The Influence of Neocate in Paediatric Short Bowel Syndrome on PN Weaning

Clinical management of short bowel syndrome remains a multistage process. Although PN is crucial, early introduction of enteral feeding is mandatory. We describe retrospectively 4 patients with an ultrashort bowel who could be weaned off PN on very short terms after introduction of an amino-acid-bas...

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Main Authors: E. De Greef, T. Mahler, A. Janssen, H. Cuypers, G. Veereman-Wauters
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Journal of Nutrition and Metabolism
Online Access:http://dx.doi.org/10.1155/2010/297575
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author E. De Greef
T. Mahler
A. Janssen
H. Cuypers
G. Veereman-Wauters
author_facet E. De Greef
T. Mahler
A. Janssen
H. Cuypers
G. Veereman-Wauters
author_sort E. De Greef
collection DOAJ
description Clinical management of short bowel syndrome remains a multistage process. Although PN is crucial, early introduction of enteral feeding is mandatory. We describe retrospectively 4 patients with an ultrashort bowel who could be weaned off PN on very short terms after introduction of an amino-acid-based formula (Neocate). Patient 1 had congenital short bowel with 50 cm small bowel and 30 cm colon. He had persistent diarrhoea on a semielementary formula. When Neocate was introduced he could be weaned from PN within 6 months. Patient 2 needed multiple surgical interventions because of NEC at D 27. He maintained 40 cm small bowel and an intact colon and remained PN dependent on semielemental formula. After introducing Neocate, PN could be weaned within 3 months. In the next 2 patients, Neocate was introduced as initial enteral feeding after bowel resection following antenatal midgut volvulus. Patient 3 had 20 cm small bowel and an intact colon. PN was weaned after 2 months. Patient 4 had 9 cm small bowel and an intact colon. PN was weaned after 13 months. In all patients Ileocaecal valve (ICV) was preserved. No consensus is reached on the type of formula to use for short bowel syndrome. Compared to recent data in the literature, the weaning period in these 4 patients was significantly shortened on an aminoacid based formula. The reason for this may lie in the antiallergic properties of this formula. We recommend the use of an amino-acid-based formula to induce earlier weaning of PN.
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spelling doaj-art-4ca1756986594a05bea5d6cc028f72652025-02-03T06:44:41ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322010-01-01201010.1155/2010/297575297575The Influence of Neocate in Paediatric Short Bowel Syndrome on PN WeaningE. De Greef0T. Mahler1A. Janssen2H. Cuypers3G. Veereman-Wauters4Queen Paola Children's Hospital ZNA, Antwerp, BelgiumQueen Paola Children's Hospital ZNA, Antwerp, BelgiumQueen Paola Children's Hospital ZNA, Antwerp, BelgiumQueen Paola Children's Hospital ZNA, Antwerp, BelgiumQueen Paola Children's Hospital ZNA, Antwerp, BelgiumClinical management of short bowel syndrome remains a multistage process. Although PN is crucial, early introduction of enteral feeding is mandatory. We describe retrospectively 4 patients with an ultrashort bowel who could be weaned off PN on very short terms after introduction of an amino-acid-based formula (Neocate). Patient 1 had congenital short bowel with 50 cm small bowel and 30 cm colon. He had persistent diarrhoea on a semielementary formula. When Neocate was introduced he could be weaned from PN within 6 months. Patient 2 needed multiple surgical interventions because of NEC at D 27. He maintained 40 cm small bowel and an intact colon and remained PN dependent on semielemental formula. After introducing Neocate, PN could be weaned within 3 months. In the next 2 patients, Neocate was introduced as initial enteral feeding after bowel resection following antenatal midgut volvulus. Patient 3 had 20 cm small bowel and an intact colon. PN was weaned after 2 months. Patient 4 had 9 cm small bowel and an intact colon. PN was weaned after 13 months. In all patients Ileocaecal valve (ICV) was preserved. No consensus is reached on the type of formula to use for short bowel syndrome. Compared to recent data in the literature, the weaning period in these 4 patients was significantly shortened on an aminoacid based formula. The reason for this may lie in the antiallergic properties of this formula. We recommend the use of an amino-acid-based formula to induce earlier weaning of PN.http://dx.doi.org/10.1155/2010/297575
spellingShingle E. De Greef
T. Mahler
A. Janssen
H. Cuypers
G. Veereman-Wauters
The Influence of Neocate in Paediatric Short Bowel Syndrome on PN Weaning
Journal of Nutrition and Metabolism
title The Influence of Neocate in Paediatric Short Bowel Syndrome on PN Weaning
title_full The Influence of Neocate in Paediatric Short Bowel Syndrome on PN Weaning
title_fullStr The Influence of Neocate in Paediatric Short Bowel Syndrome on PN Weaning
title_full_unstemmed The Influence of Neocate in Paediatric Short Bowel Syndrome on PN Weaning
title_short The Influence of Neocate in Paediatric Short Bowel Syndrome on PN Weaning
title_sort influence of neocate in paediatric short bowel syndrome on pn weaning
url http://dx.doi.org/10.1155/2010/297575
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