Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses

Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses

Abstract Intensive efforts have been made to identify features that could serve as biomarkers of aging. Yet, drug-based interventions aimed at lessening the detrimental effects of getting older are lacking. This is largely attributable to tissue-specificity, sex-related differences, and to the diffi...

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Main Authors: Maria Chiara Barbera, Luca Guarrera, Andrea David Re Cecconi, Giada Andrea Cassanmagnago, Arianna Vallerga, Martina Lunardi, Francesca Checchi, Laura Di Rito, Margherita Romeo, Sarah Natalia Mapelli, Benedikt Schoser, Edward V. Generozov, Molecular Genetics Group, Rick Jansen, Eco J. C. de Geus, Brenda Penninx, Jenny van Dongen, Ilaria Craparotta, Rosanna Piccirillo, Ildus I. Ahmetov, Marco Bolis
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56918-3
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