated Synchronous Splenic Metastasis from Endometrial Carcinoma: Case Report |
| title_fullStr | Isolated Synchronous Splenic Metastasis from Endometrial Carcinoma: Case Report |
| title_full_unstemmed | Isolated Synchronous Splenic Metastasis from Endometrial Carcinoma: Case Report |
| title_short | Isolated Synchronous Splenic Metastasis from Endometrial Carcinoma: Case Report |
| title_sort | isolated synchronous splenic metastasis from endometrial carcinoma case report |
| topic | endometrial carcinoma metastasis spleen endometrial karsinom metastaz dalak |
| url | https://dergipark.org.tr/en/download/article-file/4549301 |
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