The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study
Abstract To investigate the causal relationship between oral infectious diseases and lacunar stroke (LS) and to identify the role of interleukin-1α (IL-1α), interleukin-6 (IL-6), tumor necrosis factor (TNF), and C-reaction protein (CRP) as potential mediators. The meta-analysis incorporating cross-s...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-99742-x |
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| author | Qifan Zheng Tong Xu Shiyin Luo Jiahui Zhao Yue Ying Nan Liu Aijia Jiang Yaping Pan Dongmei Zhang |
| author_facet | Qifan Zheng Tong Xu Shiyin Luo Jiahui Zhao Yue Ying Nan Liu Aijia Jiang Yaping Pan Dongmei Zhang |
| author_sort | Qifan Zheng |
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| description | Abstract To investigate the causal relationship between oral infectious diseases and lacunar stroke (LS) and to identify the role of interleukin-1α (IL-1α), interleukin-6 (IL-6), tumor necrosis factor (TNF), and C-reaction protein (CRP) as potential mediators. The meta-analysis incorporating cross-sectional studies was carried out. Additionally, two-sample Mendelian randomization (MR) analysis was performed to explore the associations between genetically predicted oral infectious diseases (including dental caries, periodontitis, and pulp and periapical diseases) and lacunar stroke, utilizing summary-level data from genome-wide association studies (GWAS). This was followed by a mediation analysis to explore the role of IL-1α, IL-6, TNF, and CRP. Meta-analysis suggested that individuals with periodontitis have a 5.16 times higher risk of developing LS compared to those without periodontitis (95%CI 3.68–7.24). Genetically predicted pulp and periapical diseases (Odds ratios [OR]: 1.20, 95% CI 1.03–1.41) and periodontitis (OR: 1.24, 95%CI 1.03–1.49) showed a moderate association with LS. However, the mediation analysis yielded negative results. The evidence derived from both the MR study and the meta-analysis suggested a potential association between periodontitis and LS. These findings indicated that periodontitis might play a role in the development of LS. However, given the limitations inherent in our research, further studies are necessary to validate these conclusions. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-4cabf13211f74cc6a341e7ddf6caeda22025-08-20T03:10:14ZengNature PortfolioScientific Reports2045-23222025-05-0115111210.1038/s41598-025-99742-xThe contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization studyQifan Zheng0Tong Xu1Shiyin Luo2Jiahui Zhao3Yue Ying4Nan Liu5Aijia Jiang6Yaping Pan7Dongmei Zhang8Department of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical UniversityDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical UniversityDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical UniversityDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical UniversityDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical UniversityDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical UniversityDepartment of Oral Mucosiology, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical UniversityDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical UniversityDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical UniversityAbstract To investigate the causal relationship between oral infectious diseases and lacunar stroke (LS) and to identify the role of interleukin-1α (IL-1α), interleukin-6 (IL-6), tumor necrosis factor (TNF), and C-reaction protein (CRP) as potential mediators. The meta-analysis incorporating cross-sectional studies was carried out. Additionally, two-sample Mendelian randomization (MR) analysis was performed to explore the associations between genetically predicted oral infectious diseases (including dental caries, periodontitis, and pulp and periapical diseases) and lacunar stroke, utilizing summary-level data from genome-wide association studies (GWAS). This was followed by a mediation analysis to explore the role of IL-1α, IL-6, TNF, and CRP. Meta-analysis suggested that individuals with periodontitis have a 5.16 times higher risk of developing LS compared to those without periodontitis (95%CI 3.68–7.24). Genetically predicted pulp and periapical diseases (Odds ratios [OR]: 1.20, 95% CI 1.03–1.41) and periodontitis (OR: 1.24, 95%CI 1.03–1.49) showed a moderate association with LS. However, the mediation analysis yielded negative results. The evidence derived from both the MR study and the meta-analysis suggested a potential association between periodontitis and LS. These findings indicated that periodontitis might play a role in the development of LS. However, given the limitations inherent in our research, further studies are necessary to validate these conclusions.https://doi.org/10.1038/s41598-025-99742-xOral infectious diseasesPeriodontitisLacunar strokeMendelian randomization analysisMeta-analysis |
| spellingShingle | Qifan Zheng Tong Xu Shiyin Luo Jiahui Zhao Yue Ying Nan Liu Aijia Jiang Yaping Pan Dongmei Zhang The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study Scientific Reports Oral infectious diseases Periodontitis Lacunar stroke Mendelian randomization analysis Meta-analysis |
| title | The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study |
| title_full | The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study |
| title_fullStr | The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study |
| title_full_unstemmed | The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study |
| title_short | The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study |
| title_sort | contribution of oral infectious diseases in lacunar stroke based on meta analysis and mendelian randomization study |
| topic | Oral infectious diseases Periodontitis Lacunar stroke Mendelian randomization analysis Meta-analysis |
| url | https://doi.org/10.1038/s41598-025-99742-x |
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