Identification of common mutations and their frequency in METTL5, METTL7A, and METTL7B genes in gastrointestinal cancers based on in silico data
Background and Aim: Identifying key genes involved in the development of gastrointestinal cancers is crucial for understanding the molecular mechanisms underlying these diseases and for developing effective therapeutic and diagnostic strategies. Members of the METTL gene family are known to particip...
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Kashan University of Medical Sciences
2024-08-01
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| Series: | مجله علوم پزشکی فیض (پیوسته) |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-5115-en.pdf |
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| author | Soraya Heydari Maryam Peymani Mehrdad Hashemi Kamran Ghaedi Maliheh Entezari |
| author_facet | Soraya Heydari Maryam Peymani Mehrdad Hashemi Kamran Ghaedi Maliheh Entezari |
| author_sort | Soraya Heydari |
| collection | DOAJ |
| description | Background and Aim: Identifying key genes involved in the development of gastrointestinal cancers is crucial for understanding the molecular mechanisms underlying these diseases and for developing effective therapeutic and diagnostic strategies. Members of the METTL gene family are known to participate in various biological functions and play significant roles in tumorigenesis. This study aims to identify common mutations and their frequencies in three selected genes from this family: METTL5, METTL7A, and METTL7B, in the context of gastrointestinal cancers.
Methods: We utilized DNA sequencing data available for each sample in the TCGA database to identify common mutations and their frequencies in the candidate genes. The MAF data for relevant cancers were downloaded, and the Maftools package was employed to evaluate the frequency and types of mutations across all samples.
Results: Mutations in the METTL5, METTL7A, and METTL7B genes were observed in colorectal and stomach cancers, with additional reports of mutations in esophageal, liver, and pancreatic cancers. The frequency of SNP mutations and missense mutations in these genes was found to be higher than reported in previous studies.
Conclusion: SNP mutations and missense mutations were the most prevalent alterations identified in the METTL5, METTL7A, and METTL7B genes compared to other reports. While in silico screening provides a valuable initial step in identifying mutated genes with potential causal roles in cancer, further experimental validation is necessary. |
| format | Article |
| id | doaj-art-4cace27dd4154ebb84e0571655b88c8f |
| institution | DOAJ |
| issn | 3060-5806 3060-5814 |
| language | fas |
| publishDate | 2024-08-01 |
| publisher | Kashan University of Medical Sciences |
| record_format | Article |
| series | مجله علوم پزشکی فیض (پیوسته) |
| spelling | doaj-art-4cace27dd4154ebb84e0571655b88c8f2025-08-20T02:51:20ZfasKashan University of Medical Sciencesمجله علوم پزشکی فیض (پیوسته)3060-58063060-58142024-08-01283307316Identification of common mutations and their frequency in METTL5, METTL7A, and METTL7B genes in gastrointestinal cancers based on in silico dataSoraya Heydari0Maryam Peymani1Mehrdad Hashemi2Kamran Ghaedi3Maliheh Entezari4 Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Department of Genetics, Faculty of Advanced Sciences and Technologies, Tehran Medical Branch, Islamic Azad University, Tehran, Iran Department of Cell and Molecular Biology, Department of Biology, Faculty of Science, Isfahan University, Isfahan, Iran Department of Genetics, Faculty of Advanced Sciences and Technologies, Tehran Medical Branch, Islamic Azad University, Tehran, Iran Background and Aim: Identifying key genes involved in the development of gastrointestinal cancers is crucial for understanding the molecular mechanisms underlying these diseases and for developing effective therapeutic and diagnostic strategies. Members of the METTL gene family are known to participate in various biological functions and play significant roles in tumorigenesis. This study aims to identify common mutations and their frequencies in three selected genes from this family: METTL5, METTL7A, and METTL7B, in the context of gastrointestinal cancers. Methods: We utilized DNA sequencing data available for each sample in the TCGA database to identify common mutations and their frequencies in the candidate genes. The MAF data for relevant cancers were downloaded, and the Maftools package was employed to evaluate the frequency and types of mutations across all samples. Results: Mutations in the METTL5, METTL7A, and METTL7B genes were observed in colorectal and stomach cancers, with additional reports of mutations in esophageal, liver, and pancreatic cancers. The frequency of SNP mutations and missense mutations in these genes was found to be higher than reported in previous studies. Conclusion: SNP mutations and missense mutations were the most prevalent alterations identified in the METTL5, METTL7A, and METTL7B genes compared to other reports. While in silico screening provides a valuable initial step in identifying mutated genes with potential causal roles in cancer, further experimental validation is necessary.http://feyz.kaums.ac.ir/article-1-5115-en.pdfgastrointestinal cancersmettl genesgene mutations |
| spellingShingle | Soraya Heydari Maryam Peymani Mehrdad Hashemi Kamran Ghaedi Maliheh Entezari Identification of common mutations and their frequency in METTL5, METTL7A, and METTL7B genes in gastrointestinal cancers based on in silico data مجله علوم پزشکی فیض (پیوسته) gastrointestinal cancers mettl genes gene mutations |
| title | Identification of common mutations and their frequency in METTL5, METTL7A, and METTL7B genes in gastrointestinal cancers based on in silico data |
| title_full | Identification of common mutations and their frequency in METTL5, METTL7A, and METTL7B genes in gastrointestinal cancers based on in silico data |
| title_fullStr | Identification of common mutations and their frequency in METTL5, METTL7A, and METTL7B genes in gastrointestinal cancers based on in silico data |
| title_full_unstemmed | Identification of common mutations and their frequency in METTL5, METTL7A, and METTL7B genes in gastrointestinal cancers based on in silico data |
| title_short | Identification of common mutations and their frequency in METTL5, METTL7A, and METTL7B genes in gastrointestinal cancers based on in silico data |
| title_sort | identification of common mutations and their frequency in mettl5 mettl7a and mettl7b genes in gastrointestinal cancers based on in silico data |
| topic | gastrointestinal cancers mettl genes gene mutations |
| url | http://feyz.kaums.ac.ir/article-1-5115-en.pdf |
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