Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone
Feng Sun, Mingqiu Liu, Yongli Qi, Wenjing Qi, Junyi Li Department of Otolaryngology, Affiliated People’s Hospital of Shandong First Medical University, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Junyi Li, Email joyj968@163.comObjective: To analyze the clinical symptom improvement and...
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Dove Medical Press
2025-07-01
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| author | Sun F Liu M Qi Y Qi W Li J |
| author_facet | Sun F Liu M Qi Y Qi W Li J |
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| description | Feng Sun, Mingqiu Liu, Yongli Qi, Wenjing Qi, Junyi Li Department of Otolaryngology, Affiliated People’s Hospital of Shandong First Medical University, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Junyi Li, Email joyj968@163.comObjective: To analyze the clinical symptom improvement and recurrence rate of chronic suppurative otitis media (CSOM) patients treated with a combination therapy regimen (combination of ofloxacin and dexamethasone).Methods: Based on the treatment regimen, patients were divided into two groups: the control group was treated with dexamethasone, while the treatment group received a combination of ofloxacin and dexamethasone. The clinical symptom improvement, hearing evaluation, pathogen clearance rate, inflammatory marker detection, adverse reactions, recurrence rate and recurrence rate post-treatment were compared between the two groups.Results: There were no significant differences in the baseline clinical data between the two groups (P > 0.05). The overall clinical efficacy of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, the improvements in air conduction (AC) and air-bone gap (ABG) in the treatment group were significantly greater than those in the control group (P < 0.05). The time for the resolution of tympanic membrane congestion and the healing of perforations was shorter in the treatment group compared to the control group (P < 0.05). The pathogen clearance rate in the treatment group was significantly higher than in the control group (P < 0.05). After treatment, levels of inflammatory markers IL-8, TGF-β 1, and PCT in the treatment group were significantly lower than those in the control group (P < 0.05).Conclusion: The combination therapy of ofloxacin and dexamethasone significantly improves the clinical symptoms, reduces the recurrence rate, and lowers the incidence of adverse reactions in chronic suppurative otitis media patients. It shows significant clinical efficacy with improved hearing outcomes, and is worthy of clinical promotion. However, this study still has certain limitations, such as the possibility of introducing selection bias. In the future, prospective clinical trials with multiple centers and large samples can be conducted.Keywords: ofloxacin, dexamethasone, chronic suppurative otitis media, clinical symptoms, recurrence rate, treatment effect |
| format | Article |
| id | doaj-art-4ca98f822cf04436b8ab758e30f991fb |
| institution | Kabale University |
| issn | 1179-1594 |
| language | English |
| publishDate | 2025-07-01 |
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| series | Risk Management and Healthcare Policy |
| spelling | doaj-art-4ca98f822cf04436b8ab758e30f991fb2025-08-20T03:30:49ZengDove Medical PressRisk Management and Healthcare Policy1179-15942025-07-01Volume 18Issue 122752285104476Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and DexamethasoneSun F0Liu MQi YQi WLi J1Department of OtolaryngologyDepartment of OtolaryngologyFeng Sun, Mingqiu Liu, Yongli Qi, Wenjing Qi, Junyi Li Department of Otolaryngology, Affiliated People’s Hospital of Shandong First Medical University, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Junyi Li, Email joyj968@163.comObjective: To analyze the clinical symptom improvement and recurrence rate of chronic suppurative otitis media (CSOM) patients treated with a combination therapy regimen (combination of ofloxacin and dexamethasone).Methods: Based on the treatment regimen, patients were divided into two groups: the control group was treated with dexamethasone, while the treatment group received a combination of ofloxacin and dexamethasone. The clinical symptom improvement, hearing evaluation, pathogen clearance rate, inflammatory marker detection, adverse reactions, recurrence rate and recurrence rate post-treatment were compared between the two groups.Results: There were no significant differences in the baseline clinical data between the two groups (P > 0.05). The overall clinical efficacy of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, the improvements in air conduction (AC) and air-bone gap (ABG) in the treatment group were significantly greater than those in the control group (P < 0.05). The time for the resolution of tympanic membrane congestion and the healing of perforations was shorter in the treatment group compared to the control group (P < 0.05). The pathogen clearance rate in the treatment group was significantly higher than in the control group (P < 0.05). After treatment, levels of inflammatory markers IL-8, TGF-β 1, and PCT in the treatment group were significantly lower than those in the control group (P < 0.05).Conclusion: The combination therapy of ofloxacin and dexamethasone significantly improves the clinical symptoms, reduces the recurrence rate, and lowers the incidence of adverse reactions in chronic suppurative otitis media patients. It shows significant clinical efficacy with improved hearing outcomes, and is worthy of clinical promotion. However, this study still has certain limitations, such as the possibility of introducing selection bias. In the future, prospective clinical trials with multiple centers and large samples can be conducted.Keywords: ofloxacin, dexamethasone, chronic suppurative otitis media, clinical symptoms, recurrence rate, treatment effecthttps://www.dovepress.com/analysis-of-the-clinical-symptom-improvement-and-recurrence-rate-in-ch-peer-reviewed-fulltext-article-RMHPOfloxacinDexamethasoneChronic Suppurative Otitis MediaClinical SymptomsRecurrence RateTreatment Effect |
| spellingShingle | Sun F Liu M Qi Y Qi W Li J Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone Risk Management and Healthcare Policy Ofloxacin Dexamethasone Chronic Suppurative Otitis Media Clinical Symptoms Recurrence Rate Treatment Effect |
| title | Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone |
| title_full | Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone |
| title_fullStr | Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone |
| title_full_unstemmed | Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone |
| title_short | Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone |
| title_sort | analysis of the clinical symptom improvement and recurrence rate in chronic suppurative otitis media patients treated with combination therapy combination of ofloxacin and dexamethasone |
| topic | Ofloxacin Dexamethasone Chronic Suppurative Otitis Media Clinical Symptoms Recurrence Rate Treatment Effect |
| url | https://www.dovepress.com/analysis-of-the-clinical-symptom-improvement-and-recurrence-rate-in-ch-peer-reviewed-fulltext-article-RMHP |
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